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Biomedical subjects

S Havelka

Publications and source records attributed to S Havelka.

115 records · Page 7Linked to original sources
PubMedDate not supplied

[Experimental arthrosis caused by chemical cartilage damage].

In experiments on rabbits the authors studied the dynamics of cartilage degeneration and subsequent pseudorepair processes following what was doubledose chemical damage to articular cartilage. In addition to the classical histological methods they used the histochemical demonstration of hydrolase and dehydrogenase which are of prime importance to cartilage. The intraarticular instillation of sodium iodacetate caused major and irreversible damage to the whole cartilaginous layer. Subsequent pseudorepair proceeded on the one hand from the cells of the peripheral synovial membrane and on the other to a lesser extent from the fibroblasts of the subchondral bone marrow. The most important enzymes depicting these processes can be regarded as AP and LDH. From the viewpoint of accessibility of dystrophic articular cartilage to repair cells one must distinguish the central part of the joint from its periphery. In the latter area of the cartilage it were mainly synovial cells which took part in repair and pseudorepair takes place considerably more actively here than in the central parts of the joint.

Animals↗
PubMedDate not supplied

[Changes of various organs in joint diseases].

In a review of organic changes of rheumatic diseases the more important changes of skeletal musculature, gastro-intestinal apparatus, kidneys, blood vessels and eyes are discussed. The paper is based upon investigations, publications and post-graduate activities of the Rheumatism Research Institute of Prague.

Acid Phosphatase↗
PubMedDate not supplied

[Lymphocyte nucleoli in the peripheral blood and knee joint effusions in patients with rheumatoid arthritis].

Since the activation of nucleoli in lymphocytes reflected by the presence of nucleoli with more or less distinct nucleolonemata (compact nucleoli in the light microscope) in these cells is considered as a marker of the autoimmune disease development, nucleoli of lymphocytes were investigated in the peripheral blood (22 investigations) and knee joint fluid (52 investigations) of juvenile and adult persons with rheumatoid arthritis. The results clearly indicate that the investigated joint exudates possessed a higher number of "active" lymphocytes (lymphocytes with compact nucleoli) in comparison with the peripheral blood. This observation can be interpreted as an accumulation of stimulated immunocompetent cells in the target organ.

Arthritis, Juvenile↗