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Biomedical subjects

S Inoue

Publications and source records attributed to S Inoue.

At least 1,513 records · Page 84Linked to original sources
PubMed1982

[Combined administration of futraful and esquinone for the treatment of advanced ovarian cancer].

Thirty-seven patients with advanced ovarian cancer were treated with futraful (FT-207) and esquinone (CQ). These patients had infiltrated tumors to the pelvic and peritoneal cavity and also distant metastasis, so they were not operated perfectly. There were evaluable 12 patients out of 37. FT-207 + CQ is an effective drug combination against advanced ovarian cancer with an overall response rete of 40.9%, a complete response rate of 4.5% (1/22), partial response rate of 36.4% (8/22), no change rate of 27.3% (6/22) and progressive rate of 31.8% (7/22). Patients with adenocarcinoma showed a response rate of 66.7% (8/12). According to the stage, the patients in stage III showed response rate of 50.0% (6/12), in stage IV showed a response rate of 37.5% (3/8). The total dose of FT-207 used in the study was 38.3g in the progressive disease group and 177.6 in the good response group. The group of long term administration of FT-207 and CQ included many patients with good response.

Adenocarcinoma↗
PubMed1982

Effect of hypophysectomy and starvation on the fine structure of vitellogenic oocytes in the newt, Triturus pyrrhogaster (Laur).

Hypophysectomy and starvation in Triturus pyrrhogaster result in a similar ultrastructural pattern of follicular atresia. The first detectable change in the oocytes is decrease in the size and number of microvilli. Subsequently the yolk precursor bodies (YPB) disappear from the micropinocytotic vesicles and the mitochondria degenerate. Finally the yolk platelets undergo decomposition. The smaller yolk platelets disintegrate by granulation, vacuolation and lobule formation. The larger platelets, after losing their superficial layer and the inner crystalline lattice, are surrounded by a laminated membrane complex. The pattern of yolk breakdown is comparable to that during development. A rather delayed effect is observed on the nucleolus of the oocytes. Pigment granules seem to play an important role in the proteolysis of the yolk.

Animals↗
PubMed1982

Normal sister chromatid exchange frequency in long-term survivors with acute leukemia.

We hypothesized that the sister chromatid exchanges assay in acute leukemia long-term survivors may detect: (a) long-term effects of combined chemo- and radiotherapy; and possibly (b) those individuals with inherently deficient DNA repair. Accordingly, we determined the sister chromatid exchanges frequency in 26 blood specimens from 24 acute leukemia long-term survivors (patients) and 14 blood specimens from 13 control subjects (controls). The patients consisted of 23 children with acute lymphocytic and one child with acute myelocytic leukemia. The median length of chemotherapy was 5 years. Eighteen of the 24 patients also received prophylactic fractional central nervous system irradiation for the first 3 years of treatment, and one patient received therapeutic irradiation to the central nervous system. The median off-therapy period at the time of study was 2.5 years with a range of 0 to 7.5 years. The controls consisted of the parents of the patients and laboratory personnel. A mean exchange score per cell was established for each specimen (25 to 30 cells/specimen were scored), and it ranged from 3.0 to 9.7 in the patients and from 3.0 to 11.5 in the controls. A mean +/- S.D. calculated from those means was 6.0 +/- 1.8 for the patients and 6.9 +/- 2.8 for the controls. They were not significantly different. We conclude that chemo- and radiotherapy produced no persistent DNA alterations detectable by this method.

Child↗
PubMed1982

Renal tubular dysfunction as a complication of gold therapy in patients with rheumatoid arthritis.

Forty-five patients with uncomplicated rheumatoid arthritis and 45 control individuals were subjected to immunochemical investigation of the urinary excretion of renal tubular basement membrane antigen (TBM), renal tubular epithelial antigen (RTE), and beta-2-microglobulin. Tubular proteinuria occurred significantly more frequently in patients treated with gold salts than in those not treated (P less than 0.05). Large amounts of RTE and TBM were detected only in the urine of patients who received gold salt therapy. However, the amounts of these proteins in urine did no correlate with the total dose of gold. These results indicate that renal tubular damage frequently occurs in patients with rheumatoid arthritis who are treated with gold salts; the tests outlined are useful in detecting renal tubular disorders developing during gold salt therapy and have certain advantages over routine urinalysis.

Adult↗
PubMed1982

Clinicopathologic studies in tympanosclerosis.

Light-and electron-microscopic studies of the tissue from middle ears diagnosed as having tympanosclerosis, adhesive otitis media, postinflammatory ossicular fixation, and chronic otitis media revealed more or less similar findings of inflammatory response and healing. The histopathologic findings of "whitish sclerotic masses," especially around the ossicular chains, were due to fibrosis of submucosal connective tissue with hyalinization and calcification and/or metaplasia of mucosal epithelium. Longstanding and repeated undrained suppurative or nonsuppurative effusions would promote progressively more dense and avascular fibrous adhesions in the tympanum. The extensive fibrous changes in the tympanum would be a consequence of inadequate antibiotic therapy for middle ear inflammation and effusion. A new diagnostic term of tympanomastoidfibrosis is proposed to explain these clinical and histopathologic conditions as a replacement for the terms tympanosclerosis, adhesive otitis media, inflammatory ossicular fixation, and so on.

