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Biomedical subjects

S H Sinclair

Publications and source records attributed to S H Sinclair.

40 records · Page 3Linked to original sources

Evidence for vasculitis in acute posterior multifocal placoid pigment epitheliopathy.

A case of acute posterior multifocal placoid pigment epitheliopathy is presented with the unusual feature of the exposure of deep choroidal vessels which filled with dye in the early phase of the fluorescein angiogram in the center of many of the placoid lesions. Visualization of these vessels with surrounding hypofluorescence implies nonperfusion of choriocapillaris presumably due to inflammation, rather than retinal pigment epithelial blockage. The pathology of acute posterior multifocal placoid pigment epitheliopathy is probably a vasculitis of the choriocapillaries, which causes transient occlusion of these vessels and the initial hypofluorescence in the typical lesions during angiography. In many lesions the ischemia is mild enough to cause only temporary disturbance of visual function with subsequent recovery. Only in the center of some of the lesions is the inflammation severe enough to allow for the findings observed in the case presented and to account for the permanent visual defects found in some patients.

Adult↗

Pars plana vitrectomy for macular holes combined with cataract extraction and lens implantation.

BACKGROUND AND OBJECTIVE: To evaluate the safety and efficacy of cataract extraction and lens implantation at the time of pars plana vitrectomy (PPV) for macular hole (MH) repair. MATERIALS AND METHODS: A retrospective study was conducted of 21 eyes that had PPV for MH combined with cataract extraction and lens implantation. Visual acuities (VA) were followed and complications noted. RESULTS: Of 21 eyes, successful anatomic closure was achieved in 16 (76.2%), and 13 (62.0%) improved in VA by at least 2 Snellen lines. Few complications occurred. CONCLUSION: Procedures that combine PPV for MH with cataract extraction and lens implantation decrease the need for future ophthalmic surgery, allow for clearer intraoperative visualization, and facilitate visual rehabilitation. This combined procedure is a relatively safe and effective alternative to separate pars plana and cataract surgeries.

Aged↗