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S Houry

Publications and source records attributed to S Houry.

At least 91 records · Page 5Linked to original sources

[Autotransplantation of islets of Langerhans in the rat using a new method of isolating the islets].

The limiting factor of efficacy of islet of Langerhan's grafting for the treatment of diabetes is the number of islets available, the majority of isolation techniques used being chemical and wasteful. Animal studies have shown that 3 or 4 pancreases must be used to obtain a sufficient number of islets to correct an induced diabetes. A simple, totally mechanical method of their isolation was developed allowing a sufficient number of islets to be collected from a single pancreas for effective therapy of diabetes induced by total pancreatectomy in the rat. The same method can be applied to humans.

Animals↗

[Sigmoid duplication in an adult].

Duplications of digestive tract are usually observed in new-born. In most of the case they are located on the small bowel. We observed, in a 69-year old man which complained of abdominal distension and constipation a sigmoid duplication. A colectomy was performed. Carcinoma arising in such duplication have been reported.

Aged↗

[Choledochoduodenal anastomoses in biliary lithiasis].

In choledocholithiasis, after opening the common bile duct, we used to perform choledochoduodenostomy in old patients. The aim of this study was to evaluate our results in 77 patients. The mean age of the patients was 75 years. Twenty-two patients were operated for angiocholitis, 19 had jaundice, and 36 had gallstones without angiocholitis or jaundice. There was two hospital deaths (2.6 p. cent). All the patients but two could be traced. The mean follow-up was 6.7 years. Two patients had had transients episodes of angiocholitis. Twenty-five patients have dead. Expected mortality in french population corresponding in age and sex was 29 deaths. Our results suggest that choledochoduodenostomy is a safe and effective procedure in the management of calculous biliary tract disease for old patients.

Aged↗

Choledochoduodenostomy for calculous biliary tract disease.

After the opening of the common bile duct, several controversial procedures may be used. In choledocholithiasis, our preference is to perform choledochoduodenostomy in older patients. We report the results in 77 consecutive patients with a mean age of 75 years. There were two hospital deaths (2.6%). Follow-up ranged from six months to 15 years, with an average of 6.7 years. Fifty patients are alive and well. Twenty-five patients have died. Only two patients were unavailable for follow-up. Expected mortality in the French population corresponding in age and sex was 29 deaths and the overall survival is not different, including the two postoperative deaths. Delicate technique allows anastomoses to ducts of any size, with no difference in long-term survival compared with a French population similar in age and sex.

Aged↗

[Acute pancreatitis and biochemical markers. Isoamylase].

Amylase activity in blood and urine, lipase activity in blood, and amylase/creatinine clearance ratio have been prospectively compared in order to test these parameters against estimation of pancreatic isoamylase. Pancreatic isoamylase had been evaluated by inhibition methodology and not by electrophoresis. One hundred patients admitted for strictly sus-umbilical abdominal pain in emergency unit have been studied. Results show that we do not have in blood specific biochemical marker for acute pancreatitis. Lipase and P isoamylase activity evaluation have about the same specificity. In emergency situation the choice of routine investigation will be rather based on methodological simplicity and lower cost.

Acute Disease↗

[Spontaneous rupture of the spleen in chronic pancreatitis].

Excepting splenomegaly related to segmental portal hypertension, splenic complications observed during the course of chronic pancreatitis are uncommon. These may include splenic necrosis, intrasplenic pseudocysts and splenic rupture. Spontaneous rupture of the spleen is one of the least common events, a total of 29 cases being reported thus far. We present herein 4 new cases, and previously documented cases were reviewed. In our cases, the splenic rupture occurred in young male patients. This complication revealed the pancreatic disease in one case while in the others, it occurred on the average 7 months after the symptomatic onset of pancreatic disease. This suggests that this complication occurs early in the natural history of chronic pancreatitis. The mechanism of the splenic lesion remains unclear, the different causes advanced, mechanic, enzymatic or vascular, are discussed. None of our patients had minimal trauma emphasizing the spontaneous character of rupture. Diagnosis was a surgical discovery except in one case in which selective arteriography was of most valuable aid in confirming diagnosis preoperatively. Treatment was simple splenectomy in 2 cases and associated with distal pancreatectomy in the 2 other cases. Recovery was uneventful. A corporal pancreatic pseudocyst was treated at the same time.

