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Biomedical subjects

S H Miller

Publications and source records attributed to S H Miller.

At least 73 records · Page 4Linked to original sources
PubMed1981

A preliminary report on the use of Staphage Lysate for treatment of hidradenitis suppurativa.

Eight patients, 7 with hidradenitis suppurativa and 1 with chronic recurrent staphylococcal abscess, all of whom failed to respond to antibiotic therapy, conservative therapeutic measures, and surgery, were experimentally placed on Staphage Lysate. Treatment after appropriate skin testing consisted of subcutaneous infections of 0.1 ml and intranasal installation of 0.3 ml of Staphage Lysate. Treatments were weekly for twelve weeks, biweekly for six months, and then monthly. Complications, which occurred early, were minimal and involved rash, vertigo, malaise, chills, nausea, fever, and headache. Six of the 8 patients reported noticeable improvement in odor, consistency, and amount of drainage and considerable decreases in pain. Seven of the 8 patients reported improvement in the ability of lesions to drain spontaneously, and a decrease in the frequency of inflammatory nodules. All 8 patients reported that the inflammatory periods were definitely shorter. Early data suggests that Staphage Lysate is a useful adjuvant in the treatment of hidradenitis suppurativa.

Abscess↗
PubMed1981

Effects of transient ischemia on nutrient flow and arteriovenous shunting in canine hindlimb.

A canine model was developed to simulate use of a pneumatic tourniquet in the clinical setting in order to study the acute and delayed effects of transient ischemia on limb and tissue blood flow, using radioactive microspheres and electromagnetic flow probes. Experimental femoral artery flow rose markedly after tourniquet ischemia, and remained significantly elevated for 24 hours (p less than 0.01). Blood flow to the rectus femoris and anterior tibial muscles rose significantly (p less than 0.05) immediately after tourniquet ischemia, and the latter remained significantly elevated at 24 hours (p less than 0.05). Blood flow to the skin of the experimental limbs was elevated significantly (p less than 0.05), immediately ater tourniquet ischemia, and at no other time. Blood flow to the nerves did not increase to its maximum until 15 minutes after tourniquet deflation, and by 24 hours was normal. Tibial and femoral marrow blood flow remained significantly lower in the experimental limb throughout the 24-hour period. Ater tourniquet ischemia (300 mmhg; 2 hours), greatly increased femoral artery flow was related to reactive hyperemia in skin, muscle, and nerve. Twenty-four hours after tourniquet deflation, there was a significant increase in femoral artery and anterior tibial muscle blood flow, and significant arteriovenous shunting from the experimental limb. These data suggest that the hemodynamic response to a transient ischemic injury is more prolonged and of greater magnitude than previously believed.

Animals↗
PubMed1981

Effects of 5,6 benzo-alphapyrone on traumatic edema due to crush and burn injury.

UNLABELLED: Benzopyrones are a class of drugs which have been used clinically and experimentally in Europe and Australia to reduce tissue swelling caused by high-protein edema states. These drugs are not available nor have they been investigated in the United States. This pilot experiment was designed to determine if one of these compounds, 5,6 benzo-alphapyrone, is effective in reducing traumatic edema from thermal and crush injury. METHOD: One hind limb of 34 Sprague-Dawley rats was immersed for 30 seconds in 55 degrees C water and the animals divided into three groups as follows: Group I--no treatment; Group II--17 cc saline/kg body weight IP; Group III--25 mg 5,6 benzopyrone in 17 cc saline/kg body weight IP. In another 30 S-D rats, the soft tissue of the posterior aspect on one hind limb was crushed in a Servistor vise (jaws to within 1 mm of each other) for 5 minutes. They were divided into three groups and treated as in the thermal injury group. After 24 hours both limbs were amputated, weighed, dried, and reweighed. Crushed and burned rat hind limbs treated with benzopyrone after injury had significantly greater dry weights (less edema) than did untreated or saline treated limbs. Benzopyrone appears to be effective in reducing edema following crush and thermal injury in this experimental system. Further studies are being conducted to elucidate the mechanism of action of benzopyrones, their potential activity in other postinjury edema, and their effect on tissue survival.

