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Biomedical subjects

S Honjo

Publications and source records attributed to S Honjo.

At least 145 records · Page 8Linked to original sources
PubMed1977

[Changes of the uterine size during pregnancy in cynomolgus monkeys (Macaca fascicularis) (author's transl)].

This paper describes changes in the uterine size during the normal course of pregnancy in cynomolgus monkeys. Twenty-four females which had conceived by 3-day individual mating with a male were laparotomized 4,5,6,7,8,9,10,15 and 20 weeks after conception. The width, thickness and length of uterus were measured by a pair of callipers. Them, the uterine volume was estimated by the formula, V = 4/3 piab2 (a, b: uterine length x 1/2, uterine width x 1/2). The increase in the uterine width (y) during pregnancy could be expressed as a linear equation: y = 0.35x + 1.48 (x: weeks after conception). The thickness of pregnant uteri could be represented by a a linear equation: y = 0.36x + 1.40. From the 4th to the 20th week of pregnancy, the uterine length increased along a straight line expressed as a linear equation: y = 0.58x + 1.14. Except for nonpregnant uteri, the change in the uterine volume after pregnancy could be expressed as a linear logarithmic equation: log y = 2.319 log x -0.315. These 24 pregnant monkeys had followed the normal course of gestation until the time of laparotomy without any abnormality in their fetuses of their placentas, indicating that the values obtained throughout this study are of practical use for taking care of pregnant cynomolgus monkeys.

Animals↗
PubMed1976

Chemical composition of cynomolgus monkey milk.

Milk samples from eight cynomolgus monkeys whose lactation period ranged 44-119 days were investigated for their gross chemical composition such as total solids, crude protein, lipids, lactose and ash. Nitrogen distribution, compositions of fatty acids, amino acids and triglycerides as well as major minerals were also determined. These analytical data were compared with those reported for man, simian and cow, and cynomolgus monkey milk was found to have close similarities to human milk.

Amino Acids↗
PubMed1976

Oral glucose tolerance test in the cynomolgus monkey (Macaca fascicularis).

The glucose tolerance test was simplified so that it could be performed on more than one cynomolgus monkey (Macaca fascicularis) at a time. Glucose was administered orally in a dose of 2 g/kg body weight as a 50% aqueous solution, and blood samples were taken just before and 30 minutes and 150 minutes after glucose administration. The simplified test was conducted on a total of 93 cynomolgus monkeys. Glucose tolerance curves obtained by this method were classified into three patterns with regard to the increasing rate of serum glucose concentration per minute and the decreasing rate. Seventy-one monkeys showed the first pattern characterized by an increasing rate of 1.0 mg/min or more and a decreasing rate of 0.2 mg/min or more. The second pattern showing an increasing rate of 1.0 mg/min or more and a decreasing rate of less than 0.2 mg/min was obtained with 10 monkeys. The remaining 12 monkeys exhibited the third pattern in which the increasing rate and the decreasing rate were less than 1.0 mg/min and 0.2 mg/min, respectively. The first pattern is considered to be normal glucose tolerance, while the second and third patterns are regarded as abnormal ones. The incidence of the abnormal patterns was significantly higher in wild-imported cynomolgus monkeys than in laboratory bred monkeys.

Animals↗