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Biomedical subjects

S Heyden

Publications and source records attributed to S Heyden.

143 records · Page 8Linked to original sources
PubMedDate not supplied

Cardiovascular mortality in transient ischemic attacks.

Statistical analyses were made of the mortality of persons diagnosed as having definite TIA in an epidemiologic survey of a biracial Southern community. None of the usual risk factors associated with this illness such as heart disease, hypertension or diabetes appears to account for the excess deaths observed in a 10 year period of follow up.

Actuarial Analysis↗
PubMedDate not supplied

Effect of coffee on cholesterol and apolipoproteins, corroborated by caffeine levels.

The possibility that coffee may increase cholesterol levels has created uncertainty among physicians. The confusion arose from cross-sectional studies, in which female coffee drinkers appeared to show a positive association more frequently than men. To clarify this relationship, we designed an intervention trial to reduce caffeine and coffee intake sequentially while measuring total cholesterol and the apolipoprotein A-I and B levels. We conducted the study among women who were coffee drinkers (n = 35) or not coffee drinkers (n = 28). The trial spanned seven months with caffeine-free and coffee-free intervals. Serum caffeine levels corroborated compliance with the dietary protocol. Analysis of the apolipoprotein levels confirms the absence of any influence of coffee on lipoproteins in normocholesterolemic persons. We observed no apparent causal association of coffee or caffeine consumption and cholesterol and apolipoproteins.

Adult↗
PubMedDate not supplied

The P-wave in the electrocardiogram of hypertensive patients before and after therapy.

P-wave areas in the electrocardiogram (ECG) of 51 patients with hypertension and of 53 normotensive controls were measured in lead V1 using a computerised planimeter. The total area (in mm2) of P-waves was significantly larger in hypertensives than in normotensives, i.e. males 0.59 vs 0.31; females 0.55 vs 0.26 (p less than .0001) respectively. With exception of one male, the P-waves in hypertensives were either negative or biphasic with terminal negativity. In part 2 of the study, P-wave areas of 84 hypertensives were measured prior to and five years after treatment. The patients had no previous antihypertensive therapy, a diastolic blood pressure (DBP) 90-104 mmHg at the onset of the study, no ECG signs of left ventricular hypertrophy (LVH), and DBP less than 85 mmHg at the end of the trial. After five years, the mean values of the P-wave areas (in mm2) decreased in white males from 0.67 to 0.36; in white females from 0.63 to 0.42; in black males from 0.97 to 0.56; and in black females from 0.80 to 0.46. We conclude that ECG P-wave area is significantly larger in untreated hypertensives compared with normotensives. In successfully treated hypertensives, the P-wave area returns to normal values.

Blood Pressure↗