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Biomedical subjects

S H Sklar

Publications and source records attributed to S H Sklar.

9 recordsLinked to original sources
PubMed1985

Herpes zoster. The treatment and prevention of neuralgia with adenosine monophosphate.

Thirty-two adults were enrolled in a randomized, placebo-controlled double-blind trial of intramuscular injections of gel-sustained adenosine monophosphate (AMP) given three times a week for up to four weeks for acute herpes zoster. Adenosine monophosphate moderately reduced the pain soon after the start of treatment, decreased desquamation time, and promoted faster healing of the skin than placebo treatment. Adenosine monophosphate treatment reduced virus shedding and cleared the virus faster than in placebo-treated subjects. At the end of the initial four-week treatment period, 88% of AMP-treated patients were pain free, as opposed to only 43% in the placebo group. After four weeks, all patients who had not recovered from pain started receiving AMP treatment without breaking the code. All these patients recovered from pain within three weeks after initiation of treatment. No recurrence of pain or lesions was experienced from three to 18 months after the end of treatment. Adenosine monophosphate, a natural cellular metabolite, showed no side effects or toxicity during and after the treatment.

Adenosine Monophosphate↗
PubMed1983

Activity of AMP against experimental herpes simplex virus type 1 infections in mice.

Administration of AMP soon after inoculation of mice with herpes simplex virus type 1 inhibited development of virus-induced lesions and appeared to prevent establishment of virus latency. These effects were dependent on both the AMP dose and the time of AMP administration. Regression of herpes simplex virus type 1-induced lesions was also accelerated significantly by AMP treatment in a time- and dose-dependent manner.

Adenosine Monophosphate↗
PubMed1981

Herpes zoster.

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Adenosine Monophosphate↗
PubMed1979

Adenosine in the treatment of recurrent herpes labialis.

The effectiveness of adenosine 5'-monophosphate was tested in thirty-six patients with recurrent herpes labialis. The compound displayed an immediate effect upon the healing of the recurrent lesions. Furthermore, twenty-three patients were free of recurrences for varying intervals extending over 2 years. In the remainder of the treated patients, a single recurrent episode was observed.

Adenosine Monophosphate↗