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Biomedical subjects

S Hontela

Publications and source records attributed to S Hontela.

36 records · Page 2Linked to original sources
PubMed1975

Triiodothyronine turnover in hospitalized psychogeriatric patients.

In a group of 12 hospitalized psychogeriatric patients, the fractional triiodothyronine (T3) turnover rate was significantly higher than in healthy control subjects of the same age, whereas the thyroxine (T4) turnover rate and other aspects of pituitary-thyroid function were virtually similar in both groups. Despite the presence of manifestations of sympathetic overactivity or hypermetabolism, the patients did not have true hyperthyroidism, as verified by the laboratory findings and the results of antithyroid treatment. The increases T3 turnover in aged hospitalized patients with brain disorders may be a compensatory mechanism which develops under these particular circumstances in order to maintain neurohormonal homeostasis. An alternate possibility is that the increased T3 turnover is secondary to hyperkinesis.

Aged↗
PubMed1975

Uncontrolled diabetes in psychogeriatric subjects.

In a group of 20 long-term psychogeriatric patients with uncontrolled diabetes, data on body weight, blood pressure and blood sugar concentration (fasting and postprandial) were correlated with the electroencephalographic (EEG) findings. The patterns were similar for the study subjects and for healthy subjects of the same age. The psychogeriatric patients with diabetes in contrast to psychogeriatric patients with chronic hypoglycemia, showed an increase in body weight and blood pressure and increase in blood sugar concentration with ageing; they also showed a normal EEG whereas chronically hypoglycemic patients usually had an abnormal EEG. In terms of blood glucose levels and excess glucose in the urine despite treatment, the diabetes had to be considered uncontrolled. However, these patients were clinically asymptomatic. Apparently, in these particular circumstances, the diabetes may be an adaptive biologic phenomenon.

Aged↗
PubMed1975

A psychogeriatric assessment program. II. Clinical and laboratory findings.

In a Psycholgeriatric Assessment Program, the statistical evaluation of clinical and laboratory data related to thyroid function in 80 patients led to the conclusion that: 1) differences in thyroid function between psychogeriatric patients of the organic and functional types were only slight, as determined by clinical symptoms and thyroxine blood levels, and 2) factor analysis for 53 selected variables indicated that loading for "gross disturbance of psychobiologic function" may be related to the symptom complex of hyperthyroidism/hyperadrenergism, and particularly to psychobiologic symptoms rather than purely somatic symptoms of hyperthyroidism. In comparison with a group of 60 healthy old people, the psychogeriatric patients showed many more signs of hyperactivity and other characteristics of this symptom complex. The results supported the preliminary impression of an energetic (hyperthyroid-sympathicotonic) reaction to mental decline, accompanied by plasma corticosteroid and electroencephalographic changes.

Adrenal Cortex Hormones↗