Improved method for cloning human B-cell lines.
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Adult↗
Biomedical subjects
S Hoch
Publications and source records attributed to S Hoch.
Monocyte receptor function in patients with rheumatoid arthritis.
Monocytes from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and normal volunteers were studied for abnormalities of Fc and C3 receptor function. Monocytes from the majority of 22 patients with active RA showed enhanced E-rosette formation and Ea phagocytosis compared to monocytes from 20 normal volunteers and 10 OA patients, However, no significant differences in binding of EAC or uptake of iodinated aggregated gamma globulin were found among the 3 groups. Corticosteroid-treated RA patients exhibited significant depression of EA-rosette formation and phagocytosis. These results suggest that there is modulation of EA receptor function in monocytes from RA patients.
Adult↗
[Role and task of the midwife in various countries].
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Africa↗
[Letter from Africa].
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Education, Nursing, Diploma Programs↗
Flushable stent-system for internal drainage in occlusive jaundice.
The effectiveness of biliary stents may be reduced as a result of obstruction by tumor material, bile salts or detritus. To circumvent this problem we developed a prosthesis system, which allows flushing and repetitive radiological control via a subcutaneous port. Prostheses were implanted in 26 patients presenting with inoperable occlusive lesions of the bile duct. Patency was regularly monitored by checking the bilirubin and alkaline phosphatase levels and using port-cholangiography. Catheter function was easily maintained in 92% of the patients and ended upon malignancy related death. In case of dysfunction, drainage could generally be restored with intensive flushing. This new flushable stent-system was easily implantable, could be exchanged without renewed percutaneous transhepatic puncture and allowed flushing, external drainage, bile probes for bacteriological examinations and follow up cholangiography via the subcutaneous placed port.
Cholestasis↗
Methylprednisolone pulse therapy for lupus nephritis: a followup study.
Eight patients with acute exacerbations of lupus nephritis were treated with nine courses of alternate day intravenous methylprednisolone pulse therapy, for three doses of 30 mg/kg/day. They were followed for 24 to 68 months (mean 35.6) post pulse. Stabilization of renal function was observed. Proteinuria declined, antinuclear antibody titers fell and low serum complement levels improved. Steroids were discontinued by 24 months in four patients, and switched to alternate day therapy in the remaining five patients. No patient required the addition of cytotoxic therapy. Transient post pulse elevation of serum creatine was observed with return to pre pulse renal function by 1 month. Exacerbation of hypertension in two of the four known hypertensive patients occurred during pulse therapy; in one patient, this was associated with angina. No other untoward side effects were observed. In our experience, pulse therapy is an effective form of treatment in a subset of patients with lupus nephritis who have had recent worsening renal function. Pulse therapy may allow such patients to avoid the hazards associated with conventional long-term high dose oral corticosteroids as well as those of cytotoxic agents.
Adolescent↗