Animals↗
PubMed1981

Angiokeratoma circumscriptum of the index finger in a child.

A case of angiokeratoma circumscriptum in an unusual location is described and the literature reviewed. Angiokeratoma's clinical resemblance to malignant melanoma is emphasized. Excisional biopsy is advocated as treatment when the diagnosis is in doubt.

Angiokeratoma↗
PubMed1980

Osseous foreign body reaction in the hand.

We report a patient who sustained a puncture wound of the palm and developed an osteolytic metacarpal lesion probably due to an organic foreign body reaction caused by grass and wood.

Bone Diseases↗
PubMed1980

Postmentoplasty hemorrhage from pseudoaneurysm of the inferior labial artery.

A 29-year-old woman underwent rhinoplasty and augmentation mentoplasty. She subsequently developed a pseudoaneurysm of the inferior labial artery. This was responsible for three episodes of delayed, major postoperative bleeding before the lesion was identified and the aneurysm ligated. She has had no further episodes of bleeding.

Adult↗
PubMed1980

Familial multiple lipomatosis.

The literature on familial multiple lipomatosis is reviewed, and a striking case is described. The associated family history is outlined. Excisional biopsy is advocated when there is doubt in terms of diagnosis, pain, or functional impairment.

Adolescent↗
PubMed1980

The circular excision.

A simple, practical alternative to the traditional method of excising small cutaneous lesions is described. It has the advantages of decreased length of final closure and flexibility in determining the orientation of final incisions in areas where it may be difficult to accurately determine skin tension lines.

Facial Dermatoses↗
PubMed1979

Effects of tourniquet ischemia and postischemic edema on muscle metabolism.

In vivo interstitial muscle pressures measured by wick catheter, tissue gas tensions measured by mass spectrometer, and glucose and high-energy phosphate metabolism measured fluorometrically were studied in the anterior tibial (AT) and vastus lateralis (VL) muscles of primate limbs during and following tourniquet ischemia (2.5 hours; 400 mm Hg) to elucidate postischemic edema and its metabolic consequences. During ischemia, interstitial pressure in the VL rose, while in the AT it decreased, but 24 hours later pressures in both experimental muscles were significantly greater than those in the controls. In both experimental muscles PO2 decreased significantly within 15 minutes of ischemia. PCO2 increased significantly in the AT at 30 minutes and at 75 minutes in the VL muscle. Twenty-four hours later only PO2 in the experimental AT was significantly different than its matched control. During ischemia glucose and phosphocreatine (CrP) decreased significantly, and G-6-P and lactate increased significantly in both muscles, but at 24 hours glucose levels were 25% lower and G-6-P 16.2% higher in the experimental AT and CrP 34% lower in the experimental VL. This study shows that there are significant acute and delayed alterations in primate muscle metabolism following tourniquet ischemia and suggests that these changes may be related to the anatomic location of the muscle studied and the type of trauma it has sustained.

Animals↗
PubMed1979

Hemangioma of the temporalis muscle: a case report and review of the literature.

Hemangiomas are the most common benign tumors of infancy and childhood. Most involve skin and subcutaneous tissues and are readily visible. Intramuscular hemangiomas are very uncommon, and rarely appear in the musculature of the head and neck. A 59-year-old woman who had had a lipoma excised from her left temporal region many years earlier underwent excision of a hemangioma of the left temporalis muscle. Intramuscular hemangiomas do not spontaneously involute and should be removed as soon as they are diagnosed, in order to obviate later destruction of the involved muscle and adjacent tissues. Preoperative embolization of the hemangioma may reduce intraoperative hemorrhaging.

Eyeglasses↗