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Biomedical subjects

S H Kaplan

Publications and source records attributed to S H Kaplan.

At least 37 records · Page 2Linked to original sources

Counseling typically provided for depression. Role of clinician specialty and payment system.

BACKGROUND: To assess how current policy trends may affect the use of counseling for depression, we examined the variation in the use of counseling and usual clinician counseling style for depression across specialty sectors (psychiatry, psychology, and general medicine) and reimbursement type (fee-for-service or prepaid). METHODS: Three types of observational data from the RAND Medical Outcomes Study: (1) patient-reported demographics, depressive symptoms, clinical status, and perceptions about participation style; (2) clinician reports of counseling during specific patient encounters; and (3) clinician reports of the usual counseling and interpersonal style across patients who were seen in a practice. RESULTS: While almost all depressed patients who were being treated by mental health specialists received brief counseling for at least 3 minutes, less than half of the depressed patients in the general medical sector received such counseling--even for those patients with a current depressive disorder. Counseling rates were lower under prepaid than fee-for-service care in general medical practices. Psychiatrists relied more on psychodynamic approaches, and psychologists relied more on behavioral therapies relative to each other, but both specialty groups provided longer sessions and used more formal psychotherapeutic techniques (e.g., interpretation) than did general medical clinicians. Clinicians who were treating more patients who had prepaid plans reported a lower proclivity for face-to-face counseling, and they spent less time when they were counseling patients compared with clinician who were treating more patients who had fee-for-service plans; however, these differences were not large. CONCLUSION: The use of counseling in the usual care for depression varied by both specialty and payment system, while the usual clinician counseling style differed markedly by specialty, but only slightly by payment system.

Adult↗

The pH paradox in ischemia-reperfusion injury to cardiac myocytes.

During myocardial ischemia, a large reduction of tissue pH develops, and tissue pH returns to normal after reperfusion. In recent studies, we evaluated the role of pH in ischemia/reperfusion injury to cultured cardiac myocytes and perfused papillary muscles. Acidosis (pH < or = 7.0) protected profoundly against cell death during ischemia. However, the return from acidotic to normal pH after reperfusion caused myocytes to lose viability. This worsening of injury is a 'pH paradox' and was mediated by changes of intracellular pH (pH(i)), since manipulations that caused pH(i), to increase more rapidly after reperfusion accelerated cell killing, whereas manipulations that delayed the increase of pH(i) prevented loss of myocyte viability. Specifically, inhibition of the Na+/H+ exchanger with dimethylamiloride or HOE694 delayed the return of physiologic pH(i) after reperfusion and prevented reperfusion-induced cell killing to both cultured myocytes and perfused papillary muscle. Dimethylamiloride and HOE694 did not reduce intracellular free Ca2+ during reperfusion. By contrast, reperfusion with dichlorobenzamil, an inhibitor of Na+/Ca2+ exchange, decreased free Ca2+ but did not reduce cell killing. Thus, the pH paradox is not Ca(2+)-dependent. Our working hypothesis is that ischemia activates hydrolytic enzymes, such as phospholipases and proteases, whose activity is inhibited at acidotic pH. Upon reperfusion, the return to normal pH releases this inhibition and hydrolytic injury ensues. Increasing pH(i) may also induce a pH-dependent mitochondrial permeability transition and activate the myofibrillar ATPase, effects that increase ATP demand and compromise ATP supply. In conclusion, acidotic pH is generally protective in ischemia, whereas a return to physiologic pH precipitates lethal reperfusion injury to myocytes.

Animals↗

Patient and visit characteristics related to physicians' participatory decision-making style. Results from the Medical Outcomes Study.

This article identifies the characteristics of patients and office visits associated with decreased mutual decision-making between physicians and patients. In the baseline cross-sectional survey of the Medical Outcomes Study we measured specific patient characteristics hypothesized to influence participatory decision-making (PDM) styles of physicians. We related these characteristics to the PDM style scores for their physicians. The study was conducted in solo practices, multi-specialty groups, and health maintenance organizations in Boston, Chicago, and Los Angeles. Over a 9-day period in 1986, 8,316 patients were sampled from the practices of 344 participating Medical Outcome Study physicians, representing general internal medicine, family practice, cardiology and endocrinology. Physicians' PDM style was measured using a 3-item scale included on the baseline questionnaire completed by patients after office visits to their Medical Outcome Study physicians. We found that the elderly (age 75 and older) and young adult (younger than age 30) patients, patients with high school education or less, minority patients, and male patients had the least participatory visits with their physicians. We also found that male patients seeing male physicians had the least participatory visits compared with male patients seeing female physicians, and compared with female patients seeing physicians of either gender. Our data indicated that PDM style increased as duration or tenure of the physician-patient relationship increased. Participatory decision-making style also increased with increasing length of office visits. The role of effective interpersonal care in optimizing patients' health outcomes may be underappreciated. We have identified seven patient and visit characteristics that maximize or compromise the effectiveness of interpersonal care. Recognizing those at risk for suboptimal interpersonal care may be a first step in improving the management of chronic disease. Key words: participatory decision-making style; interpersonal care; doctor-patient communication.

