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Biomedical subjects

S Holck

Publications and source records attributed to S Holck.

At least 55 records · Page 3Linked to original sources
PubMed1987

Neurogenous hyperplasia leading to appendiceal obliteration: an immunohistochemical study of 237 cases.

A series of 237 appendices was studied immunohistochemically for neurogenous hyperplasia. This was observed in 195 cases. It was possible to trace a continuum from appendices with intact lumens, featuring intramucosal neurogenous hyperplasia often with co-existent submucosal and muscular nerve growth, to obliterated specimens whose axial portions were composed of varying proportions of nerve tangles and fibrous tissue. Predominantly fibrotic specimens were considered as end-stages of this process. Stromal, argyrophilic cells lying amidst the nerve elements were prominent in the early, non-obliterated cases; their number decreased in the obliterated nerve rich specimens and such cells became inapparent in the late fibrotic stage. Repeated minimal subclinical attacks of inflammation are thought to trigger this lesion.

Adolescent↗
PubMed1987

Campylobacter pyloridis in peptic ulcer disease. I. Gastric and duodenal infection caused by C. pyloridis: histopathologic and microbiologic findings.

In this study 153 patients with dyspepsia were biopsied in the gastric antrum and duodenum. All specimens were investigated histopathologically and microbiologically for the presence of Campylobacter pyloridis, and the type of inflammation was recorded in accordance with Morson's criteria. C. pyloridis was found beneath the mucus close to the epithelial cells and mostly in connection with granulocytic infiltration (active gastritis). C. pyloridis was cultured from all of 10 patients with histologically active gastritis and active duodenitis, in 86% of 64 patients with active gastritis and morphologically normal duodenum, and in only 5% of 79 patients without morphologic gastric and duodenal changes. The close relation between active gastritis and C. pyloridis shows that C. pyloridis plays an important role in gastric inflammation, as it fulfils the criterion for a localized bacterial infection.

Adolescent↗
PubMed1987

Laminin in the anterior pituitary gland of the rat. Laminin in the gonadotrophic cells correlates with their functional state.

The distribution pattern of laminin in the rat anterior pituitary gland under physiological and hormonally altered conditions was studied immunohistochemically. Intense immunoreactivity of the capillaries and of the basement membranes surrounding parenchymal cells was found. Five to 10% of the parenchymal cells of normal adult rat pituitary gland exhibited also intense positive cytoplasmic staining. These were identified as gonadotrophic cells on the basis of their topographic distribution and typical 700-nm light bodies. By immunoelectron microscopy it was shown that the light bodies contain laminin and tubulin. After treatment with estrogen, which is known to suppress the function of the gonadotrophic cells, virtually no cytoplasmic laminin was found. Ultrastructurally, the number of light bodies in the gonadotrophic cells diminished significantly, from approximately 3 to 8 per cell to 0 to 1 per cell in a given section. In contrast, after castration, the number of laminin positive cells increased to a number above that found in the normal adult male rat, and the number of light bodies increased two to four times. Based on these results, it appears that the presence of cytoplasmic laminin and the number of light bodies reflects the hormonal activity of the gonadotrophic cells of the rat pituitary gland.

Animals↗
PubMed1986

Intercellular deposits of basement membrane material in active human pituitary adenomas detected by immunostaining for laminin and electron microscopy.

Thirty-eight human pituitary adenomas (24 endocrine active and 14 endocrine inactive tumors) were studied immunohistochemically for the presence of the basement membrane component, laminin, and ultrastructurally for the presence of basement membrane. Immunoreactivity of laminin delineated staining of epithelial and endothelial basement membranes, the reaction product being confined mostly to the perivascular zones. Moreover, a hitherto undescribed presence of intercellular laminin-positive droplets was observed in ten of the active adenomas (nine patients with hyperprolactinemia and/or acromegalia and one patient with Cushing's syndrome). Concurrently, at the ultrastructural level, bunches of basement membrane-like material intermingled between the adenoma cells were demonstrated in seven of these ten active adenomas. Furthermore, secretory granules were entrapped occasionally in this intercellular matrix, indicating a mutual dependence between excessive hormone extrusion and an increase of "misplaced" deposits of basement membrane components, e.g., laminin.

Adenoma↗
PubMed1986

Oral contraceptives and cancer.

