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Biomedical subjects

S H Tan

Publications and source records attributed to S H Tan.

At least 109 records · Page 6Linked to original sources
PubMed1985

HLA and insulin dependent diabetes mellitus in Singaporean Chinese.

Singaporean Chinese IDDM was significantly associated with AW33, BW58, DR3 and DR4. AW33, BW58 and DR3 being in strong linkage disequilibrium among the Chinese, were associated most strongly with IDDM whose onset was less than or equal to 10 years. The strength of this association showed a significant inverse relationship with age of onset. The frequency of DR4 was significantly elevated on in the 11-20 year IDDM group. The importance of DR3 in Chinese IDDM was also reflected in the observations of joint occurrences of DR antigens. In the less than or equal to 10 years subgroup, the significant association were either DR3/DRW9, DR3/DR4 or DR3/BLANK. In the 11-20 years subgroup, DR4 appeared to be more important and DR4/DR3 and DR4/BLANK were strongly associated with IDDM in this subgroup.

Adolescent↗
PubMed1985

HLA-DR antigens in Chinese children with insulin-dependent diabetes mellitus.

We studied the distribution of HLA-DR and MT1, MT2, MT3 genotypes in 23 Chinese children with insulin-dependent diabetes mellitus (IDDM). The frequency of DR3 was 48% in IDDM children compared to 14% of normal controls (corrected p = 0.0098, RR = 5.70). The frequency of DR4 was not increased. These differences when compared with the results of Western populations may contribute to the relative rarity of IDDM among Chinese children.

Adolescent↗
PubMed1985

Assessment of complications in children with insulin-dependent diabetes mellitus.

Nineteen children with insulin-dependent diabetes mellitus in the University Department of Paediatrics were assessed for complications of diabetes. 36.8% showed marked growth stunting, and half of the patients who attained puberty had a delayed onset of puberty. 42% showed limited joint mobility. Almost all the patients developed hypertrophic lipodystrophy while only 5 patients developed reversible lipoatrophy. Abnormal nerve conduction velocities were found in all 17 patients tested, with more of sensory nerve involvement. A significant correlation was found between duration of disease and the extent of neuropathy. Evidence of nephropathy was found in 5 patients, 2 of whom showed impaired renal function. One patient had background retinopathy, another had proliferative retinopathy and 2 patients developed cataracts. The high prevalence of microangiopathic complications in these children is probably related to their previous poor diabetic control and it is hoped that with home blood glucose monitoring to improve their control, these complications may be arrested or minimized.

Adolescent↗
PubMed1984

HLA-system in Chinese children with insulin-dependent diabetes mellitus: a strong association with DR3.

We studied the distribution of HLA-A, B, and DR and MT1, MT2, MT3 genotypes in all 20 Chinese children with insulin-dependent diabetes mellitus (IDDM) attending the four government pediatric units in Singapore. We found an increase in HLA BW22 but the corrected probability value was not statistically significant. AW33 and B17 were observed in 50% and 55% of IDDM children, respectively, compared with 11% and 13% of normal controls, respectively. The values for AW33 were as follows: corrected P = 0.00094 and relative risk (RR) = 8.17; for B17 they were corrected P = 0.001 and RR = 7.55. In addition, the frequency of DR3 was 50% in IDDM children compared with 14% of normal controls (corrected P = 0.0019, RR = 6.20). AW33, B17, and DR3 are in linkage disequilibrium in our normal Chinese population. All ten patients who were positive for DR3 also had B17. The frequency of DR4 was not increased, and there were no protection IDDM related antigens found. These differences compared with the results in Western populations may contribute to the relative rarity of IDDM among Chinese children.

Adolescent↗
PubMed1983

HLA system in Chinese children with insulin-dependent diabetes mellitus.

HLA in 12 unrelated Chinese paediatric patients with insulin dependent diabetes mellitus (IDDM) were found to have an increased frequency of BW22, B17 and AW33. BW22 was observed in 5/12 (41.7%) of IDDM patients compared to 40/330 normal unrelated Chinese controls (p less than 0.005, rr = 5.2). AW33 and B17 were observed in 6/12 (50.0%) and 7/12 (58.3%) of IDDM patients respectively, compared to 36/330 and 46/330 in the normal controls respectively (AW33: corrected p less than 0.0026, RR = 8.2, B17: corrected p less than 0.0026, rr = 8.6). HLA B8, B15 and B18 did not demonstrate any significant association with IDDM in this series of patients. The results of this study further emphasize the well recognized race specificity in HLA antigen distribution in normal population as well as disease states.

Child↗
PubMed1982

The development of critical care medicine in Singapore.

The development of critical care medicine in Singapore is similar to that in other countries. The fact that intensive care work was not centralised meant that anaesthetists had to attend to patients who were to be found all over a large hospital. Moreover, up to 1967, there was only one ventilator in the Singapore General Hospital although this was commonly used. When open-heart surgery was restarted in 1967, the need for intensive care in the post-operative patients became obvious and a post-basic intensive care nursing course was subsequently started. The quest for an area to centralise intensive care also stepped up and as space in certain wards were generously given toward this cause, intensive care further developed. With the opening of the new Singapore General Hospital, critical care medicine is certainly ready to move toward an even more sophisticated standard.

Critical Care↗