Adult↗

A comparison of various methods of collecting self-reported health outcomes data among low-income and minority patients.

In a randomized trial of different data collection methods, we challenged the untested assumption that reliable data cannot be obtained from lower-income and/or minority patients by self-administered questionnaires. We tested three methods of data collection among a sample of lower-income and minority patients (n = 697) in Indianapolis at a site for the Type II Diabetes Patient Outcomes Research Team. The study included a questionnaire literacy screening instrument to assess patients' functional literacy. Based on their functional literacy, patients were randomized to one of three methods of data collection: mail-out/mail-back, hand-out/assisted, or the in-home interview. We constructed a tiered system for reassigning nonresponders to alternative methods of data collection, using the in-home interview as the fall-back strategy. We compared the response rates, item completion rates, and internal consistency reliabilities of self-reported health status measures between patients with and without literacy limitations and across the three methods of data collection. Patients with and without literacy limitations, across methods of data collection, provided high-quality data, as evidenced by high item completion rates (> 84%) and high reliability assessments (internal consistency reliability coefficients > .80) for each health status measure. As part of the tiered study design, nonresponders randomized to either the mail-out/mail-back or the hand-out/assisted method were interviewed. These patients were significantly older, had significantly lower education and income levels, and had significantly poorer self-reported visual function as compared with those who responded to the originally assigned method. We conclude that expensive, labor-intensive data collection methods, such as in-home interviews, are not necessary for many low-income, minority patients to generate high-quality, reliable health status data. Using appropriate screening instruments, those patient subgroups needing special help can be screening instruments, those patient subgroups needing special help can be identified and targeted for more expensive data collection methods. This tiered approach has policy implications for the cost, feasibility, and quality of data collection in health outcomes research.

Aged↗

Development and testing of a new measure of case mix for use in office practice.

Case mix has been shown to be of critical importance in studies of effectiveness and quality of care using health outcomes. How these variables are defined, combined, and used to adjust or increase precision in tests for differences in health outcomes has been a source of controversy. Because existing measures were developed to adjust mortality and have marginal relevance for the adjustment of functional status outcomes, especially in ambulatory settings, the authors developed a measure of case (or patient) mix that is specifically designed to adjust functional status outcomes measured in office practice or out-of-hospital settings. This measure, developed as part of Type II Diabetes Patient Outcomes Research Team project, uses patients' reports of symptoms and conditions, as well as patients' ratings of symptom intensity to characterize total disease burden. It differs from other measures of case mix in lack of dependence on diagnoses. Separate measures were developed for each of 15 different disease categories (e.g., chronic lung disease) grouped by body system affected. Within each measure, questionnaire items were combined to rate the severity of that disease on a 1 to 4 scale, according to definitions provided by clinicians. A single, global measure was developed by aggregating the 15 measures, weighted according to the expected impact of each disease category on functional outcomes and disability. In a sample of 1,738 patients, significant relationships were observed between the global case mix measure and functional status, disability days, and service utilization.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium.

