The study was carried out on 31 diabetic patients of both sexes hospitalised in the Clinical Hospital of Diabetes and Nutritional Diseases "Dr. I. Cantacuzino". They were divided in 2 groups: patients with insulin-dependent diabetes (IDDM) and noninsulin-dependent diabetes (NIDDM) and compared with a group of control non-diabetic subjects. Total mixed saliva was sampled in the morning (07:30-08:00) and in the afternoon (17:30-18:00) without stimulation and tested for amylase activity, proteins and density. The study revealed that the density and the amylase activity have the same diurnal behaviour for the diabetic patients and healthy control subjects either. The only difference was the amplitude of maximal activity (in the morning for density and in the afternoon for the amylase activity). Salivary proteins have a similar diurnal behaviour for both diabetic groups (maximal values in the morning and minimal values in the afternoon) in contrast to healthy control subjects that presented less obvious diurnal changes.

Adolescent↗

PubMedDate not supplied

Diurnal behaviour of some salivary parameters in patients with diabetes mellitus (flow rate, pH, thiocianat, LDH activity)--note II.

The study was performed on 31 diabetic patients of both sexes, divided in 2 groups: group I--17 patients with insulin-dependent diabetes (IDDM) and group II--14 patients with noninsulin-dependent diabetes (NIDDM) and compared with a control group of 16 non-diabetic subjects. Mixed saliva was sampled without stimulation during 2 periods of the day: 07:30-08:00 before breakfast and 17:30-18:00 before dinner. We determined: salivary flow rate, pH with Merck indicator and, after homogenization, the thiocianat with the FeCl3 method and LDH activity (the Norbert method adapted in our laboratory for saliva). Our study showed the same diurnal changes in flow rate and salivary pH in both diabetic and control groups: minimal values in the morning and maximal ones in the afternoon. In non-smoking diabetic patients the salivary thiocianat had maximal values in the morning and minimal ones in the afternoon; similar behaviour, but less obvious was observed in smoking diabetic patients and in the control group regardless of the smoking habit. LDH activity showed unsignificant diurnal variations in the diabetic patients. In the control group we found a significant decrease of LDH activity in the afternoon. The discussion is about the implication of these salivary parameters in the pathology of oral cavity: gingivitis, periodontitis and caries in diabetic patients.

Adolescent↗

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[Nebivolol treatment in essential arterial hypertension].

Nebivolol is a lipophilic beta 1-blocker. It is devoid of intrinsic sympathomimetic or membrane stabilising activity but appears to have nitric oxide-mediated vasodilatory effects. Nebivolol 5 mg once daily is well tolerated in patients with hypertension. Adverse events are infrequent, transient and mild to moderate. Those reported most often include headache, fatigue, paraesthesias and dizziness. Several studies reported no signs of orthostatic hypotension with Nebivolol.

Antihypertensive Agents↗

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[Intestinal tuberculosis--cause of acute surgical abdomen].

Tuberculosis, in its various forms, remains an important cause of morbidity and mortality in developing countries in immunodeficitary patients. The indicatives of epidemiology of tuberculosis show that Romania presents a fresh outbreak of the disease in the last few years. The purpose of this paper is to present from the various forms of extrapulmonary tuberculosis, the intestinal tipe which have a high incidence. The authors describe theirs preliminary experience of intraoperative small and large bowel emergencies resections in a short period (1 year) of three young patients (between 30 and 40 years old) with history of pulmonary tuberculosis. The pathology was complex (bowel obstructions, peritonitis) and so were the surgical operations (resections, devirations). The patients showed short and long term good results.

Adult↗

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[Therapeutic means and methods in recurrent pleurisy].

