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Biomedical subjects

S Heim

Publications and source records attributed to S Heim.

346 records · Page 20Linked to original sources
PubMedDate not supplied

Population explosion: the making of a vision.

The authors of the publication "Population Explosion: the Making of a Vision" state: "During our research in the US our goal was to find out how the problem of 'overpopulation' had become, or better said, been made universal following the Second World War. How was it possible that the view become consensus that population size is determined by state or internationally controlled economic variables and that the future of this planet depended upon an optimal control? Finally, how did contraception or the decision how many children a women bears become a political question? Better said, how did they become part of US foreign policy? Through our research we became acquainted with the development of the contraception of 'overpopulation,' from myth to scientific fact, from the perspective of those who were responsible for this evolution." This publication also includes the authors' conclusions of their study and 32 documents consulted by them. It is an interesting vision on how consensus is created.

Conservation of Natural Resources↗
PubMedDate not supplied

CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression.

The Coding Region Determinant-Binding Protein (CRD-BP) is an RRM and KH-domain-containing protein that recognizes specifically at least three RNAs. It binds to one of the two c-myc mRNA instability elements, to the 5'Un Translated Region (UTR) of the leader 3 IGF-II mRNA and to the oncofetal H19 RNA. CRD-BP has been assigned a role in stabilizing c-myc mRNA by preventing its endonucleolytic cleavage and in repressing the translation of the leader 3 IGF-II mRNA, the major embryonic species of this message. CRD-BP is normally expressed only in fetal tissues. However, its expression is detected in primary tumors and transformed cell lines of different origins. The vast majority of colon (80%) and breast (60%) tumors and sarcomas (73%) express CRD-BP whereas in other tumor types, for example prostate carcinomas, its expression is rare. CRD-BP expression has also been detected in benign tumors such as breast fibroadenomas, meningiomas and other benign mesenchymal tumors, implying a role for this gene in abnormal cell proliferation. In breast carcinomas, CRD-BP expression and or gene copy number gains in the region encompassing the c-myc locus were detected in approximately 75% of tumors, implying that the deregulated expression of c-myc may be more widespread than previously believed. Infiltrated lymph nodes, corresponding to CRD-BP-positive primary tumors, were also found positive indicating that monitoring for CRD-BP could prove useful for the detection and monitoring of disseminated disease.

Animals↗