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Biomedical subjects

S Haas

Publications and source records attributed to S Haas.

At least 199 records · Page 11Linked to original sources
PubMed1984

[The traumatic emergency patient in emergency service. Critical evaluation of 718 emergency cases].

The emergency service activities of 718 traumatic cases during a two years period are critically analyzed: Reanimations in traumatic patients are rare (3.8%) and have a bad outcome. Regarding stabilization of vital functions, intravenous infusion is the most frequent kind of treatment (ca. 75%). Compared to other studies endotracheal intubation and ventilation are rather often carried out (greater than 17%). Catheterization of the vena cava is rarely used (less than 3%), coniotomia of the trachea never performed. The emergency doctor's first diagnosis was verified in 97%. In the remainder he was wrong, however, this being of no grave consequence. First aid treatment was adequate in 87% but incomplete in 13%. Nevertheless, incompleteness of treatment did not caused any patient's death.

Adolescent↗
PubMed1982

Influence of heparin; of different heparin fractions and of a low molecular weight heparin-like substance on the mechanism of fibrinolysis.

The influence of different heparin fractions and of a synthetic polysulfated polysaccharide (SP54) on the fibrinolytic mechanism was examined. In vitro, a significant shortening of the euglobulin lysis time (ELT) was found after addition of standard mucosa heparin, of high MW heparin and of SP 54 respectively. Low MW heparin fractions had no influence on the ELT. Simultaneously with the shortening of the ELT an activation of factor XII and of kallikrein was observed. A similar effect was found in groups of volunteers after i.v. or s.c. injections and even after oral administration of SP 54. The effect of venous occlusion on the ELT and on the activation of factor XII was considerably increased when heparin or SP 54 was injected 2 h prior to the test. When a comparable concentration of the test substances was added to plasma samples before and after venous occlusion, the effect on the ELT was much less pronounced than after injection whilst the effect on factor XII was comparable in both tests. From these results the conclusion was drawn that activation of fibrinolysis by polysulfated polysaccharides is achieved by an endogenous pathway as well as by an increased availability of the vascular activator. The magnitude of the activation of fibrinolysis partly depends on the MW of the substance but apparently also on the degree of sulfation since a low MW substance with a high number of sulfate bonds such as SP 54 was considerably more active than the low MW fraction of standard heparin.

Adult↗
PubMed1982

Pimozide versus Haloperidol in acute schizophrenia. A double blind controlled study.

Thirty acutely hospitalized schizophrenic patients were treated under double blind condition with either haloperidol (40-60 mg/day) or pimozide (40-60 mg/day) for 30 days. Ten patients in the pimozide and eleven in the haloperidol group showed a very good or good clinical response. There were no definite differences of treatment results as assessed by the Global Clinical Impression. Both groups showed a statistically significant decrease of the global scores of the Brief Psychiatric Rating Scale (p less than 0.01). There was a significant decrease of affective bluntedness and anergia in the pimozide but not in the haloperidol group. Extrapyramidal side effects were more pronounced in patients on pimozide who therefore needed more anticholinergic drugs. There was no consistent correlation between drug serum levels and global scores or single factors of the BPRS in either treatment group. It is concluded that pimozide in dose ranges from 40-60 mg has powerful antipsychotic properties indistinguishable from those of haloperidol but exerts stronger extrapyramidal side effects.

Acute Disease↗
PubMed1982

Analgesic and euphoric effects of high dose diazepam in schizophrenia.

Schizophrenics treated with high doses of diazepam (150-200 mg/day) showed marked analgesia besides certain antipsychotic effects. Euphoria was noticed in some of the patients. We hypothesized that influence on the endorphin metabolism might contribute to these clinical effects. Therefore, we measured pain threshold by three different methods before and during diazepam treatment. All patients exhibited a 1.5- to 2-fold increase of pain perception. Further, using a double-blind design, the opiate antagonist naloxone (30 mg i.v.) was administered. A significant decrease but not a complete block of the euphoric state and of analgesia was achieved. It is, therefore, concluded that other pharmacological properties of diazepam might be involved in the diazepam-induced euphoria and analgesia in man.

Adult↗
PubMed1981

[Effect of sulfinpyrazone on the platelet function and in experimental thrombosis].

The effect of sulfinpyrazone on various parameters of platelet function was studied in volunteers. The shape change, adhesivity and aggregability of thrombocytes were significantly decreased after an oral treatment with 200 mg Anturano t.d.s. for seven days. Two days after the last medication this effect was still evident. In addition an experimental thrombosis was performed in rats by chilling a standardized segment of the carotid artery. After previous application of 10 and 100 mg/kg BW of sulfinpyrazone the thrombus formation was significantly decreased in comparison with the control group.

Adult↗
PubMed1981

[Activity of plasminogen activators and plasmin inhibitors in the joint capsule in various articular diseases (author's transl)].

The activity of plasminogen activators and plasmin inhibitors in articular capsules of the hip and knee joints in rheumatoid arthritis, chronic traumatic inflammation, arthrosis and aseptic loosening of prosthesis was determined histochemically and correlated with the degree of mobility in osteoarthrosis of the hip. Microscopically unchanged articular capsules were employed as reference sites. In inflammatory articular diseases the plasminogen activator activity was significantly reduced, whereas it remained unchanged in arthrosis and necrosis of the heas of the femur, and significantly enhanced in aseptic loosening of prosthesis. Plasmin inhibitor activity was established in joint capsules with inflammatory changes only; in case of rheumatic inflammation, it was higher than with traumatic inflammation. In osteoarthrosis of the hip there is a positive correlation between joint mobility and plasminogen activator activity. The results point towards involvement of the local fibrinolytic system in joint diseases; however, no definite statement can be made with regard to possible causative linkups.

Arthritis, Rheumatoid↗
PubMed1981

[Experimental approach to the treatment of lupus nephritis by use of an accelerated model of the NZBxNZW mouse disease (author's transl)].

An accelerated model of the NZBxNZW mouse disease is described. The acceleration of the disease was induced by the simultaneous injections of DNA complexed to methylated bovine serum albumin and of bacterial lipopolysaccharide which allow for the production, early in life, of high levels of anti-DNA antibodies. This new model was found to be suitable for therapeutic studies in mice with accelerated disease treated with cyclophosphamide and heparin.

Animals↗
PubMed1980

High dose diazepam in schizophrenia.

The pharmacological properties and the equivocal antipsychotic effects of diazepam reported in the literature suggested the use of high doses of this drug on schizophrenic patients to re-evaluate its usefulness. Treatment of 15 schizophrenic patients with doses of up to 400 mg/day showed a specific effect on hallucinations and certain forms of delusion. One group (nine patients with paranoid-hallucinatory and one with schizo-affective psychosis) showed a significant reduction in psychopathology as documented in the Brief Psychiatric Rating Scale (BPRS) and the Global Clinical Impressions (GCI), whereas five other patients (all of the schizo-affective type with symptoms of depression, euphoria, and/or psychotic anxiety) did not respond and had to be withdrawn from the study. Under the treatment an absence of sedative effects and a development of the feeling of well-being and euphoria were noticed. In three patients with doses of over 260 mg/day a marked loss of inhibitions in sexual and social behaviour was observed. It is concluded that high doses of diazepam may be useful in certain types of schizophrenia.

Adult↗