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S Hercberg

Publications and source records attributed to S Hercberg.

At least 163 records · Page 9Linked to original sources
PubMed1985

[Study of the iron status of a population of pregnant women].

Serum ferritin, haemoglobin, erythrocyte constants, serum iron and the fixation capacity of transferrin were determined in 233 pregnant women consulting a maternity clinic in the Paris area. 1 metropolitan frenchwoman out of 9 and almost half of the immigrants were found to suffer from anaemia at term. A virtual absence of iron reserves (serum ferritin less than microgram/l) was found in 20% of the metropolitan women during the 3rd month of pregnancy, in 60% during the 6th month and in 75% during the 9th month. The figures were 60%, 100% and 90% respectively in the immigrant group. Considering the anaemia-related risks and the eventual repercussions of iron deficiency on a pregnancy, the health of the mother and the foetus, a systematic increase in iron as of the 2nd trimester of pregnancy is recommended.

Adult↗
PubMed1984

The activity of tissue enzymes in iron-deficient rat and man: an overview.

The effects of iron deficiency in rat and/or man on iron-containing enzymes of different tissues is reviewed. Iron deficiency results in a decrease of skeletal muscle iron containing proteins e.g. myoglobin, cytochromes c, a + a3, and alpha-glycerophosphate oxidase. Iron deficiency produces a reduction in the activity of several respiratory enzymes in the mitochondrial fraction of cardiac muscle, particularly: NADH cytochrome c reductase, succinic cytochrome c reductase, succinic dehydrogenase and NADH ferricyanide oxidoreductase. The effects of iron deficiency on brain tissue is emphasized with respect to cytochromes, monoaminoxidase and amino acids metabolism. Host defence to infection (controversial data), decrease in body temperature, alteration of DNA synthesis, collagen and lipid metabolism, liver and gastrointestinal mucous cytochromes activity perturbations are discussed.

Amino Acids↗
PubMed1984

[Dietary iron intake in a population of French women of reproductive age].

Dietary iron intake has been estimated in 337 healthy, menstruating women, of high social conditions by dietary histories. The mean daily iron intake was 11 +/- 0.13 mg, of which 33% was supplied by meat and fish, whereas fruits and vegetables supplied 29%. The mean daily energy intake was 2,088 +/- 27 kcal (8,723 +/- 113 kJ). In 96.5% of the women, iron intake was lower than the Recommended Dietary Allowances (16-18 mg daily). There was a significantly positive correlation between energy intake and iron intake (r = 0.77; p less than 10(-9]. Therefore, the low iron intake may be considered as a consequence of a decrease in the energy intake observed during the last decades in industrialized countries. Iron fortification of one or several foods seems to be advisable to compensate, at least, partly iron intake deficiency.

Adolescent↗
PubMed1984

[Relations between iron levels in mothers and in their newborn infants].

The iron levels were evaluated in 124 pregnant women towards the end of their pregnancies and in their newborn babies in 4 maternity units in Paris and in the surroundings. Two-third of the women studied had total absence of iron reserves (shown by a serum ferritin level less than or equal to 12 micrograms/l). Those who were at the greatest risk of having iron deficiency or anaemia were immigrant, non continental french and multiparous women. The tissue reserves of iron in the newborn are not directly linked to the levels of iron in the mother but are probably linked to the foetal and maternal haemoglobin-synthesis.

Adolescent↗
PubMedDate not supplied

Iodine intakes assessed by urinary iodine concentrations in healthy children aged ten months, two years, and four years.

Urinary iodine excretion was assessed in 642 healthy children aged 10 mo (n = 243), 2 yr (n = 183), and 4 yr (n = 216) living in the Paris area and originating from continental France (60.3%), North Africa (13.8%), the West Indies (9.1%), West Africa (8.3%), Southeast Asia (4.8%), and southern Europe (3.8%). Mild impairment of neurological (reflexes, tone, audiometry) and intellectual development (Brunet-Lézine scale) was assessed in relation to iodine status. Iodine excretions (median values) were 18.4, 11.9, and 10.9 micrograms/100 mL at 10 mo, 2 yr, and 4 yr, respectively, and risk of mild iodine deficiency (5-10 micrograms/100 mL) was 18.1%, 34.8%, and 38.3% for the same age groups. No relationship was found between anthropometry, global development quotient, and iodine status. High hearing thresholds were more commonly associated with lower iodine excretion, suggesting mild hearing defects. In spite of iodine prophylaxis, the risk of mild to moderate iodine deficiency still exists in France and in a number of European countries. Evaluation of neurological sequels of borderline iodine status is a major public health problem in European communities.

Aging↗
PubMedDate not supplied

Interleukin 2 production in iron-deficient children.

The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.

Anemia, Hypochromic↗
PubMedDate not supplied

"The SU.VI.MAX Study": a primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers. SUpplementation on VItamines et Minéraux AntioXydants.

The "SUpplementation en VItamines et Minéraux AntioXydants" (SU.VI.MAX) Study is a randomized double-blind, placebo-controlled, primary-prevention trial which started in 1994 in France. This epidemiologic study is designed to test the efficacy of a daily supplementation with antioxidant vitamins (vitamin C, 120 mg, vitamin E, 30 mg, and beta-carotene, 6 mg) and minerals (selenium, 100 microg, and zinc, 20 mg) at nutritional doses, in reducing the main causes of premature death (cancers and cardiovascular diseases); 12,735 eligible subjects (women aged 35 to 60 years, and men aged 45 to 60 years) were included in 1994 and and will be followed up for 8 years. Participants undergo a yearly visit consisting, every other year, of either biological sampling or clinical examination. They also regularly provide information on health events and dietary intake by filling out computerized questionnaires using the Minitel Telematic Network. After 2 years of supplementation, biochemical indicators of vitamin and trace element status reach reasonable level without reaching concentrations as high as those observed in intervention studies, which tested relatively high doses of antioxidants, and ended up with higher risk of pathology.

Adult↗
PubMedDate not supplied

[Vitamins and aging].

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Age Factors↗