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Biomedical subjects

S Iijima

Publications and source records attributed to S Iijima.

At least 163 records · Page 9Linked to original sources
PubMed1990

[Rheological analysis of suppressed leukocytosis in patients with pregnancy induced hypertension (PIH)].

It is documented that the number of leukocytes in peripheral blood increases considerably during pregnancy. We observed that the range of leukocytosis differs in normal pregnancy differs from that in cases with severe pregnancy induced hypertension (PIH). The data obtained in our university hospital, for example, give the number of leukocytes after twenty-four weeks of gestation as 9,000 +/- 1,600/mm3 (mean +/- SD) for normal cases (93 measurements in 37 cases) and 6,600 +/- 1,100/mm3 for PIH (72 measurements in 18 cases; p less than 0.001). To elucidate the cause and relation to PIH, we studied changes in the activity of leukocytes during pregnancy by means of a modified Nuclepore filtration method (Kikuchi et al., 1983). The time required for leukocytes to squeeze through filter pores under constant suction varies greatly depending on their active states; more active cells show greater resistance to pore passage, which can be clearly shown by exposing cells to various stimuli. The filtration time for 0.5ml blood containing 5,000/mm3 leukocytes minus that of leukocyte poor blood with the same hematocrit was taken as an index of the activity, which we called the rheological activity of leukocytes (RAL). RAL values for blood taken at delivery were 3.4 +/- 1.5 sec for normal cases and 5.0 +/- 2.1 sec for PIH (N.S.). RAL values obtained after the addition of a chemotactic stimulant FMLP (formyl-methionyl-leucyl-phenylalanine) (10nM) to the same samples were 21 +/- 10 sec for normal cases and 405 +/- 265 sec for PIH (p less than 0.001). Leukocyte activity, particularly, response to chemotactic stimulation, was the before thought to be considerably increased in PIH.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

[The study on the specific eruptions of malignant lymphoma. I. Clinical, pathological and immunopathological characters].

We investigated 31 cases of cutaneous malignant lymphoma diagnosed by skin biopsy during about 11 years at the University of Tsukuba Hospital. The specific eruption was occurred in 17.7% of all malignant lymphomas at the hospital. The skin was primarily affected in 5.8% of all malignant lymphomas including Hodgkin disease, and in 6.9% excluding Hodgkin disease. We divided 31 cases into 3 groups; Group A is the primary cutaneous lymphoma, and Group B and C are the secondary cutaneous lymphoma. The skin lesions of Group B share the major part. On the other hand, that of Group C is minimal and transient. The differences between group A/B and group C were the high frequency of epidermotropism. The T cell dominance, the widespread eruption and the variety of the eruptions for one case in Group A/B. Group A differed from group B/C by the specific plaque, and from Group B by the high frequency of Pautrier's microabscess. B cell lymphomas did not show dermal-epidermotropism as well as epidermotropism.

Adult↗
PubMed1989

[Carcinoma of male breast--with special reference to noninvasive carcinoma].

Seven cases of carcinoma of male breast were reported. The mean age of them was about 65 years, 17 years older than that of female breast cancer. Six tumors out of 7 were located under the areola. By histological examination, 4 of 7 cases were proved to be noninvasive ductal carcinoma, and the others are invasive ductal carcinoma (2 : scirrhous, 1 : solid-tubular). We focused on clinicopathological features of noninvasive carcinoma. There were two points to be mentioned. One is the nipple discharge as a chief complaint, and the other is cyst formation as a macroscopic observation. These features are characteristic to noninvasive carcinoma and contribute to diagnosis. Therefore, for screening the mass of male breast, ultrasonography (U.S.) is most useful. For preoperative final diagnosis, aspiration or smear cytology is essential. In regard to postoperative survival, all of the 3 invasive cases were dead but all of the 4 noninvasive cases are alive. So the prognosis of noninvasive carcinoma of male breast does not appear to be worse than the female one. These observations indicate that the prognosis of carcinoma of male breast can be improved by early diagnosis and appropriate surgical therapy.

Aged↗
PubMed1989

Mitomycin-C-induced sister-chromatid exchanges and cell-cycle kinetics in lymphocytes from patients with Klinefelter syndrome.

