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Biomedical subjects

S Imayama

Publications and source records attributed to S Imayama.

97 records · Page 6Linked to original sources
PubMed1984

Development of DTH skin reaction to HBsAg in individuals immunized with HB vaccine.

To examine the temporal relationship between the DTH skin reaction to HBsAg and antibody response to HBsAg, serial skin tests for HBsAg were carried out on seven individuals immunized with HB vaccine. All cases developed both a skin reaction and antibody response. In many cases, the DTH skin reaction appeared four weeks before the antibody response. These data suggest that DTH skin reaction may be a more sensitive method than humoral antibody assessment for monitoring the success of vaccination.

Adult↗
PubMed1984

Human psoriatic skin lesions improve with local hyperthermia: an ultrastructural study.

Electron microscopy of psoriatic skin prior to and after local hyperthermia revealed both temporary and gradual changes following treatment. The former occurred almost simultaneously with initiation of hyperthermia, and were characterized by an intracellular edema, the aggregation of tonofibrils in the basal half of the epidermis and an amorphous substance in the epidermal interspaces. The latter occurred during the course of treatment and were represented by narrowing of the intercellular spaces, a decrease in the number of mitochondria and free ribosomes, and an increased number of desmosomes and tonofibrils, with a consequent increase of keratohyaline granules. No such abnormal cells and structures were found in this study, as were observed in PUVA therapy.

Adult↗
PubMed1981

Scanning and transmission electron microscope study on the terminal blood vessels of the rat skin.

The microvasculature in the subepidermal layer of the rat foot was examined by scanning electron microscopy of corrosion casts and by transmission electron microscopy of serial ultrathin sections. Three-dimensional observation of the casts demonstrated that, in the walking pads (pressure areas) with a thick epidermis, terminal vessels formed tortuous capillary loops that penetrated vertically into well-developed dermal papillae. In other regions of the foot (non-pressure areas) with a thin epidermis, terminal vessels formed a horizontally arranged capillary network and each capillary of the network fitted into a shallow groove along the dermal epidermal boundary base. These differences in the pattern of vascular distribution might be of significance from the view point of the blood flow; in pressure areas, the vertically arranged, tortuous vessels might allow vertical mobility of the skin without injury to them and might keep the blood flow normal against the force of compression. In thin sections, however, capillaries of both the loops and networks were similar in spite of the differences in the vascular distribution and the architecture of the epidermal-dermal junction. Vessels located in close proximity to the epidermis exhibited endothelial fenestrations along their proximal margins. In vessels away from the epidermis, on the contrary, fenestrations were not apparent. Since endothelial fenestration is an anatomical property related to rapid material exchange, it may be concluded that the pattern of distribution and the fine structure of subepidermal capillaries adjusts to the metabolic needs of the epidermis.

Animals↗