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Biomedical subjects

S Haastrup

Publications and source records attributed to S Haastrup.

16 recordsLinked to original sources

Drug-use pattern, comorbid psychosis and mortality in people with a history of opioid addiction.

OBJECTIVE: To compare the 15-year mortality of people with a history of opioid dependence that had achieved stable abstinence, with the mortality associated with continued drug use. Another objective was to study the influence of hospitalization with comorbid psychosis on the 15-year mortality. METHOD: In 1984, 188 persons (122 men and 66 women) with a history of intravenous narcotics addiction were interviewed about their drug-use pattern. A registry-based follow-up continued through 1999 and mortality was assessed. Three 1984-drug-use categories were formed. In category 1, cohort members had achieved stable abstinence from drug use by 1984. Using Cox multiple regression analysis, we (i) estimated reduced mortality of category 1 drug users, and (ii) studied the influence of hospitalization with comorbid psychosis on mortality. RESULTS: About 32% had died during the 15-year follow-up. The 15-year mortality associated with stable abstinence was reduced by 56% when compared with the perceived worst drug-use pattern. Hospitalization for comorbid psychosis was not independently associated with mortality in this sample. When drug-use categories were compared with mortality expectations for the general population, the standard mortality rates (SMRs) were clearly elevated. Even in the stably abstinent drug-use category (category 1), SMR was significantly elevated by at least seven-fold in both genders. CONCLUSION: People who had achieved stable abstinence from injecting narcotics use were at lower risk of premature death than people with continued drug use. A residual observed excess mortality in people who had apparently achieved stable abstinence from drug use is consistent with the view of drug addiction as a chronic disease.

Adult↗

Taking cognizance of mental illness in schizophrenics and its association with crime and substance-related diagnoses.

OBJECTIVE: To analyse how committed crimes and substance-related diagnoses are associated with the age on the first contact with the psychiatric hospital system and the age at diagnosing of schizophrenia among schizophrenics. METHOD: In a register-based study including all Danes diagnosed with schizophrenia born after November 1, 1963, data on criminality, substance-related diagnoses and contacts with the psychiatric hospital system were analysed. RESULTS: Compared with the non-convicted schizophrenics the convicted were older on first contact with the psychiatric hospital system and older when the diagnosis of schizophrenia was first given. In contrast, having a substance-related diagnosis was associated with a younger age on first contact but did not influence the age at which the diagnosis of schizophrenia was given. CONCLUSION: It is important that both psychiatrists and the judicial system are aware of possible psychotic symptoms in criminal and abusing individuals to enable earlier detection and treatment.

Adult↗

[Frequency of psychiatric admissions from recently built satellite areas (concrete buildings) in the western district of Copenhagen].

Scandinavian investigations have demonstrated that the extent of mental disturbances is related to the nature of the district concerned. Young satellite districts, concrete built up areas in the periphery of large cities have been pointed out as high risk regions. Environments with poor resources, dominated by social disintegration increase the risk of mental disturbances in persons who are already poorly integrated. Four satellite building sites which were built within the past 25 years in the westerly part of Copenhagen were investigated for the frequency of inpatient admissions in the regional psychiatric department in 1985. 23% of all the admissions occur from these regions where 12% of the basic population lives. The majority of the admissions occur partly from the oldest of these regions built in the nineteen sixties and also from the two youngest regions built at the end of the nineteen seventies. The same pattern was found for the main diagnoses: character disturbances and drug addiction while the diagnosis of schizophrenia is commonest in the two youngest regions. Socio-economical data which suggests social disintegration in these districts is quoted. Purposeful social-psychiatric efforts in the high risk districts are necessary. Mental hygienic requirements should be taken into consideration in planning new residential districts.

Adolescent↗

Eleven year follow-up of 300 young opioid addicts.

A cohort of 300 young opioid addicts (203 male and 97 female) attending the City of Copenhagen Drug Treatment Service (200) or the Nordvang Hospital (100) for first-time treatment during 1973 was personally followed up in 1980 and 1984. In both studies about 90% were traced. Outcome was classified on a four-step scale according to current drug status and occupational status. In 1984 24% of the cohort were classified in the best outcome class while 26% were dead, yielding an average mortality of 2.4% per year. Sixteen per cent were classified as substance users, including persons mostly abusing alcohol or tranquilizers. In contrast to our predictions in 1980 the number of persons achieving stable abstinence does not turn out to be steadily increasing with time. The number of active drug addicts declines mainly because they die, not because they achieve abstinence. According to more strict criteria less than 20% would be classified as truly recovered. Another 5 - 10% achieve some unstable abstinence. The long-term prognosis seems to be highly unfavourable for the study population as a whole.

Adolescent↗

Seven year follow-up of 300 young drug abusers.

300 young morphine addicts in Copenhagen were personally followed up 7 years after their first referral for treatment. The tracking rate was 93.7%. Of the original population, approximately 2% died yearly, i.e. 16%. Each year 5-6% ceased drug abuse, and in 1980, 39% were characterized as being socially well adjusted. In all, 20% remained heavy drug users, though some had changed to other drugs.

Adult↗

Follow-up of 97 young non-psychotic male opiate abusers: relationship between achieving abstinence, age, and duration of abuse.

Ninety-seven young non-psychotic men with intravenous opiate abuse, who had been admitted to a psychiatric hospital, were seen at follow-up 3 years after admission. All were traced. At follow-up, 19% were abstinent, 9% had died, whereas the remainder were still addicted. Those who had become abstinent had done so around the age of 20 and/or before they had been addicted to opiate for 3-4 years, almost regardless of the time at which their total drug abuse had started.

Adult↗