OBJECTIVE: The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death. METHODS: Isolated arterially perfused rabbit papillary muscles and septa were suspended in a controlled atmosphere and perfused with a modified Tyrode solution containing erythrocytes and trypan blue (500 microM). Ischaemia was produced by arrest of perfusion and withdrawal of atmospheric O2. Extracellular pH of the muscle during reperfusion was controlled by adjusting the pH of the perfusate (pH 6.6 or pH 7.6 with and without DMA 20 microM) and changing the PCO2 of the chamber atmosphere. After 30 min of reperfusion following 30 min (group A) or 60 min (group B) of ischaemia, papillary muscles were fixed with paraformaldehyde. Cell death was assessed by trypan blue staining of nuclei in histological sections of the papillary muscles. RESULTS: The magnitude of cell death was greatest after reperfusion with pH 7.6 as measured by the percentage of nuclei staining with trypan blue (15.1% in group A; 41.8% in group B). By contrast, reperfusion at pH 6.6 reduced cell killing (group A, 3.6%; group B, 7.2%). Reperfusion at pH 7.6 with DMA (20 microM) also reduced trypan blue uptake (group A, 2.8%; group B, 3.8%). Despite the attenuation of cell death afforded by acidosis or Na+/H+ exchange inhibition, significant swelling of the extracellular space and microvascular injury was noted. CONCLUSIONS: Hypercapnic acidosis and Na+/H+ exchange inhibition during reperfusion attenuate lethal reperfusion injury to ventricular myocardium and extend to the intact myocardium the concept of the "pH paradox" in which recovery of intracellular pH after reperfusion is a precipitating factor in lethal cell injury.

Acidosis↗

Principles and practice of case mix adjustment: applications to end-stage renal disease.

For optimal case mix adjustment, it is necessary to build risk or severity models to fit the disease and its outcome. For cardiac disease, for example, several risk models predict the outcome of mortality. These risk models include variables that, by themselves in multivariable models, predict death. If a variable is associated with death independent of treatment or quality of care, it has to be adjusted for and, therefore, included in the model. Similar models have to be developed and tested for end-stage renal disease. A complete risk model would consist of age, sex, the severity of the primary disease of interest (here, end-stage renal disease), not just the presence but also the severity of all co-morbid disease, and, finally, a measurement of functional status or quality of life. This last measurements is associated with outcome beyond and independent of the above noted severity components. These factors (or "severity" or "patient mix" dimensions) then have to be developed in relation to a specific outcome or response variable. Cholesterol and hypertension are risk factors for long-term events and mortality, but not for 2-year symptoms and quality of life. Thus, the model has to be defined by the type of outcome and by the time interval over which the variable acts. For end-stage renal disease, at least one of the major types of outcome will be quality of life. Our case mix measures for hospital co-morbidity and for office practice chronic disease are defined by and intended to predict functional status in the short run, because that is the outcome of interest for dollars spent and for most of the care rendered to patients with chronic disease before the very end stages. Creating a valid case mix or severity measurement aimed at or defined by quality of life thus involves the creation of new models, the testing of those models, the revision based on the empirical testing, and, finally, generalizing to other sites beyond which the data were collected. Useful case mix measurements will be parsimonious, feasible, reliable, validated against the outcome of interest, shown to work in diverse settings, and acceptable to users, especially clinicians.

Activities of Daily Living↗

The uses of outcomes research for medical effectiveness, quality of care, and reimbursement in type II diabetes.

Randomized controlled trials (RCTs), such as the Diabetes Control and Complications Trial (DCCT), usually evaluate the efficacy of a single treatment strategy. The DCCT, for example, evaluates intensive diabetes management aimed at achieving glucose levels as close to normal as possible to modify specific pathophysiological outcomes--specifically, the development or worsening of microvascular disease. In contrast, longitudinal observational studies, such as the type II diabetes Patient Outcome Research Team (PORT) study, address medical effectiveness; that is, how well prevailing treatments work in clinical practice settings. The PORT relies heavily on patient-reported measures of general and diabetes-specific health status, in addition to using complications as major study outcomes. In the type II diabetes PORT, 4,000 patients with type II diabetes and a wide range of socioeconomic, demographic, and disease characteristics, from three widely dispersed geographic settings and varying systems of care, are being followed for a 2.5-year period. Data are collected from periodic self-administered patient questionnaires and from administrative data bases. In the PORT study, nonmutable confounders, such as case-mix, and potentially mutable features, such as patients' preferences for treatment, health habits, regimen adherence, family support, and physician's interpersonal style, are carefully measured. The PORT study will examine the effectiveness of preventive care and established disease treatment in relation to eye, cardiovascular, and extremity disease, measuring and relating use of health-care services to patient outcomes. The results have the potential for maximizing quality of care and minimizing use of services in type II diabetes by matching physician-level profiles of patient outcomes with medical-care-process data and making this information accessible to practicing physicians.

Clinical Trials as Topic↗

Ambulatory testing for capitation and fee-for-service patients in the same practice setting: relationship to outcomes.