Adult↗

[Cancer of the gallbladder].

Of 21 patients with primary carcinoma of gallbladder the diagnosis has been considered before operation in three. Nine patients underwent laparotomy only, six a palliative resection, and six a curative resection. In these three groups, 17 patients died. The mean survival time was respectively 1.5.4.3, an 8.6 months. Four patients are alive. Three of them had a resection for a carcinoma limited to the wall of gallbladder. Two patients had radiation therapy, one after palliative resection (died 11th month), the other one after biliary and digestive by-pass (alive with a follow-up of 15 months). Three patients had dosages of carcino-embryonic antigen. Our experience suggested that: diagnosis may be suggested by echography, The usefulness of carcino-embryonic-antigen levels, radiotherapy may increase the effectiveness and length of palliation.

Adult↗

[Total splenopancreatectomy in the rat].

Techniques previously described for the performance of total splenopancreatectomy in the rat have consisted of freeing of pancreatic lobules from their vascular and biliary attachments. A new procedure is described for total pancreatectomy in which block excision is made of the spleen, the pancreas and the intrapancreatic common bile duct. The latter is then reimplanted into the duodenum by intubation as described during liver transplants. This operation was performed in 12 rats and appeared to be technically simpler to conduct than other procedures. It avoids leaving some pancreatic lobules in place, particularly those lying along the common bile duct, and induced a severe diabetes in all the animals.

Animals↗

Total splenopancreatectomy in the rat. Technical report.

The techniques of total pancreatectomy previously described in the rat, separated the pancreatic lobules from their vascular and biliary connections. The technique described is an en bloc resection of the spleen, the pancreas, and the intrapancreatic common bile duct. The common bile duct is reimplanted in the duodenum by intubation, as described previously in liver transplants. This technique, performed in 12 rats, realised a more complete pancreatectomy than techniques described previously.

Animals↗

[Should preventive antibiotics be prescribed in surgery of the appendix, biliary tract, stomach and duodenum?].

Most infections occurring after biliary or gastrointestinal surgery are caused by dissemination of organisms present in the lumen of the biliary or the gastrointestinal tract at the time of operation. Randomized prospective studies have been performed with antibiotics active against organisms usually found in wound infections. Results have shown that cephalosporin, lincosamide and imidazole in appendicectomy, aminoside, cephalosporin, lincosamide and sulfamide in biliary surgery, and cephalosporin in gastro-duodenal surgery decreased wound infections. These results and prediction of wound sepsis following operations suggest a discriminate use of antibiotic prophylaxis in appendicectomy, gastro-duodenal and biliary tract surgery.

Anti-Bacterial Agents↗

[Choledochocele in adults].

Choledochocele are cystic polypoid lesions of the end portion of the common bile duct. The occurrence of choledochocele is 4 p. cent among choledochal cysts. One case is presented in a 78-year-old woman. The treatment was surgical excision. This case was unusual by the age of the patient and by the diagnosis missed at the time of a cholecystectomy performed one year previously.

Adult↗

[Gallbladder distomatosis. Echographic picture].

A 21 years old man presented biliary colic. Ultrasonography showed in the gallbladder an homogeneous, solid mass, 4 cm large, without acoustic shadowing and no postural movement. The increase of eosinophilic blood cells suggested the diagnosis of distomiasis of the gallbladder. The diagnosis has been confirmed by immunofluorescent test and surgery.

Adult↗

[Manual colorectal anastomosis. Immediate results (author's transl)].

Colorectal anastomosis with a single row of interrupted silk sutures was carried out in 105 patients, 37% of whom were older than 70. Eighteen per cent were operated upon for obstruction and/or perforation of the large bowel. Two patients died from disrupted sutures shortly after the operation, giving an overall post-operative mortality rate of 1.9 per cent. Two of the 103 patients who survived developed anastomotic fistulae. The most important measures to decrease mortality and morbidity in colorectal anastomosis are the choice of the appropriate technique in emergency surgery and meticulous performance on the anastomotic sutures.

Aged↗