Search PubMed⌕ Search

Biomedical subjects

S Hashimoto

Publications and source records attributed to S Hashimoto.

At least 1,009 records · Page 56Linked to original sources
PubMed1988

[The radiosensitivities of human neuroblastoma in vitro--a comparison of three cell lines].

The radiation response of three human neuroblastoma cell lines (GOTO, NB1M, and SINCG) has been studied in vitro, using single cells both in the exponentially proliferative and the plateau phases. The endpoint used was clonogenic cell survivals. Cell survival curves, obtained from all cell lines, were characterized by small D0 values (0.4-0.55 Gy). However, only the GOTO cells showed the lack of a shoulder in the survival curve, whereas the other cell lines, especially the SJNCG, showed a broad sized shoulder. Delayed assay experiments with SJNCG cells showed larger repairs of potentially lethal damage, both in the exponentially proliferative and plateau phases, in contrast to GOTO cells. Further, the cell capacity for a split dose recovery was greater in SJNCG cells than in the GOTO cells. It has been said that hyperfractionation radiotherapy might be a better treatment for a neuroblastoma than the conventional therapy, however, we would suggest that a modification of the radiotherapy schedule ought to depend on the type of cells, because there are cells which show broad shoulder curves and a strong capacity for repair.

Cell Division↗
PubMed1988

[Left ventricular systolic blood flow dynamics and left ventricular wall motion abnormalities in atrial fibrillation].

We have already reported that, in atrial fibrillation (Af) "back flow" in the left ventricular (LV) central or apical area may occur in the cardiac cycle with a short preceding R-R interval, especially in cases with impaired LV pump function. This abnormal flow was considered to be caused by LV asynchrony. Analysis of LV wall motion abnormalities, however, is a less established procedure. The purpose of the present study was to clarify the relationship between LV blood flow dynamics and LV wall motion using pulsed Doppler echocardiography and left ventriculography. The results were as follows: 1. In seven of 15 cases "back flow" was observed in the LV central or apical area. 2. On left ventriculography in the seven cases, the apical area showed a backward movement in a longitudinal direction in the cardiac cycle with a short preceding R-R interval. 3. The % shortening of the long-axis dimension was significantly decreased in the seven cases with back flow, and three of them had negative values. 4. Ejection fractions (EF) of both the apical and basal halves were significantly decreased in cases with back flow, and the difference in the ejection rate of the apical and basal halves tended to decrease in cases with back flow. 5. LVEF was also significantly decreased in the cases with back flow. These results indicate that left ventricular "back flow" observed in Af is caused by the LV asynchrony due to localized wall motion abnormalities in the apical area.

Atrial Fibrillation↗
PubMed1988

[Left ventricular wall thickness in hypertrophic cardiomyopathy: comparisons of measurements by magnetic resonance imaging, cineangiography, and echocardiography].

To evaluate the usefulness of magnetic resonance imaging (MRI) in measuring regional wall thickness of the left ventricle, 11 patients with hypertrophic cardiomyopathy (HCM) were imaged. The measurements were compared with those obtained by two-dimensional echocardiography (2D-echo) and cineangiography. Regional wall thickness was ascertained at six locations including the base, middle, and apex of the interventricular septum (IVS) and left ventricular posterior wall (LVPW) from the two selected transverse sections. All of these six locations were also measured for the IVS by biventriculography and for the LVPW by left ventriculography with the left anterior oblique view. Only the base was measured for both the IVS and LVPW using 2D-echo because of the difficulty in obtaining good images for the middle and apex of the left ventricle. The measurements by MRI correlated well with those obtained by 2D-echo and cineangiography in the majority of locations. At the base, where the wall thickness was measured by the three methods, the measurements of the IVS correlated well each other (r = 0.63 to 0.81). However, a good correlation was obtained only between 2D-echo and MRI for the LVPW r = 0.75. The correlation between MRI and cineangiography was generally good for the IVS at any levels (r = 0.76 to 0.87), but not for the LVPW. This was partially due to the narrow range of data for the LVPW as well as to the difficulty in determining the epicardial border in left ventriculograms. In conclusion, regional wall thickness can be correctly measured by MRI in any locations of the left ventricle even at the apex, where measurement is difficult by other methods.

Adolescent↗
PubMed1988

[Long-term follow-up after tumorectomy and irradiation for breast cancer].

From 1968 to 1976, 31 patients underwent breast conservation surgery (tumorectomy) and irradiation. A review of the available pathologic slides has revealed that 11 of that number had definite breast cancer. Of these 11 patients, three experienced a relapse, one with local recurrence only, and two with distant metastasis, though one of these two also had a local recurrence. The patient manifesting a local recurrence only was salvaged by a mastectomy, while the other two with distant metastases have died. Survival and disease-free survival in these 11 patients were at least equal to the results of other Japanese patients of the same ages and stages who had undergone a halsted operation during the same period. As for the other 20 patients, either their pathologic slides were not available, or their diagnosis was equivocal or benign. None suffered a relapse. Cosmetic results were excellent in most patients, and there were no second malignancies in the treatment volume.

Adult↗
PubMed1988

Iodine-131 therapy for parotid oncocytoma.

We present a rare case of a patient with coexisting parotid oncocytoma and chronic thyroiditis who received two therapeutic doses of [131I]iodide for a recurrent oncocytoma (oxyphilic granular cell adenoma), resulting in a definite reduction in tumor volume. We suggest that radioiodine therapy for a recurrent oncocytoma is an effective form of tumor therapy.

Adenoma↗