The chromosomal sensitivity to mitomycin-C (MMC) and cell-cycle kinetics in cells from patients with Klinefelter syndrome, a sex chromosomal disorder giving a high risk of malignant tumor, were studied by techniques of sister-chromatid exchanges (SCEs). The frequencies of MMC-induced SCEs increased in proportion to the increase in MMC concentration in both patient and normal control cells. At low levels of MMC there were no significant differences in SCE frequencies between the patient and normal control cells, but at MMC concentrations of 3 X 10(-8) M (p less than 0.05) and 1 X 10(-7) M (p less than 0.01), significant increases in the frequency of MMC-induced SCEs were observed in cells from patients compared to cells from normal controls. Although the analysis of cell-cycle kinetics both after various culture times and after treatment with MMC revealed that there were no significant differences between the patient and normal control cells, patients with Klinefelter syndrome showed a tendency to cell-cycle delays after treatment with MMC in comparison with normal controls.

Cell Cycle↗
PubMed1989

Central effect of endothelin on blood pressure in conscious rats.

This study was conducted to investigate the effect of intracerebroventricular administration of endothelin (EDT), a novel potent vasoconstricting peptide, on blood pressure in conscious rats. The lateral cerebral ventricle of male Wistar rats was cannulated, and the femoral artery was also cannulated to measure the mean arterial blood pressure (MABP) and heart rate (HR). EDT dissolved in 10 microliters of artificial cerebrospinal fluid (ACSF) (8.25-66 pmol icv) provoked a dose-dependent increase in MABP. EDT also increased HR, although the effect of 66 pmol was variable. Intracerebroventricular ACSF did not provoke any effects on MABP and HR. Intracerebroventricular EDT also provoked contralateral rotational behavior. Pretreatment with 2 mg/kg iv phenoxybenzamine significantly suppressed the 16.5 pmol icv EDT-induced increase in MABP. Moreover, 16.5 pmol icv EDT markedly increased plasma epinephrine and norepinephrine concentration. These results indicate that EDT has a central pressor action, and the action might be mediated, at least in part, by catecholamine release to the periphery. EDT might play a role in the central control of blood pressure, although the physiological implications have not yet been determined.

Animals↗
PubMed1989

[Histopathological study of the effect of pure metals to the periodontal tissues].

In order to investigate biocompatibility of pure metals, which are widely used, the gingival tissues were brought into contact with pure metals. Nine kinds of pure metals, such as gold, platinum, silver, palladium, copper, nickel, zinc, indium and tin were used in the analysis of biocompatibility. With a No. 1/2 round bar, a standardized small cavity was prepared in the mesiolingual cervical portion of the upper first molar. Nine kinds of pure metals powder were inserted into the small cavity of the maxillary root surface in rats. Post operative changes of the gingival tissue were studied histopathologically. The results were as follows: 1. Gold, palladium and indium powder were observed in the lamina propria of the gingiva. Infiltration of cells was not observed around these pure metal powders. Gold, palladium and indium powders showed little cytotoxicity. 2. Zinc powders were not associated with chronic inflammatory charges. Zinc powders were surrounded by an abundance of connective tissue substances. The fragments were surrounded by collagen fibers, but no inflammatory cells were present. Zinc powders showed little cytotoxicity. 3. Platinum and tin powders were not associated with chronic inflammatory changes. These pure metal powders were surrounded by macrophages, but no other mononuclear inflammatory cells were present. 4. Clumps and granules of silver powder were not associated with chronic inflammatory changes. Multinucleate giant cells were shown surrounding silver powders. Silver powders were observed to have been taken into the multinucleate giant cells. Many of these cells also contained fine dark granules in their cytoplasm, and a few contained small pieces of silver. The tissue reaction to silver showed little cytotoxicity. 5. Copper and nickel powders were associated with chronic inflammatory cells. Moderate chronic inflammation and occasional neutrophils leucocytes and lymphocytes were shown to be associated with these pure metal powders. Copper and nickel caused extensive damage to the gingival tissues.

Animals↗
PubMed1988

Endogenous endotoxemia in patients with liver cirrhosis--a quantitative analysis of endotoxin in portal and peripheral blood.