Adult↗
PubMed1982

The reaction of cartilage and osteophyte formation after the intraarticular injection of papain.

A histological and autoradiographical study on the reaction of chondrocytes and the growing processes of osteophyte after the intraarticular injection of papain was carried out. The degenerating processes--fibrillation, death of chondrocytes and erosion--were observed as early as 1 day after the injection, and acid mucopolysaccharide staining with safranin-O was completely lost throughout the articular cartilage 1 week after the injection. The regenerating or proliferating figures--chondrocytes mitosis, thickening of fibrous tissue--were observed as early as 3 days after the injection and chondrocyte clusters were noted after 1 week of injection. Four weeks after injection, proliferating processes were more obvious than degenerating processes, safranin-O stainability had recovered and the proliferative figures of cartilage and fibrous tissue became more obvious. As blood vessels invaded into the cartilage and thickened fibrous tissue, osteophyte began to form in these tissues. Four types of growing processes of osteophyte were observed. Hypertrophy of articular cartilage was observed, and new hyaline articular cartilage appeared to be formed through metaplasia from fibrous tissue. Including the osteophyte formation, tremendous regenerating or repairing efforts of chondrocytes and fibroblasts were observed. These results appear to indicate that cartilage has some ability to regenerate and to repair itself if it could avoid further damage.

Animals↗
PubMed1982

Parathyroid hormone immunoreactivity in the plasma filtrate of uremic patients.

Plasma filtrate of uremic patients concentrated and fractionated by gel filtration consisted of a large peak with C-terminal immunoreactivity and a small peak with N-terminal immunoreactivity. Further analysis of the first peak with C-terminal immunoreactivity by ion exchange chromatography revealed at least 3 peaks indicating the presence of three peaks with a similar immunological behavior but different charge. The elution profile in a patient under chronic hemofiltration was different in pattern compared with that in 2 patients under conventional hemodialysis.

Chromatography, Gel↗
PubMed1982

[Intracerebral fibrous xanthosarcoma--report of a case].

A 61-year-old and right handed man was admitted to our department on August 11, 1980. The patient had three month history of focal fits, progressive hemiplegia, and motor dominant aphasia. The neuroradiological examination revealed a space taking lesion at the left frontoparietal area, which showed a small tumor stain with early filled draining vein on the left carotid angiogram, and iso-high dense mass with marked contrast enhancement on the CT scan. The EEG findings showed polymorphous delta rhythm in the left frontal and parietal areas. On August 28, total removal of the tumor was performed. The tumor was a intracerebral, fibrous cystic mass without involvement of the pia and dura mater. The removed tumor was measured approximately 6 X 5 X 4 cm in size, and consistence of the tumor was mostly elastic hard and partially soft and hemorrhagic. Histologically, the tumor composed of an admixture of bizarre histiocytes and fibroblasts, multinucleated giant cells, xanthoma cells and siderophages, with fibrous stroma. After surgery, no distinct lesion was demonstrated on the whole body CT scan and garium and technetium scintigram in the abdomen and the lung. The right hemiplegia and aphasia were improved gradually, and the patient discharged on December 20, 1980. We discussed the origin of this tumor, and angiographic and CT scan findings on the literature.

Brain Neoplasms↗
PubMed1981

Haber's syndrome. Report of a new family.

Three Japanese brothers had the rosacea-like facies and multiple intraepidermal epitheliomas that characterize Haber's syndrome. They also had xerosis of the lower extremities. The facial lesions were dry, warm, erythematous, and indurated, with enlarged follicular orifices and telangiectasia. One patient had disturbing "burning" of the face, which was relieved by short courses of steroid therapy that were given for systemic effects.

Adult↗
PubMed1981

In vitro microwave effects on human neutrophil precursor cells (CFU-C).

Human marrow cells were irradiated with 2450-MHz CW microwaves in a fluid-filled waveguide irradiation system. Cell exposure was conducted by placing a marrow cell suspension in 20-microliter glass microcapillary tubes were positioned in the exposure chamber, and irradiated at power densities from 31 to 1,000 mW/cm2 (with corresponding specific absorption rates of 62 to 2,000 mW/g) for 15 minutes. The temperature of the sample was maintained at a fixed point. Sham-irradiated (SI) and microwave-irradiated (MWI) cells were cultured in a methylcellulose culture system for neutrophil colony proliferation. There was no reduction in neutrophil colony number on days 6-7 or 12-14 in cells exposed at 31 or 62 mW/cm2, but as the power density was increased to 1,000 mW/cm2, there was a reduction in colony number of MWI cells compared with SI cells. The microwave interaction with the human neutrophil colony-forming cells was apparently not related to temperature rise, or to the state of cells cycle, and was irreversible.

Bone Marrow↗
PubMed1981

The prevention of iatrogenic spinal cord injury utilizing the evoked spinal cord potential.

The evoked spinal cord potential elicited by direct stimulation of the cord has been used clinically to monitor cord function in the course of operations on the spine. The technique used allows measurement of a relatively large amplitude of potential, which is fairly stable against anaesthetics and related drugs, by means of a simple recording system and is sensitive enough to indicate cord damage. Continuous monitoring can easily be carried out. We have encountered no complications when using this method on 99 patients.

Adolescent↗