Biomedical subjects

S Hayasaka

Publications and source records attributed to S Hayasaka.

350 records · Page 20Linked to original sources

PubMedDate not supplied

Methicillin-resistant staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas.

We evaluated the existence of methicillin (DMPPC)-resistant staphylococci and ofloxacin (OFLX)-resistant bacteria among preoperative patients at an eye clinic. Bacterial growth was studied in 194 conjunctival specimens of 125 preoperative patients without signs of ocular infection. Specimens were evaluated for growth of bacteria on Drigalski's plates, blood agar plates, or chocolate agar plates for 2 days at 37 degrees C. Susceptibilities of the strain to DMPPX, OFLX, minocycline (MINO), gentamicin (GM), erythromycin (EM), cefmenoxime (CMX), chloramphenicol (CP), and sulbenicillin (SBPC) were determined by the disk diffusion method. When DMPPC-resistant Staphylococcus aureus (MRSA) or DMPPC-resistant coagulase- negative staphylococci (MRCNS) were isolated, the susceptibility of the isolated strains to vancomycin (VCM) was additionally examined by the disk diffusion method. Of the 125 preoperative patients (194 eyes), 109 patients (159 eyes) had positive bacterial growth. Methicillin-resistant Staphylococcus aureus (MRSA) were positive in 1 patient. Methicillin-resistant coagulase-negative staphylococci (MRCNS) were positive in another patient. Two eyes with MRSA or MRCNS growth were treated with topical instillation of VCM, which was more sensitive than MINO and GM. They underwent the planned surgery after two subsequent tests showing negative growth. Of 120 isolated coagulase-negative staphylococci (CNS) 8 (6.7%) were resistant to OFLX. OFLX-resistant CNS were sensitive to MINO, CMX, and CP, but also resistant to SBPC. Of 114 isolated aerobic gram-positive rods (GPR), 55 (48.2%) were resistant to OFLX. OFLX-resistant aerobic GPR were sensitive to MINO, CMX, SBPC, and DMPPC. The 157 eyes with positive bacterial growth other than MRSA were treated with topical instillation of sensitive antibiotics. The present findings indicate that DMPPC-resistant staphylococci and OFLX-resistant bacteria exist in conjunctivas without signs of infection.

Adult↗

PubMedDate not supplied

Bilateral congenital macular coloboma in a boy with Down syndrome.

PURPOSE: To describe macular coloboma in Down syndrome. METHODS: A 12-year-old boy with Down syndrome underwent ophthalmologic examination. RESULTS: The patient had a circumscribed, round defect about 1 disc diameter, with bared sclera at the base and pigment clump at the macula in both fundi. His poor visual acuity was unchanged since childhood. The results of serum IgG and IgM titers for Toxoplasma gondii were negative. CONCLUSIONS: Congenital macular coloboma associated with Down syndrome, as demonstrated in our patient, may not have occurred by chance.

Child↗

PubMedDate not supplied

Ocular manifestations in patients with microscopic polyangiitis.

PURPOSE: To describe ocular manifestations in patients with microscopic polyangiitis. METHODS: Two patients with microscopic polyangiitis complained of ocular symptoms and underwent ophthalmologic examinations. RESULTS: An 83-year-old woman (Case 1) was diagnosed with microscopic polyangiitis, according to the general clinical findings and the presence of perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA). She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. The patient was treated with oral prednisolone and subconjunctival betamethasone. The hypopyon iridocyclitis and retinal cotton-wool spots responded. A 79-year-old man (Case 2) had bilateral scleritis. The diagnosis of microscopic polyangiitis was made based on general clinical findings and the presence of P-ANCA. Scleritis was reduced after corticosteroid treatment. CONCLUSIONS: Ophthalmologists should be aware that hypopyon iridocyclitis, cotton-wool spot, and scleritis could occur in patients with microscopic polyangiitis.

Aged↗

PubMedDate not supplied

Epibulbar complex choristoma involving the bulbar conjunctiva and cornea.

A male infant was born with a fleshy mass between the temporal bulbar conjunctiva and cornea in the right eye. Four weeks after birth the patient underwent excision of the epibulbar tumor and a lamellar keratoplasty. Histopathologic examination of the excised tumor revealed cartilage, lobules of lacrimal gland, and adipose tissue, indicating an epibulbar complex choristoma. Although the graft remained almost completely transparent, right amblyopia ensued. Epibulbar complex choristoma involving the conjunctiva and cornea is a rare condition.

Adipose Tissue↗

PubMedDate not supplied

Congenital nasolacrimal duct obstruction in Japanese infants: its incidence and treatment with massage.

We examined the patency of 670 nasolacrimal ducts in 335 newborn infants--42 patients (62 ducts) had obstructions; the involvement was unilateral in 22 and bilateral in 20. No sexual predilection was noted. All affected patients were treated with hydrostatic massage at the area of the lacrimal sac. About two-thirds of the ducts became patent by 2 months after birth, while the remainder became patent by 9 months. Only one patient who had acute dacryocystitis at age 5 months required a probing of the duct and a regimen of systemic antibiotics to achieve good results.

Female↗

PubMedDate not supplied

Differential diagnosis of diffuse choroidal atrophies. Diffuse choriocapillaris atrophy, choroideremia, and gyrate atrophy of the choroid and retina.

Three young children showed a similar fundus appearance of sharply defined, yellowish-white, patchy or geographic atrophy of the retina and choroid and visible large choroidal vessels in almost the entire fundus. Fluorescein angiography disclosed atrophy of the retinal pigment epithelium and loss of choriocapillaris. Their visual functions and electrophysiologic findings were also similar. Family A was diagnosed as having diffuse choriocapillaris atrophy with autosomal dominant inheritance; family B, choroideremia with X-linked recessive heredity; and family C, gyrate atrophy of the choroid and retina with hyperornithinemia and autosomal recessive transmission. It became evident that diffuse choriocapillaris atrophy, choroideremia, and gyrate atrophy sometimes show a similar fundus appearance. Fluorescein angiography, serum ornithine levels, and family history were particularly helpful to differentiate these diffuse choroidal atrophies.

Adolescent↗

PubMedDate not supplied

High myopia, retinal dystrophy, and mental retardation in siblings.

A 15-year-old girl and her 13-year-old brother had high myopia, mottled retinas with nonrecordable electroretinographic responses OU, and mental retardation. Both siblings had normal pupillary reactions to light, normal levels of serum amino acids, no nystagmus, no obesity, and no polydactyly. A consanguineous marriage of the patients' parents was found. We believe that the association of high myopia, retinal dystrophy, and mental retardation noted in these siblings may be uncommon.

Adolescent↗

PubMedDate not supplied

Viscoelastic substance in the anterior chamber elevates intraocular pressure.

An 85-year-old man underwent an extracapsular cataract extraction OD with posterior chamber intraocular lens implantation. Sodium hyaluronate (0.3 mL) was used during the procedure, and approximately 1.0 mL of the solution, including the sodium hyaluronate, was aspirated before wound closure. The next day, the intraocular pressure OD was elevated to 60 mmHg, and it remained high despite medication. Three days later, the intraocular pressure was still high, a paracentesis was done, and viscous solution was obtained. After the paracentesis, the intraocular pressure OD normalized.

Aged↗