Behaviour of Paramecium aurelia in solutions of purified and fluorescent labelled tetanus neurotoxin.
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Biological Assay↗
Biomedical subjects
S I Zacks
Publications and source records attributed to S I Zacks.
Studies on tetanus. IV. Intramitochondrial dense granules in skeletal muscle from human cases of tetanus intoxication.
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Humans↗
Myopathies related to diabetes mellitus and other metabolic diseases.
Although it has long been known that both large and small blood vessels are abnormal in the tissues of diabetic patients, recent work has emphasized the widening of capillary basement membranes in diabetic tissues. Current views of the nature of this lesion and its relationship to diabetes are discussed and diabetic muscle and nerve lesions are emphasized. Other metabolic diseases with significant muscle pathology are types II, III and VII glycogen storage diseases. Myopathy with abnormal mitochondria is reviewed.
Basement Membrane↗
Pathology of the neuromuscular junction.
Diagnosis of neuromuscular disease by the study of motor endplate structure in the light and electron microscopes is probably one of the most specialized examinations in the field of neuropathology. The classical means of staining endplates using gold, silver or methylene blue are described as well as more modern techniques suitable for light microscopy. Specific abnormalities in patterns of terminal innervation after methylene blue staining are noted. Techniques for localizing endplates suitable for electron microscopic study are given and some of the typical changes that occur in endplate structure in some neuromuscular diseases are indicated.
Biopsy↗