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Biomedical subjects

S Hayasaka

Publications and source records attributed to S Hayasaka.

At least 271 records · Page 15Linked to original sources
PubMed1983

Central regional total choroidal vascular atrophy in Japanese patient.

We examined an infant whose rare fundus changes were similar to those seen in the early stage of gyrate atrophy of the choroid and retina, or in Aicardi's syndrome. The slightly larger than normal and whitish optic disk, mottled posterior pole of the retina and several atrophic patches around the optic disk were found ophthalmoscopically. These lesions were bilaterally symmetric. Hyperornithinemia was not noted. A CT scan of the brain was normal, and agenesis of the corpus callosum was not found. Convulsions and spasms did not occur. To our knowledge, this is the first reported case of central regional total choroidal vascular atrophy in Japan.

Atrophy↗
PubMed1983

Partial purification of cathepsin B in the bovine ciliary body and iris.

Cathepsin B in the bovine ciliary body and iris was studied biochemically using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate. The enzyme was purified to 210-fold from the autolyzed extract. The partially purified enzyme had a pH optimum at 6.0 and a molecular weight of 27,000. The apparent Km value for the substrate was 1.6 mM. The enzyme was activated by disodium ethylenediamine tetraacetate, cysteine, and dithiothreitol. The enzyme activity was inhibited strongly by leupeptin and partially by hyaluronate and chondroitin sulfate A.

Animals↗
PubMed1982

Atypical gyrate atrophy of the choroid and retina associated with iminoglycinuria.

A 44-year-old woman had a fundus appearance similar to that of gyrate atrophy, a macular lesion, and excessive urinary excretion of proline, hydroxyproline, and glycine. The patient also had abnormal ciliary processes and patchy atrophy of the irides. To our knowledge, this is the first reported case of ocular manifestations associated with iminoglycinuria.

Adult↗
PubMed1982

Systemic corticosteroid treatment in Vogt-Koyanagi-Harada disease.

Twenty patients with Vogt-Koyanagi-Harada disease who had been given systemic corticosteroids were retrospectively analyzed. Sixteen patients were successfully treated with systemic corticosteroids without recurrence of uveitis. Since the advent of corticosteroid treatment, there have been fewer ocular complications as well as extraocular sings and symptoms in most cases. Recurrence of the inflammation, however, occurred in four cases. Drip infusion of 200 mg prednisolone daily, widely employed for the treatment, did not always have good results. It is suggested that the dosage of corticosteroid should be adjusted according to the severity of uveomeningitis. Oral administration of corticosteroid (less than 100 mg prednisolone daily) may be enough for suppression of the inflammation in the Harada type, while a drip infusion of the massive dosage (more than 200 mg prednisolone daily) with gradual tapering off is possible requisite in the Vogt-Koyanagi type.

Adolescent↗
PubMed1982

Lysosomal hyaluronidase in the subretinal fluid of patients with rhegmatogenous retinal detachments.

A biochemical analysis of 66 samples of subretinal fluid from patients with primary rhegmatogenous retinal detachment showed that 46 contained hyaluronic acid. Seventeen samples that did not contain hyaluronic acid disclosed hyaluronidase activity. Hyaluronidase activity in the subretinal fluid increased with the duration of the detachment but there was no correlation between enzyme activity and the age of the patient or the extent of the retinal detachment.

Adult↗
PubMed1982

A scanning electron microscopic study of nylon degradation by ocular tissue extracts.

A scanning electron microscopic study showed that the surface of the nylon used for corneoscleral wound closure was smooth, while the nylon suture thread used to fix the intraocular lens against the iris showed cracks and roughness on its surface. The surface of the nylon thread was also roughened after treatment with bovine iris-ciliary body extracts. The nylon-degrading factor in the extract was nondialyzable, heat-labile, active at acidic pH, and inhibited in part by leupeptin, suggesting that lysosomal enzymes may be a factor in this phenomenon. Of the bovine ocular tissues, ciliary body extract degraded the surface of the nylon thread most significantly. The nylon surface was moderately digested by the retinal pigment epithelial extract, and slightly eroded by the extracts from the iris, sensory retina, and choroid. Corneal and lenticular extracts did not affect the nylon surface. Nylon suture thread may be hydrolyzed by lysosomal enzymes and should be considered a late-degrading suture.

Animals↗
PubMed1982

Development of ornithine ketoacid aminotransferase in rabbit ocular tissues and liver.

Ornithine ketoacid aminotransferase in ocular tissues and liver was examined biochemically during the development of the rabbit. Developmental differences of specific enzyme activities were found between the ocular tissues and liver. The retina and choroid showed a relatively low activity after birth and an increased activity at 2.5 weeks, which remained high thereafter. The ciliary body and iris also showed a relatively low activity at birth and a rapid increase at 1 week, which remained so for about 14 weeks before a gradual decrease occurred. The enzyme in the liver exhibited a high activity at birth, which fell 1 week later. This was followed by a subsequent increase in enzyme activity that began at 7.5 weeks after birth. Enzyme activity peaked at 10 weeks, with a gradual diminution thereafter.

Aging↗