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Biomedical subjects

S Han

Publications and source records attributed to S Han.

299 records · Page 17Linked to original sources
PubMed1977

Gastric diverticula following subtotal gastrectomy.

Four cases of gastric diverticula following subtotal gastrectomy are described. This type of diverticula associated with partial gastrectomy are probably true, acquired, pulsion diverticula. In two of our patients the diverticula were associated with significant prolapse of gastric mucosa causing obstruction at the anastomosis.

Adult↗
PubMedDate not supplied

Toxicity of organic chemicals to fathead minnow: a united quantitative structure-activity relationship model and its application.

A general and practical relation has been established between structure and activity of organic chemicals based on target theory. This relation was tested by examining the correlations between the acute toxicity and the physicochemical properties for fathead minnow, which showed that this relation can explain the observed toxicity data and phenomena successfully. The equations are then used to estimated the acute toxicity data of organic chemicals, and the predicted values are close to observed values.

Animals↗
PubMedDate not supplied

Expression of Mad1 protein inhibits proliferation of cancer cells and inversely correlated with Myc protein expression in primary gastric cancer.

We performed immunohistochemical assay for Mad1 and Myc protein in 76 gastric cancer tissues. Cancers with reduced Mad1 expression had high proliferative index (S and G2/M-phase) and there was inverse correlation between Mad1 and Myc expression in the same cancer cells. There was no significant correlation between expression of Mad1 and cell differentiation or extent of the disease. There was a trend that reduced expression of Mad1 was associated with poor survival of the patients. Mad1 may influence biologic behavior of cancer cell by inhibiting transcriptional activity of Myc and reduced levels of Mad1 expression seem to be associated with carcinogenesis in human gastric cancer.

Adult↗
PubMedDate not supplied

[Fatty acid metabolic and perfusion abnormalities in hypertrophied myocardium assessed by dual tracer tomography using thallium-201 and iodine-123-beta-methylpentadecanoic acid].

Fatty acid metabolic and perfusion abnormalities associated with cardiac hypertrophy were investigated using dual tracer tomography with thallium and a cardiac metabolic tracer, 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (BMIPP), in eight patients with hypertrophic cardiomyopathy (HCM) and in three with hypertension (HT). Thallium and BMIPP uptakes were scored and analyzed in 143 segments (13/heart) by comparison with the left ventricular wall thickness measured by two-dimensional echocardiography. Complete agreement of both scores in HT patients was significantly higher than that in HCM patients (64% vs 24%, p < 0.001), while a lower BMIPP uptake compared to that of thallium (mismatching) was observed more frequently in HCM than in HT patients (65% vs 31%, p < 0.001). The wall thickness significantly (p < 0.005) correlated with BMIPP uptake score. HCM patients showed a low BMIPP uptake in 22 hypertrophic segments (59%) and 15 non-hypertrophic segments (41%), and reduced BMIPP uptake in 29% hypertrophic segments, while HT patients showed just five segments with decreased BMIPP uptake of which 4 were non-hypertrophic and only one hypertrophic. The left ventricular ejection fraction assessed by radionuclide ventriculography was normal and no regional wall motion abnormality was detected in any patient by echocardiographic and scintigraphic studies. Metabolic abnormalities detected by the iodine-123-beta-methyl fatty acid analog in hypertrophic cardiomyopathy may be independent of thallium myocardial perfusion, regional wall motion, or the magnitude of cardiac hypertrophy, suggesting that fatty acid imaging may be useful in investigating the pathogenesis and subclinical abnormality of hypertrophic cardiomyopathy, and differentiation from secondary, induced cardiac hypertrophy.

Adult↗
PubMedDate not supplied

Isolation and identification of chicken infectious anemia virus in China.

A chicken infectious anemia virus (CIAV) isolate was obtained from broiler flocks aged 25-40 days with anemia and poor performance and was designated SR43. The CIAV isolate was resistant to treatment with chloroform and induced thymus atrophy, bone marrow aplasia, and low hematocrit values when inoculated into 1-day-old, susceptible, specific-pathogen-free chicks. CIAV-specific antigens could be demonstrated in SR43-infected MDCC-MSB-1 cells, a cell line derived from a Marek's disease lymphoma, with the use of a monoclonal antibody specific for CIAV. CIAV DNA in infected MDCC-MSB-1 cell cultures was detected by using a polymerase chain reaction assay. These findings demonstrate that CIAV is present in China.

Animals↗