Previous studies of the impact of varying reimbursement incentives on physician behavior have not explored the simultaneous implications for patients' health outcomes. Using a single group of physicians who provided care for hypertensive patients with either capitation (N = 99) or fee-for-service (N = 66) health insurance plans, physicians' test-ordering behavior and patients' subsequent health outcomes were examined. After controlling for patients' age, severity of hypertension, and level of comorbidity, it was found that patients with capitation health insurance had fewer laboratory tests and lower overall charges than the fee-for-service patients, with no clinical or statistically significant differences in 1-year health outcomes, specifically blood pressure control. The study concludes that capitation can result in reduction in charges associated with management of hypertension, without apparent compromise in proximate health outcomes.

Adult↗

A comparison of craft use and academic preparation in craft modalities.

The purpose of this study was to compare the use of crafts in psychiatric occupational therapy practice with the actual craft-related training received by occupational therapy students. Two questionnaires were developed, one related to the crafts used in clinical practice, the other related to the amount and type of craft training received in educational programs. One thousand occupational therapists who work in psychiatry and 139 accredited and developing educational programs were asked to complete the questionnaire appropriate to their setting. The final analysis involved 121 educational programs (87% response rate) and 384 clinical programs (38% response rate). The results suggest that there may be substantial differences between craft-related training and actual clinical use of crafts. The findings imply that educational programs must reevaluate the types of crafts taught and the method by which they are integrated into the total curriculum. Implications for the profession include the need to clarify the role of crafts as a therapeutic modality and to reflect on the future direction of the profession.

Art Therapy↗

Assessing the effects of physician-patient interactions on the outcomes of chronic disease.

Growing interest in the doctor-patient relationship focuses attention on the specific elements of that relationship that affect patients' health outcomes. Data are presented for four clinical trials conducted in varied practice settings among chronically ill patients differing markedly in sociodemographic characteristics. These trials demonstrated that "better health" measured physiologically (blood pressure or blood sugar), behaviorally (functional status), or more subjectively (evaluations of overall health status) was consistently related to specific aspects of physician-patient communication. We conclude that the physician-patient relationship may be an important influence on patients' health outcomes and must be taken into account in light of current changes in the health care delivery system that may place this relationship at risk.

Adult↗

Patient reports of health status as predictors of physiologic health measures in chronic disease.

Accurate assessment of health status and forecasting of risk for poor outcomes in chronic disease require a broad representation of health measures. To support this conclusion, the health of patients with diabetes (N = 73) and hypertension (N = 105) was assessed using measures of physical and role functioning, perceived health, and disease severity (blood sugar or diastolic blood pressure, respectively, for diabetes and hypertension). Health questionnaires measuring functional limitations, overall health rating, level of health concern, perceived susceptibility to illness, and number of health problems were administered at study enrollment. Laboratory tests for blood sugar (hemoglobin A1) and diastolic blood pressures were performed at enrollment and were repeated at a subsequent clinic visit, from 3 to 6 months later. Functional limitations correlated significantly with elevated blood sugar (r = 0.57) and blood pressure (r = 0.49) at study enrollment. Perceived poor health was not substantially related to either physiologic measure at enrollment. Using ordinary least squares regression, the best predictor of both blood sugar and blood pressure at follow-up was baseline blood sugar and blood pressure, respectively. However, both functional limitations and perceived poor health made significant and independent contributions to the prediction of blood sugar and blood pressure at follow-up. The results underscore the value of both health survey measures and clinical measures in studies of chronic disease.

Blood Glucose↗

Longevity of restorations: survey results of dentists' estimates and attitudes.

A cross-sectional survey of 571 clinicians was conducted to obtain information about expected and observed restoration longevity. Clinicians believed that average large amalgam, small amalgam, and cast restorations lasted 6, 11, and 13 years, respectively. Patients were thought to be responsible for 47%, dentists for 30%, and materials used for 23% of restoration failures. The clinicians perceived the restorations that they placed to be more long-lasting than those placed by other clinicians. Clinical measurements of restoration longevity were shown to be influenced by the judgment criteria used by clinicians.

Adult↗

Patient education techniques used at burn centers.

Occupational therapists working in facilities with burn units were surveyed to obtain information on their use of education programs with burn patients. Respondents indicated that verbal instruction and written materials that focus on exercise, splint wearing, skin care, and scarring were used most often with patients and families. Almost all 75 respondents indicated that they felt responsible for providing this information to burn patients, and many replied that their patient education programs were generally effective, as determined by patient cooperation and participation in the rehabilitation process.

Burn Units↗