OBJECTIVE: To describe how a sample of women in the Women's Health Initiative Dietary Modification Trial (WHIDM) labeled a healthy eating pattern and to compare these labels to their dietary maintenance. DESIGN: Participants completed a food frequency questionnaire and were divided into two maintenance groups, based on the percentage of energy derived from fat in their diets. Individual, semistructured interviews with the same subjects elicited information on labels they use to describe a healthy eating pattern. SUBJECTS/SETTINGS: Subjects were 100 postmenopausal women, 50 to 79 years of age, free of breast and colorectal cancer, and participating in a dietary intervention that consisted of 20% or less energy from fat. MAIN OUTCOME MEASURES: Percentage of energy from fat in the diet and labels used to define a healthy eating pattern. STATISTICAL ANALYSES PERFORMED: Multivariate analysis. RESULTS: The label "consistent/patterned" was a predictor of dietary nonmaintenance (p <.05). IMPLICATIONS: Future studies should use this information to re-educate nonmaintainers on compliance issues.

Aged↗

PubMedDate not supplied

Development of analytical methods for the detection of metaraminol in the horse.

Aramine (metaraminol bitartrate) has been found in the possession of horse trainers and veterinarians who have been investigated for possible inappropriate drug administration to racing horses. Metaraminol (3-hydroxyphenylisopropanolamine) is a sympathomimetic amine that directly and indirectly affects adrenergic receptors, with alpha effects being predominant. Because it has the potential to affect the performance of a racing horse, its use is prohibited. In the present study, methods for the detection of metaraminol were developed. Metaraminol was found to be extracted with poor recovery (< 50%) from aqueous solutions by routine basic extraction or cation exchange/reversed-phase solid-phase extraction techniques. However, an extractive acetylation method gave good (> 90%) recovery of metaraminol from aqueous samples. Sequential urine samples collected from horses administered metaraminol intramuscularly at 0.02, 0.10, and 0.23 mg/kg were extracted by the developed extractive acetylation procedure and analyzed by gas chromatography-mass spectrometry (GC-MS) in full-scan and selected ion monitoring modes. Norphenylephrine was used as an internal standard for quantitative analysis. The maximum concentration of metaraminol occurred between 1 and 2 h postadministration. Metaraminol was detected in the 0.23 mg/kg administration urine for 24 h postadministration. Metaraminol was detected for the 0.10 and 0.02 mg/kg doses for approximately 8 h postadministration. No apparent biotransformation products were observed in a reaction mixture of metaraminol and horse liver microsomal reaction mixture. Comparison of gas chromatograms of the extracts of the postadministration urine samples with those of the pre-administration samples failed to reveal any exogenous compound other than metaraminol.

Adrenergic Agents↗

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Watchful eye.

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Ethics, Nursing↗

PubMedDate not supplied

It's not natural.

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Attitude of Health Personnel↗

PubMedDate not supplied

Under lock and key.

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Attitude of Health Personnel↗

PubMedDate not supplied

Epilepsy: advances in anticonvulsant drugs.

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Anticonvulsants↗

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A guide to calcium channel blockers.

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Calcium Channel Blockers↗

PubMedDate not supplied

The revolution that wasn't: health care's role in the 1992 elections.

Ever since Harris Wofford won a U.S. Senate seat in Pennsylvania in November 1991 largely by calling for national health insurance, health reform has been considered a "top-tier" issue. But post-1992 election polls reveal that while Americans have remained disenchanted with the current system, they have not refined their views on reform much further. Because the issue is so complex and because specific proposals involve so many trade-offs, the best course of action for candidates in the 1992 races was to echo voter dissatisfaction and signal a desire for reform without stating specifics.

Attitude to Health↗

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