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Biomedical subjects

S Herman

Publications and source records attributed to S Herman.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Treatment for mental illness and substance abuse in a public psychiatric hospital. Successful strategies and challenging problems.

Although the literature on dual diagnosis has grown considerably over the last several years, report describing inpatient treatment models are less common. We describe some of the major treatment concerns in the dural diagnosis literature, such as using 12-step self-help programs like Alcoholics Anonymous (AA) or Narcotics Anonymous (NA), dealing with different stages of treatment, and developing a program with integrated substance abuse and psychiatric treatment. The practical application of these treatment issues is featured by showing how they are incorporated into an innovative inpatient dual diagnosis treatment program at a public psychiatric hospital. Finally, the treatment program is described in detail regarding administrative issues, staff training, daily treatment schedules, and patient demographics.

Adult↗
PubMedDate not supplied

Synthesis of dextran derivatives with thiol-specific reactive groups for the preparation of dextran-protein conjugates.

A novel strategy is described for the preparation of dextran-protein conjugates containing disulfide linkages. "Dormant" protected thiol groups are introduced as side chains on dextran. These can, in a later stage, be converted into thiol-specific reactive disulfides by reaction with (alkoxycarbonyl)sulfenyl chloride. A dextran-protein conjugate is then easily formed by reaction with a thiol group of a cysteine side chain. The disulfide linkage between dextran and the model tripeptides reduced glutathione and N-Ac-L-Cys-L-Ala-L-Lys remains intact, even after 24 h of incubation at 37 degrees C in blood.

Amino Acid Sequence↗
PubMedDate not supplied

Observer variation in abdominal CT.

Observer performance in radiologic interpretation has traditionally been based upon Receiver Operating Characteristic (ROC) analysis. A statistical method that evaluates the reproducibility or consistency of radiologic interpretation is presented. Since this method is not based upon pathologic verification, it cannot be used to assess accuracy of interpretation and is therefore not a substitute for ROC analysis. Rather, it can either supplement ROC analysis or be of use in situations in which the latter is not feasible or practical.

Humans↗
PubMedDate not supplied

Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

OBJECTIVE: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy, or a combination of exercise and sertraline. METHODS: The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report using the Beck Depression Inventory. Assessments were performed at baseline, after 4 months of treatment, and 6 months after treatment was concluded (ie, after 10 months). RESULTS: After 4 months patients in all three groups exhibited significant improvement; the proportion of remitted participants (ie, those who no longer met diagnostic criteria for MDD and had an HRSD score <8) was comparable across the three treatment conditions. After 10 months, however, remitted subjects in the exercise group had significantly lower relapse rates (p = .01) than subjects in the medication group. Exercising on one's own during the follow-up period was associated with a reduced probability of depression diagnosis at the end of that period (odds ratio = 0.49, p = .0009). CONCLUSIONS: Among individuals with MDD, exercise therapy is feasible and is associated with significant therapeutic benefit, especially if exercise is continued over time.

Antidepressive Agents↗