During a 10-year interval (1981-1991), at the IIIrd Medical Clinic of Iaşi 960 cases with pleural effusion, of which 768 (80%) non-recurrent and 192 (20%) recurrent, were diagnosed. The etiology in the latter cases was malignant (40%) and non-malignant (60%). Proper treatment methods for limiting or suppressing the recurrent pleurisies proved to be imperative. Thoracocenteses cause protein and electrolyte depletion which aggravate the general state and hasten the unfavourable evolution of the etiological affection. This is the reason why besides the general etiopathogenic treatment, a local pathogenic treatment (cytostatic, anti-inflammatory) and especially pleurodesis are compulsory. The intrapleural administration of cortisone is efficient in the case of recurrent autoimmune pleural effusions but is worthless in the malignant ones. In the latter situation, the intrapleural cytostatic treatment should be first attempted and, in case of failure, the development of pleural symphysis by external radiotherapy or injecting talc into the pleural space should be made. In the terminal stage of cardiac insufficiency or liver cirrhosis with recurrent pleural effusion, the pleurosymphysation is not indicated; a sever edematous-ascitic attack may occur or become aggravated by the pleural irritative process due to this method.

Biopsy↗

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[The experience of the 3rd Medical Clinic with lymph node pathology].

In the last 8 years, 511 patients (267 men and 244 women) were investigated. It was found that 44 cases (8.6%) were false adenopathies (various types of tumoral masses) but placed in the nodes areas (localized, generalized or deep). There were 467 cases of true lymphadenopathies, 58 new cases yearly (2.32% of all admitted patients and 6.9% of those with blood diseases). Out of these 467 cases, 330 (70.6%) were malignant neoplastic diseases: malignant lymphomas--206 cases (62.4% of all malignancies), leukemias--99 cases (30%), carcinomatous metastases--25 cases (7.6%). Nonmalignant lymphadenopathies were found in 137 cases (29.4%): specific infections (tuberculosis) and nonspecific ones in 87 cases (63.5%), nonimmune diseases (SLE, PAN, sarcoidosis) in 50 cases. Generalized adenopathies were recorded in 47% of the cases, the involvement of a single node group in 21.8% of the cases, other types of distribution being rare. The general symptoms were absent in 20.5% of the cases, being present in the remainder of 79.5%, especially in the malignant lymphomas, leukemias, nonimmune diseases. The main complications occurring against the background of the etiological affections of lymphadenopathies were: infections (respiratory, urinary, tegumental) in 19.7% of the cases and cardiovascular disturbances (myocardiopathies, rythm and conduction disturbances) in 9.6% of the cases.

Adolescent↗

PubMedDate not supplied

[Regulation of bronchial motility].

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Asthma↗

PubMedDate not supplied

Effects of a seven-day hypokinesia on the digestive tract of nonpregnant and pregnant rats.

Hypokinesia (HK) produced by a 7-day contention of pregnant rats in small cages is followed by a discrete decrease of PAS reaction for glycoproteins in the submandibular and sublingual glands, in the mucosa of the stomach, duodenum, small intestine and colon, and also by a small but evident increase of that for leucineaminopeptidase and acid phosphatase in the duodenum and in the intestine. The moderation of these reactions may be explained by the small interval of contention, and not by pregnancy, because the changes are similar in male rats after the same interval. After a longer interval, these reactions change in the same manner but they are more evident, as results from our previous studies. They are not connected with a corticosterone hypersecretion (the principal glucocorticoid in rat) because adrenalectomy does not influence them as results from our previous research. HK increases the 4 and 5 isoenzymes of lactic dehydrogenase (LDH) in the stomach. In the small intestine appeared only the LDH 4 and 5 isoenzymes, HK increases LDH5 isoenzyme. Adrenalectomy increases all LDH isoenzymes of gastric mucosa, and in the small intestine all five fractions appeared, but with a slight activity of LDH 1 and 2. This relation between adrenal hormones and these isoenzymes must be further studied, especially after HK. After a 7-day HK, nonpregnant female rats present an augmented total gastric acid output (TAO), as previously found by us in males. After adrenalectomy this acid hypersecretion disappeared. Even smaller values for TAO were found. Pregnancy considerably increased TAO which may be due, as we have already found, to a blood pH decrease. After HK this hypersecretion decreased remaining nevertheless great. Progeni born of rats submitted to HK have, after 30 days of life, an augmented TAO. Parts of this research were carried out in order to reproduce by HK, at ground level, the 5-day orbital flight conditions of the soviet Cosmos 1514 biosatellite containing pregnant rats in which we studied some identical parameters.

Acid-Base Equilibrium↗

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