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Biomedical subjects

S Hakusui

Publications and source records attributed to S Hakusui.

24 records · Page 2Linked to original sources
PubMed1990

[A microneurographic analysis of minor reflex sympathetic dystrophy with increased skin sympathetic activity--report of a case].

A 48-year-old man developed swelling, redness, and allodynia in his left palm. Routine physical and neurological examinations revealed no abnormal findings except for left palmar hyperhidrosis. A clinical diagnosis of minor reflex sympathetic dystrophy with causalgia was made. Skin sympathetic activity (SSA), dominating palm sweating and skin vasoconstriction, and discharges of single afferent fiber from the rapidly adapting-type I (RA-I) unit were recorded microneurography from the median nerve at the cubital fossa. SSA obtained from the affected side was significantly increased compared with that from the normal (right) side. The receptive field of RA-I unit in this case was larger than those of normal controls. Enlargement of the receptive field might suggest presence of collateral sprouting in the injured nerve fibers. Allodynia in the left palm was suspected to be resulted from misdirect sprouting between A alpha . beta to A delta . C fibers. Excessive sympathetic out flow to the skin is considered to be the cause of palmar hyperhidrosis, swelling with redness, and lowered pain threshold, since pain threshold is under regulation of SSA. It is concluded that these sensory and autonomic symptoms were resulted from increased sympathetic out flow to the skin and collateral sproutings in the peripheral nerve fibers.

Humans↗
PubMed1990

[Vasopressin effect and pathophysiological analysis on postprandial hypotension].

In order to clarify the effect of arginine vasopressin (AVP) on postprandial hypotension (PPH) in patients with multiple system atrophy, a loading test of 75 g glucose in 225 ml water was performed during infusion of AVP (0.3 U/min). AVP (0.3 U/min) infusion prior to the loading was significantly effective for PPH in all patients: PPH following to oral intake of glucose was completely prevented. We conclude that infusion of AVP maintained circulating systemic blood volumes by reduced portal venous flow (after a reduction of portal venous inflow) as a result of vasoconstrictive effect of AVP on the splanchnic vessels in patients with PPH.

Adult↗
PubMed1989

[Bilateral abductor vocal cord paralysis (Gerhardt syndrome) in the Shy-Drager syndrome].

Ten consecutive patients with a progressive pan-autonomic failure of the Shy-Drager syndrome were investigated. Movement disorders of the vocal cords were examined with a fiber-optic laryngoscope as well as a video-recorder. Moderate to severe vocal cord paralysis was present in five of ten patients. The vocal cords were almost immobile during inspiration, while there was no limitation of the adduction during phonation. In two cases, grade of vocal cord paralysis was asymmetric. One patient developed peculiar twisting-like dystonic movements of the vocal cord. Polygraphic studies revealed that SaO2 was lowered in spite of tachypnea during sleep. In two cases, the expiratory flow volume curve in effort-dependent portion near TLC showed a plateau and the inspiratory part of the curve also showed a plateau indicating constant flow. These functional disorders suggest an upper airway obstruction probably due to the vocal cord dysfunction. There was no vocal cord paralysis in two patients who had neither snore nor stridor. Development of a severe vocal cord dysfunction usually manifested itself clinically as stridor, snore or respiratory failure requiring tracheostomy. There was little information on the pathology of the vagal nerves and nuclei supplying motor control to the laryngeal muscles. The mechanism of the selective involvement of abductor muscle (posterior muscle) of the vocal cord (Gerhardt syndrome) remains unsolved. Vocal cord paralysis should be looked for since it can result in respiratory failure leading to death.

Adult↗
PubMedDate not supplied

An autopsied case of primary epipharyngeal rhabdomyosarcoma presenting Garcin syndrome.

A 61-year-old housewife had complained of unilateral facial pain and had been treated as prolonged trigeminal neuralgia by a dentist. When she came to our clinic, the III-X cranial nerves of the right side were involved. A base view of the skull indicated destructive lesions of the right side middle cranial fossa, and a diagnosis of Garcin syndrome was made. Neurosurgical operation, X-ray radiation and chemotherapy improved to some extent the neurological condition temporarily. Postmortem examination showed an epipharyngeal rhabdomyosarcoma occupying the maxillary sinus, and extradural space of the cranial base on the right side.

Cranial Nerve Diseases↗
PubMedDate not supplied

Primary erythromelalgia: the role of skin sympathetic nerve activity.

A 54-year-old man complained of burning pain, warm skin and erythema in his extremities. A diagnosis of primary erythromelalgia was made. Microneurography was used to clarify the role of skin sympathetic nerve activity in the pathophysiology of primary erythromelalgia. The patient showed normal skin sympathetic nerve activity but no vasoconstriction response. Aspirin activated the skin sympathetic nerve activity and improved vasoconstriction producing symptomatic relief. These results suggest that the lack of vasoconstriction following vasoconstrictor activity of the skin sympathetic nerves results in increased skin blood flow and burning pain.

Aspirin↗