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Biomedical subjects

S Hellman

Publications and source records attributed to S Hellman.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

Prognostic factors in patients with subdiaphragmatic Hodgkin's disease.

Between April 1969 and December 1980, 329 patients with pathologically staged IA-IIB Hodgkin's disease were treated at the Joint Center for Radiation Therapy. Twenty-five (7.6 per cent) of these patients presented with inguinal-femoral or superficial iliac adenopathy and had disease limited to below the diaphragm. In addition 11 patients presented with intra-abdominal masses and Hodgkin's disease was diagnosed on laparotomy. The median age, histologic subtypes, and actuarial relapse free and overall survival of patients with peripheral adenopathy limited to below the diaphragm were similar to patients with supradiaphragmatic Hodgkin's disease. Patients with disease limited to the pelvic or inguinal-femoral nodes were treated with pelvic and para-aortic irradiation alone. Staging laparotomy identified those patients with para-aortic or splenic involvement and these patients were treated with total nodal irradiation or combined modality treatment. The small group of patients who presented with intra-abdominal disease without peripheral adenopathy was older, had a predominance of lymphocyte depleted histology, and had a worse prognosis than the other patients described.

Actuarial Analysis↗
PubMedDate not supplied

Early breast cancer: significance and effectiveness of local control by conservative surgery and primary radiation therapy.

The significance of local-regional control in patients with early breast cancer is examined in the light of data from recent studies. Information from prospectively randomized studies assessing early detection, surgical and radiation therapy procedures, and adjuvant systemic therapies, supports the importance of achieving optimal local-regional control. In most patients effective local control can be achieved without removal of the breast. Wide excision of the primary tumor, axillary dissection and radiation therapy, result in good local control and survival rates that are equal to those achieved with radical mastectomy. The historical development of alternatives to mastectomy is described. Recent data from retrospective and prospective randomized studies evaluating the effectiveness of limited surgery and primary radiotherapy are reviewed and analyzed.

Breast Neoplasms↗