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Biomedical subjects

S I Zolotukhin

Publications and source records attributed to S I Zolotukhin.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood].

With a single intravenous administration to albino rats of both sexes of nospanum and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this process. A protracted introduction by the subcuataneous route of halidor and nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the proteolytic process. It was found that in vitro nospanum, halidor and dibazol accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma deccelerates this process.

Aminophylline↗
PubMedDate not supplied

[Study of the induction of thrombocyte adhesiveness in the presence of heparin].

An investigation of the thrombocytes adhesion after Hellem (1960) showed that "in vitro" tests norepinephrine, epinephrine, histamine, serotonin and adenosine-diphosphate, when used in doses of 100-25,0 gamma/ml, were capable of raising the thrombocytes adhesion, while heparin administered in doses of 0.5-0.05 U/ml depressed and in a dose of 0.025 U/ml mildly activated this capacity of the thrombocytes. In the presence of heparin the ability of biogenic amines to induce the adhesion of thrombocytes decreased. Between concentration of the agents and the adhesive index of thrombocytes there exists a two-way logarithmic relationship. Intravenous administration of serotonin in a dose of 5 mg/kg and of epinephrine in an amount of 0.05 mg/kg to rabbits increased the adhesivity of thrombocytes, whereas intravenous introduction of 100 un/kg of heparin tended to greatly reduce it. On introduction of serotonin and epinephrine to rabbits against the background of heparin their ability to activate the thrombocytes adhesion diminished quite significantly. The logarithm of time lapsed from the instance of the heparin administration is linearly dependent on the logarithms of values characterizing the adhesivity of thrombocytes. Intravenous administration of norepinephrine and histamine in a dose of 0.5 mg/kg did not cause any changes in the adhesive properties of thrombocytes.

Adenosine Diphosphate↗
PubMedDate not supplied

[Action of nonachlazine on thrombocyte aggregation induced by adrenaline].

Nonachlazine at concentrations 10(-6)--10(-4)M inhibited platelet aggregation in rabbits induced by adrenalin in vitro. The same concentrations of the drug produced an appreciable increase in aggregation reversibility. Intravenous injection of nonachlazine into the rabbit 50 minutes prior to adrenalin protected the platelets against the aggregation activity of adrenalin but did not affect deaggregation.

Animals↗
PubMedDate not supplied

[Pharmacology of a new drug form, fenasal granules].

Experiments on mice and rats were made to study a new medicinal form, fenasal granules given per os and to compare it with ground tablets and powder of fenasal as regards the intestinal content, absorption capacity, anthelminthic activity and toxicity. The intestinal content and absorption capacity of fenasal were medicinal form-dependent. The highest anthelminthic activity was exhibited by fenasal granules. Acute toxicity of powder, ground tablets and granules of fenasal administered to mice and rats per os remained the same.

Absorption↗