In order to investigate the mechanism of endogenous endotoxemia (that is, endotoxemia observed in the absence of infection) in patients with liver cirrhosis, the concentration of endotoxin in the portal (PO-Et) and peripheral blood (PE-Et) from fifty three patients undergoing abdominal surgery was simultaneously measured by a quantitative endotoxin assay. The PE-Et of the patients with liver cirrhosis (19.8 +/- 20.2 pg/ml, n = 23) was significantly elevated, when compared with that of the patients without liver cirrhosis (9.2 +/- 5.1 pg/ml, n = 30), and was close to the normal range of PE-Et obtained from thirty healthy volunteers (7.2 +/- 4.1 pg/ml, n = 30). The PO-Et was also higher in the patients with liver cirrhosis than in the patients without liver cirrhosis. Moreover, PO-Et was significantly higher than PE-Et in all the patients (p less than 0.05). The per cent difference in the endotoxin concentration between the portal and peripheral blood (percentage of delta Et) was significantly decreased in the cirrhotic patients, especially in those with esophageal varices, which was well correlated with the phagocytic activity of the reticuloendothelial system (RES) determined by the clearance of iron colloid. The endogenous endotoxemia is thus likely to be due to the impaired clearance of endogenous endotoxin in portal blood, resulting from both the decreased phagocytic activity of RES in the liver and the coexisting porta-systemic bypass.

Endotoxins↗
PubMed1988

Two cases of acquired toxoplasmic lymphadenitis. Light and electron microscopic and immunohistochemical studies.

We report two cases of acquired toxoplasmic lymphadenitis, one with toxoplasmic cysts and the organisms of Toxoplasma gondii and the other with the organisms only. These cysts and organisms were observed in paraffin-embedded sections, touch smears and ultrathin sections for electron microscopy. Touch smears were especially valuable for the quick and accurate diagnosis of toxoplasmic lymphadenitis. We also studied immature sinus histiocytosis (ISH) in these cases. The predominant cells of ISH were confirmed to be B lymphocytes immunohistochemically, the majority being positive for polyclonal surface IgM. ISH was observed in the perifollicular and paracortical areas surrounding post-capillary venules (PCV), whereas the sinuses were only partially involved.

Adolescent↗
PubMed1987

Appearance of frontal mid-line theta rhythm during sleep and its relation to mental activity.

Fm theta occurred not only during mental tests in the waking state but also during nocturnal sleep in which it was most frequent during REM and secondarily most frequent during stage 1 of NREM sleep. As for the inner experience of the subjects, they frequently reported dream and distinct mentations on awakening from REM sleep whether or not it was accompanied by Fm theta. They reported dream and distinct mentations more frequently when awakened from stage 1 of NREM sleep with Fm theta than when awakened from stage 1 of NREM sleep without Fm theta. Relationship of Fm theta to mental activity during sleep was briefly discussed.

Adolescent↗
PubMed1987

Reticulate hyperpigmentation distributed in a zosteriform fashion: a new clinical type of hyperpigmentation.

We have recently seen two cases of hyperpigmentation in children, which was reticulate and distributed in a zosteriform fashion. As another two cases of hyperpigmentation of this kind in children have been reported previously, described as reticulate hyperpigmentation distributed in a zosteriform fashion, this gives a total of four cases of hyperpigmentation of this kind reported recently from Japan. These four cases differed from progressive cribriform and zosteriform hyperpigmentation, the condition which these cases resembled most closely, with respect to the age of onset of the hyperpigmentation, which in the four Japanese cases was not confined to a dermatome. Like a variant of incontinentia pigmenti (IP), all four cases showed eosinophilia. But they differed from IP in that there was no inflammatory stage, no pigmentary incontinence detectable on histology, and no evidence that the condition was hereditary. These four cases do not conform completely to any described entities and we suggest that they represent a new clinical entity.

Child, Preschool↗
PubMed1987

Regulation of the expression of proto-oncogene c-src by alternative RNA splicing in chicken skeletal muscle.

Expression of the c-src locus in skeletal muscle of the chicken was found to be different from other tissues. A 4 kilobases (kb) cellular src (c-src) mRNA, which most likely codes for pp60c-src, is expressed in various chicken tissues examined, and most of its approximately 2.2 kb non-coding sequences are present at the 3' end of the RNA molecule. Whereas the 4 kb RNA is also expressed in embryonic chicken muscle, it disappears shortly before hatching and is replaced by a smaller-sized class of c-src mRNAs of 2.8 to 3.3 kb. The transition of expression from the 4 kb to the 2.8-3.3 kb RNA in skeletal muscle occurs shortly before hatching of the chicken and persists into adulthood. The two classes of the c-src mRNA share sequences both within the 5' coding and the 3' non-coding regions of pp60c-src, however, the 2.8 to 3.3 kb RNA lacks most of the kinase domain, but it contains upstream c-src sequences missing in the 4 kb RNA. The two classes of c-src mRNA most likely are generated by alternative splicing, and the smaller c-src RNA most likely codes for a product other than tyrosine protein kinase.

Age Factors↗