Early experience of renal transplantation in hepatitis C patients.
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Biomedical subjects
Publications and source records attributed to S Hafiz.
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Trauma and non-traumatic insults can cause muscle damage to such an extent that serious sequelae to other organs may result. Myoglobinuria and subsequent acute renal failure (ARF) is a well known and widely studied fact of such sequelae. Twelve cases of ARF (between 1990-1993) who have developed renal dysfunction after prolonged muscular exercise e.g., squat jumping, sit-ups and blunt trauma from sticks or leather belts mainly given by law enforcing personnel for certain issues were studied. None of them had previous history of myopathy, neuropathy or renal disease. All were critically ill on presentation and required renal support in the form of dialysis. Although morbidity was high in all, eleven of them recovered and one expired due to sepsis.
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Beta Haemolytic Streptococci(BHS) carriage rate in pregnant women during labour and its acquisition by their newborns just after birth was investigated in 60 mother baby pairs. The carriage rate of group B Streptococci (GBS) was 11.6%, acquisition rate by newborns of carrier and non-carrier mothers was 85.7% and 1.8% respectively. A total of 28.5% newborns were carrying GBS on all the skin sites and were heavily colonized and therefore, at higher risk of developing early onset of Streptococcal infections. Penicillin G and Ampicillin were most effective antibiotics against GBS.
Repair after resection of a temporomandibular ankylosis can raise the problem of cost and supply. This problem was addressed using the method proposed by M. Benoist which appeared to be particularly adapted to the local situation. A series of 61 joints were operated in 43 patients with resection of the ankylosis block and interposition of preformed acrylic resin heads cemented on a mandibular screw. In the immediate post-operative period, the mouth was maintained in the open position and functional rehabilitation began on the day after the operation. With a follow-up of 12 months, buccal opening was satisfactory in all patients, with a maximum between 28 and 43 mm. There were no indications for material removal, even in one case with screw fracture which occurred without functional impairment. This method is economical and technically simple, only requiring low-cost easy-to-use material and should be more widely used in developing countries.
Frequency of chlamydia trachomatis infection was investigated in eighty-five pregnant women by direct immunofluorescence (IF) and iodine staining methods. The overall frequency of true positive by both methods was 8.2%. Direct immunofluorescence method alone detected chlamydia infection in 16.5% women with 50% sensitivity and 93% specificity and by iodine method in 14.1% women with 58.3% sensitivity and 90.4% specificity. This shows that as compared to IF iodine method is more sensitive and less expensive and easier to perform. The frequency of chlamydia trachomatis infection in our study population appears to be age dependent with younger patients being more likely to be infected than the older patients.
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In a study lasting over two years the frequency and sensitivity of moraxella catarrhalis causing respiratory tract infections were studied. Sputum samples from patients with lower respiratory tract infections were screened for moraxella catarrhalis. The organisms isolated identified and their sensitivity determined by simple methods which are practicable. The study shows that 22.4% of the infections were due to moraxella catarrhalis and 98% of the isolates were sensitive to amoxicillin-culvanalic acid (augmentin). The paper signifies the importance of reporting moraxella catarrhalis and its treatment.
Over the past five years 25,000 blood cultures were screened for septicaemia. Of these 6.7% were positive for salmonella species, the commonest being salmonella typhi accounting for 92% of total salmonella isolates. Over the years, S. typhi showed a gradual decline ranging from 96.7 to 87%. While salmonella paratyphi A has shown a gradual increase ranging from 2.5% to 11.4%. Salmonellosis peaked in the year 1990 suggesting an epidemic. The antibiotic sensitivity pattern showed a gradual increase in resistance over the years and even resistance to the new quinolones has emerged. Thus salmonellosis poses a major threat to the community and we must look into the alternative antibiotics to combat the threat.
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