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Biomedical subjects

S Haim

Publications and source records attributed to S Haim.

At least 73 records · Page 4Linked to original sources
PubMed1979

The pathogenesis of lesions in Behçet's disease.

Current concepts incriminate a cell-mediated mechanism in the pathogenesis of mucocutaneous lesions of Behçet's disease. However, such a mechanism alone fails to explain various aspects of hyperreactivity response which is a unique feature manifested with lesions similar to those occurring spontaneously in the disease. 19 patients with active Behçet's disease have been investigated for possible mechanisms other than cell mediated which may be involved in the process. Beside cell-mediated mechanisms there were indications that polymorphonuclear leucocytes and mast cells may play part in the process. Further study of these two aspects may open a new approach in the understanding and possibly in the treatment of this disease.

Behcet Syndrome↗
PubMed1978

Cardiac involvement and superior vena caval obstruction in Behçet's disease.

A patient with Behçet's disease developed the rare complications of pericarditis and, two months later, superior vena caval obstruction. The latter complication was investigated by angiography to exclude other causes. As a result of this investigation the caval obstruction was managed conservatively, the symptoms and signs improving spontaneously.

Adult↗
PubMed1978

Dapsone in the treatment of pemphigus vulgaris.

This is a report on two cases with pemphigus vulgaris effectively controlled by dapsone. In one, dapsone was added to the treatment after a failure of combined prednisone and methotrexate therapy to control the disease completely. It is suggested that dapsone may offer a means in an attempt to minimize adverse reactions met with during the long corticosteroid regimen required in pemphigus.

Adult↗
PubMed1978

Cutaneous manifestations associated with aminoaciduria. Report of two cases.

This is a report of 2 cases revealing photosensitivity in association with aminoaciduria. The first is a patient with psoriasis and the second, a patient with Ehlers-Danlos syndrome, mitis type. The display of the above combinations seems peculiar. The psoriatic lesions become confined mainly to the exposed surface and intermingled with those of photodermatitis forming lesions which are a mixture of the two processes. In the case with Ehlers-Danlos, the disease presented rupioid plaque-like erythematous oozing lesions which seem somewhat different from those of the photodermatosis yet known.

Adolescent↗
PubMed1978

Cutaneous tuberculosis and malignancy.

This is a report of three cases of associated tuberculous and neoplastic processes. The first is a case of lymphosarcoma complicated by cutaneous tuberculosis. The remaining two are cases of cutaneous tuberculosis complicated by squamouse cell carcinoma. Due to clinical similarity, the diagnosis of the secondary process in these cases was evoked by its failure to respond to treatment of the primary disease.

Adult↗
PubMed1978

HL-A antigens in Behçet's disease. A family study.

Histocompatibility antigens (HL-A) were studied in a family with Behçet's disease (BD). All who had symptoms or signs of BD had either HL-A B5 or BW35, or both. The increased number of families with BD recently reported supports the suggestion that positive family history may assist the diagnosis of BD.

Adolescent↗
PubMed1978

Histocompatibility antigens in granuloma annulare. Comparative study of the generalized and localized types.

Thirteen patients with localized granuloma annulare and 19 with the generalized form of the disease were typed for HLA antigens. The control group consisted of 70 matched apparently healthy subjects. No significant difference in the frequencies of the 26 tested antigens was revealed between patients with localized granuloma annulare and controls. Patients with the generalized form of the disease showed a highly significant increase in the frequency of HLA-Bw35 as compared with both controls and patients with the localized form of the disorder (P = 0.001 and 0.01 respectively). The results seem suggestive of a possible different pathogenesis of the two forms of the disease.

Adolescent↗
PubMed1978

[Spider bites].

Explore the source record for details and available documents.

Female↗
PubMed1977

Polymorphonuclear leucocyte function in Behçet's disease.

Polymorphonuclear leucocyte function was investigated in 19 patients with active Behçet's disease. Spontaneous free leucocyte migration was found to be significantly reduced, yet after stimulation the leucocyte's chemotactic activity was considerably increase (p less than 0-05) when compared to control leucocytes. Control leucocytes migrated more rapidly when incubated in serum taken from patients with Behçet's disease (p less than 0-005). The enhanced chemotactic activity in Bechçet's disease appears to be due to both serum and intrinsic leucocyte factors. Spontaneous nitroblue tetrazolium reduction was found to be normal, although after stimulation leucocyte nitroblue tetrazolium reduction was lower than in the control group (P less than 0-025), as was leucocyte oxygen utilisation. It is suggested that the hyperreactive cellular inflammatory response that characterises Behçet's disease may be due to increased chemotactic activity and minor alterations in functional metabolic activity of leucocytes.

Adult↗
PubMed1977

Comparative ultrastructural study of mast cells in mastocytoma and mastocytosis.

The ultrastructural aspects of mast cells from skin lesions in 2 patients with mastocytoma were compared to those from lesions in 4 patients with mastocytosis, 3 with cutaneous and 1 with systemic involvement. In mastocytoma, the mast cells accumulated in a large mass. They revealed short cytoplasmic villi and were similar, morphologically, to mast cells of normal skin and gingiva. In the diffuse types of the disease, cutaneous and systemic, the cells were arranged in small groups. In addition to normal mast cells, there were also irregular or bizarre-shaped cells presenting long and twisted cytoplasmic protrusions. In the case with the systemic involvement and in 2 of 3 cases with apparently cutaneous diffuse lesions, the villi of adjacent cells interlaced and showed a tendency to form mast cell aggregates. The pathognomonic value of the above observation seems worthy of further investigations.

Cell Membrane↗
PubMed1977

Condyloma-like lesions possibly caused by Neisseria gonorrhoeae. Report of a case.

A 2-year old girl suffered from continuous pyogenic inflammation in the anogenital region probably enhanced by neurological alterations. In one episode, the inflammatory process presented multiple moist papillomatous growths on the labia majora and along the anal margin which are thought to have been caused by gonococcal infection.

Child, Preschool↗
PubMed1977

The histocompatibility antigens in patients with Behçet's disease.

Twenty-one patients with Behçet's disease were typed for HLA antigens. The controls were 50 subjects randomly chosen from a local population and 24 apparently healthy subjects of the same ethnic groupings as those of the patients. The study revealed significant differences in the frequencies of various antigens in the above three groups, the most obvious of them related to HLA-B5 and HLA-Bw35, HLA-B5 was demonstrated in 71% of the patients as compared with 18% in the local population group and 12.5% in the ethnically related healthy subjects. The incidences of HLA-Bw35 were 66.7%, 32% and 37.5% respectively. In 86% of the patients, at least one of these two antigens was present. It is suggested that besides contributing to the understanding of the disease process, the determining of associated specific antigens may constitute a further diagnostic acid in doubtful cases of Behçet's disease.

Adolescent↗