The use of combined oral contraceptives has been shown in a number of studies to alter a women's risk of developing some kinds of cancer. Specifically, a 50% reduction in the risk of both ovarian and endometrial cancer has been demonstrated. This protective effect appears to persist for some time after oral contraceptives are stopped. Combined oral contraceptives do not appear to effect substantially the overall risk of developing breast cancer, although some data suggest that selected subgroups of women may be at a greater risk of developing breast cancer if oral contraceptives are used at specific times in a woman's reproductive life, especially if used for long periods of time. However, the data are not entirely consistent on this issue. The effect of oral contraceptives on the risk of developing cervical cancer is also not entirely clear, although the data available suggest a slightly increased risk of intraepithelial cervical cancer with prolonged use of oral contraceptives.

Adolescent↗
PubMed1986

Silent pituitary adenomas. An ultrastructural study.

Thirty cases of silent pituitary adenomas were studied clinico-morphologically and classified into 4 groups according to their fine structural characteristics. Tumors poor in organelles (7 cases) and typical oncocytomas (6 cases) produced pituitary insufficiency significantly more frequently than did tumors with moderately oncocytic changes (10 cases) and non-oncocytic, organelle-rich adenomas (7 cases). The latter 2 groups were more prone to proliferate suprasellarly. Postoperative, short-term follow-up studies showed that intrasellar disease was common in all groups, whereas suprasellar disease was more frequent among the latter 2 than in the former 2 types of adenomas. Hence, it seems possible from the fine structure to deduce a subgrouping of clinical significance.

Adenoma↗
PubMed1985

Dermatofibrosarcoma protuberans of the vulva.

A woman aged 52 years had a tumor of the mons pubis. The morphologic picture, featuring a whirling of spindle cells with long slender, interdigitating cell processes and so-called labyrinth nuclei, conformed to a dermatofibrosarcoma protuberans. Wide local excision is sufficient therapy, but more experience with this rare sarcoma of the vulva is necessary.

Cell Nucleus↗
PubMed1984

Elephantiasis neuromatosa. A light, immunohistochemical and electron microscopic study.

An example of elephantiasis neuromatosa, an unusual variant of neurofibromatosis, coexistent with lipomatosis is presented. This dual cell population produced a diffuse swelling of the gluteal sulcus of a young female. The neurogenous origin of the spindle cell component was substantiated by immunoreactivity for S-100 protein as well as by the fine structural observation of a regular basement membrane coating and a profusion of Luse bodies. As far as can be ascertained, this is the first reported immunohistochemical and ultrastructural study of this particular variant of peripheral nerve sheath lesion.

Adolescent↗
PubMed1983

Prolactinoma coexistent with granulomatous hypophysitis.

A 54-year-old man with a long-lasting left-sided headache and biochemical evidence of hyperprolactinemia was found to have a large chromophobe pituitary adenoma, which concurred with a granulomatous hypophysitis. The mechanism of the inflammatory reaction is discussed and the immunohistochemical and ultrastructural findings of this hitherto undescribed combination of lesions are presented.

Adenoma, Chromophobe↗
PubMed1983

Verrucous carcinoma of urinary bladder.

A seventy-five-year-old man with a four-month history of dysuria had a verrucous squamous carcinoma harbored within a bladder diverticulum. Whereas this low-grade malignancy occasionally develops in bilharzial specimens, its occurrence in schistosome egg-negative bladders is distinctly uncommon, having been the subject of only 1 previous case report.

Aged↗
PubMed1982

Healing of microvascular anastomoses. A comparative study using normal and irradiated recipient vessels for experimental free flaps in rabbits.

A comparative study was undertaken to evaluate the possible effect of previous radiotherapy on the healing of subsequently performed microvascular anastomoses between irradiated recipient vessels and normal flap vessels in rabbits. Radiotherapy was given preoperatively to a single anterior neck field using a Cobalt 60 unit, 1.25 MeV, SSD 80 cm in a fractionated dose corresponding to 5,000 rad/5 weeks. An experimental model using paired data was established using two epigastric free island flaps in each animal: one anastomosed to the irradiated vessels (carotid artery and jugular vein) and the other anastomosed to the normal opposite femoral vessels. Results did not show any marked difference in the healing pattern during the first 3-week period postoperatively except for a higher rate of thrombosis, when irradiated recipient vessels were used in end-to-end anastomoses, while no difference in healing pattern or rate of thrombosis were found using telescoped arterial anastomoses.

Animals↗