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Biomedical subjects

S Im

Publications and source records attributed to S Im.

45 records · Page 3Linked to original sources
PubMed1990

An epidermoid cyst with a seborrheic verruca-like cyst wall.

The epidermoid cyst with a seborrheic verruca-like cyst wall is a newly described variant of the epidermoid cyst. The cyst wall of this variant shows changes simulating seborrheic keratosis and verruca. Our case of a subcutaneous mass was shown histopathologically to have this variant.

Adult↗
PubMed1989

Likelihood estimation of quantitative genetic parameters when selection occurs: models and problems.

Conceptual aspects of estimation of genetic components of variance and covariance under selection are discussed, with special attention to likelihood methods. Certain selection processes are described and alternative likelihoods that can be used for analysis are specified. There is a mathematical relationship between the likelihoods that permits comparing the relative amount of information contained in them. Theoretical arguments and evidence indicate that point inferences made from likelihood functions are not affected by some forms of selection.

Animals↗
PubMed1977

Metabolic studies on two patients with nonhepatic tyrosinemia using deuterated tyrosine loads.

Metabolic studies on two patients with defects in the tyrosine oxidation pathway are reported. Serum tyrosine was greatly elevated in both patients (1.37 and 1.52 mmol/liter, respectively) and both excreted large quantities of p-hydroxyphenylacetic acid, p-hydroxyphenyllactic acid, and p-hydroxyphenylpyruvic acid. Deuterated tyrosine loads were administered to both patients, before and after lowering of the serum tyrosine concentration by dietary treatment, and to a normal adult control subject. In one patient the excretion of the deuterated (D2)-tyrosine load was more than 300 times that found in the control subject whether the test was done at high or low serum tyrosine level and the pattern of metabolites indicated a persistent defect in p-hydroxyphenylpyruvic acid oxidase. Enzyme assays on needle liver biopsy supported this finding. In the second patient excretion of the D2 label was 300 times that of the control at high serum tyrosine levels, but only 5 times normal at low serum tyrosine levels. This finding was interpreted as indicating substrate inhibition of p-hydroxyphenylpyruvic acid oxidase. The primary defect has not been established in this patient, but the findings are compatible with a defect in hepatic-soluble tyrosine aminotransferase.

4-Hydroxyphenylpyruvate Dioxygenase↗