Meningococcal endophthalmitis and pericarditis.
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Endophthalmitis↗
Biomedical subjects
S Hague
Publications and source records attributed to S Hague.
Children presenting to an ophthalmic casualty department.
A five month prospective survey of all children (0-14 years) attending an ophthalmic accident and emergency department was carried out to determine the disease profile and the primary ophthalmic health care provided. A data base was used to collect and analyse all cases. Seventy three per cent of 475 children attending had non-traumatic ophthalmic diagnoses, less than half being referred from their general practitioners. The remaining children had minor ophthalmic injuries of which less than one quarter were referred from their general practitioners. Four of the minor ophthalmic injuries were suspected of being non-accidental injury. The management of such cases is discussed. The ophthalmologist in an ophthalmic casualty department has an important role in the provision of primary ophthalmic care for children. In the management of minor ophthalmic injuries, the alerting factors for non-accidental injury should be sought, although the apparent incidence is low.
Adolescent↗
The calibre changes of retinal vessels subject to prolonged hyperoxia.
The constriction of retinal vessels occurring in response to breathing 100% oxygen was studied in 10 normal subjects over a period of 30 min. Brachial blood pressure, radial pulse and end tidal CO2 were recorded throughout. The mean arteriolar constriction was 15.3% +/- 4.6 and venous constriction 21.8% +/- 4.3. Time constants (the time for 95% of the maximal response to have occurred) were 2.25 min +/- 0.75 and 2.37 min +/- 0.57 for arterioles and veins respectively. A highly variable late vascular response was recorded. A small proportion of arterial vessels showing a response were nonuniform while a larger proportion of veins showed a significant dilatation.
Adult↗
Ocular quinine toxicity.
A case of ocular quinine toxicity is described which showed the typical acute visual loss and subsequent recovery. Vermiform motion of the pupil was noted 48 hours after overdose. This acute effect has not been reported before. Although acute systemic intoxication may respond to removal of quinine from the gut and circulation, there is no evidence that any treatment affects the visual prognosis. The action of quinine on the retina is unknown. We suggest it may block cholinergic neurotransmission in the inner synaptic layer.
Adult↗
Postural changes in perfusion pressure and retinal arteriolar calibre.
Ophthalmic artery perfusion pressures and retinal arteriolar calibres were studied in 10 human subjects when sitting, standing, and lying. Differing responses in perfusion pressure were found; autoregulatory responses were found in 13 of the 18 significant calibre changes on moving from sitting to standing and 13 of 22 significant calibre changes on moving from standing to lying. The remaining significant calibre changes were non-autoregulatory, the arterioles dilating with perfusion pressure increase and constricting with decrease.
Adult↗
Morphological changes in the human corneal epithelium associated with surgical corneal clouding.
Light microscopy and electron microscopy were used to define morphological changes occurring in human corneal epithelium during surgery. No correlation was established between preoperative medication or peroperative fluids and corneal epithelial clouding. It is suggested that the changes we observed in relation to epithelial clouding were the direct result of disturbance to endothelial pump functions.
Cell Nucleus↗