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Biomedical subjects

S Harrison

Publications and source records attributed to S Harrison.

At least 163 records · Page 9Linked to original sources
PubMed1980

Facts of life about industrial relations training.

It is likely that the role of all line managers will come to include an element of industrial relations, write Steve Harrison and Stuart Dimmock. The emphasis on conflict resolution rather than how it is generated means that the line manager's role will become overwhelmingly important.

Administrative Personnel↗
PubMed1979

Political skills and the science of diplomacy.

Present NHS management structure involves relationships which are based more on political processes than authority. In the first of a two-part article Steve Harrison and Jack Hallas look at management as a political process and argue that politics are about redistribution of resources and cannot be taken out of health care management.

Administrative Personnel↗
PubMed1979

Pollen-stigma interactions: Identification and characterization of surface components with recognition potential.

Male-female recognition in flowering plants is initiated by mutual contact of pollen and stigma surface components. Analysis of the surface macromolecules of both stigma and pollen of Gladiolus gandavensis revealed a complex mixture of proteins, glycoproteins, and glycolipids. The carbohydrate-containing components amounted to 6% in pollen and 23% in stigma and contained the monosaccharides galactose, arabinose, glucose, mannose, and rhamnose. All the mannose of both preparations was associated with a fraction that bound to concanavalin A. The stigma surface contained an arabinogalactan or arabinogalactan protein as a major component. This component has been isolated by affinity chromatography on tridacnin-Sepharose and shown to be similar in composition to a style canal component isolated in the same way. The capacity of the stigma surface preparations to bind nonspecifically to macromolecules from pollen and other sources has been demonstrated in vivo and in vitro. Specific binding of concanavalin A to the stigma surface decreases the adhesive capacity for pollen protein. The arabinogalactan of the stigma surface may act as an adhesive base. The pollen and stigma surfaces apparently complement one another to provide all the components of an ideal adhesive.

Journal Article↗
PubMed1977

Use of intramedullary polypropylene peg for joint stabilization in leprosy.

Joint arthrodesis is indicated when motion in a joint cannot be restored, and that joint requires stabilization in an optimal functional position. The Harrision Intramedullary peg has been used to advantage for this purpose in hand reconstruction in leprosy in a renal developing area. It is a method to be considered for selected cases requiring joint stabilization to improve total hand function.

Arthrodesis↗
PubMed1976

Structure and assembly of the capsid of bacteriophage P22.

Identification of the genes and proteins involved in phage P22 formation has permitted a detailed analysis of particle assembly, revealing some unexpected aspects. The polymerization of the major coat protein (gene 5 product) into an organized capsid is directed by a scaffolding protein (gene 8 product) which is absent from mature phage. The resulting capsid structure (prohead) is the precursor for DNA encapsidation. All of the scaffolding protein exits from the prohead in association with DNA packaging. These molecules then recycle, directing further rounds of prohead assembly. The structure of the prohead has been studied by electron microscopy of thin sections of phage infected cells, and by low angle X-ray scattering of concentrated particles. The results show that the prohead is a double shell structure, or a ball within a shell. The inner ball or shell is composed of the scaffolding protein while the outer shell is composed of coat protein. The conversion from prohead to mature capsid is associated with an expansion of the coat protein shell. It is possible that the scaffolding protein molecules exit through the capsid lattice. When DNA encapsidation within infected cells is blocked by mutation, scaffolding protein is trapped in proheads and cannot recycle. Under these conditions, the rate of synthesis of gp8 increases, so that normal proheads continue to form. These results suggest that free scaffolding protein negatively regulates its own further synthesis, providing a coupling between protein synthesis and protein assembly.

Capsid↗
PubMed1976

Cell recognition in plants: Determinants of the stigma surface and their pollen interactions.

The interaction between compatible pollen grains and the female stigma of Gladiolus gandavensis has been used as a model system for investigation of cell recognition in plants. The molecular architecture of the receptive stigma surface has been investigated, and determinants binding to both concanavalin A and beta-glucosyl artificial carbohydrate antigen, as well as esterase activity, have been characterized, and conditions for their isolation have been established. The stigma surface, before and after modification, was found to bind (125)I-labeled proteins nonspecifically. Pollen tube penetration of the papillar cuticle is prevented when the receptor sites for concanavalin A are occupied. The concanavalin-A-binding determinants of the stigma surface have been fractionated to reveal several glycoproteins in the molecular weight range 43,000-93,000 and a group of glycolipids of molecular weight approximately 22,000. These results are interpreted in terms of two major recognition events regulating pollination.

Journal Article↗