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Biomedical subjects

S Imreh

Publications and source records attributed to S Imreh.

46 records · Page 3Linked to original sources
PubMedDate not supplied

[Pathogenetic forms of intersexuality states in children].

The present paper reports on 26 children with intersexuality states, belonging to the following pathologic forms: 1. female pseudohermaphroditism--11 cases, including a) type I congenital corticoadrenal hyperplasia (8 cases) and type III (1 case); b) iatrogenic form (1 case), and c) corticoadrenal virilizing adenoma (1 case); 2. male pseudohermaphroditism--6 cases, and 3. gonadal dysgenesis of female phenotype--9 cases of which a) Turner syndrome (6 cases); b) gonadal dysgenesis 45 XO/46 XX (2 cases) and c) Swyer syndrome (1 case). The authors emphasize the prenatal conditioned character (chromosomal or metabolic genetic diseases, congenital diseases) in the majority of the cases; they discuss the diagnostic criteria, therapeutical possibilities and prophylaxis as well as their efficiency which depends upon the moment the diagnosis is established.

Adolescent↗
PubMedDate not supplied

[Trisomy 22].

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Chromosomes, Human, 21-22 and Y↗
PubMedDate not supplied

Influence of thymic humoral factor(s) on haemopoiesis in mice.

Postirradiation administration of Leukotrophin to whole-body irradiated mice was associated with increased LD50/30 and DRF. As indicated by 59Fe uptake and ESC number, haemopoiesis was significantly stimulated in spleen and bone marrow after Leukotrophin application to irradiated mice. DNA content and the uptake of 3H-thymidine in DNA was significantly enhanced in the thymus and bone marrow of irradiated and Leukotrophin-treated mice. The micronucleus test confirmed that Leukotrophin is a therapeutic agents, while administered before irradiation it does not influence the initial radio-lesions.

Animals↗
PubMedDate not supplied

New data concerning the effects of 6-hydroxydopamine on the exercise performance in rats.

An injection of 250 micrograms 6-OHDA into the right cerebral ventricle of adult rats tested after 45 days led to a reduction of the run performance on the treadmill compared with the control group, but only in the first period of this test, repeated 10-11 times, every 2-3 days. This behavior was more obvious in male and in exercise-enduring rats. The histological examination proved partial destruction of central monoaminergic (especially dopaminergic) structures in the 6-OHDA treated rats. 24-48 hours after peripheral injections of 6-OHDA (100 mg/kg b. w.) a considerable reduction of the run and swim performance (acute exercise till exhaustion) occurred. Falck's histofluorescence method proved large destructions of the noradrenergic innervation in the iris; 6-OHDA injected i.p. into neonatal rats had similar effects.

Animals↗