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Biomedical subjects

S H Gottlieb

Publications and source records attributed to S H Gottlieb.

24 records · Page 2Linked to original sources
PubMed1982

Rapid resumption of cigarette smoking following myocardial infarction: inverse relation to MI severity.

In order to identify factors associated with relapse to cigarette smoking, medical and interview data were collected from 66 chronic smokers hospitalized for acute myocardial infarction (MI). Relapse to smoking during the in-hospital recovery period was prevalent (38% of patients). The major correlate of smoking relapse was MI severity, with relapse probability declining as MI severity increased; patients who relapsed to smoking during the recovery period had experienced less severe MIs, as indicated by their serum creatine phosphokinase (CPK) enzyme levels and their requiring significantly shorter intensive-care treatment. Smoking relapse was not related to patients' smoking histories, their reported craving experiences, their reported health beliefs or demographic characteristics. The fact that relapse is most likely among patients with the best medical prognostic status suggests that the benefits of post-MI smoking cessation may have been underestimated in previous studies.

Attitude to Health↗
PubMed1968

The electrical activity of embryonic chick heart cells isolated in tissue culture singly or in interconnected cell sheets.

Embryonic chick heart cells were cultured on a plastic surface in sparse sheets of 2-50 cells mutually in contact, or isolated as single cells. Conditions are described which permitted conjoint cells to be impaled with recording microelectrodes with 75 % success, and isolated single cells with 8 % success. It is proposed that cells in electrical contact with neighbors are protected from irreversible damage by the penetrating electrode, by a flow of ions or other substances from connected cells across low-impedance intercellular junctions. Action potentials recorded from conjoint and isolated single cells were similar in form and amplitude. The height or shape of the action potential thus appears not to depend upon spatial relationships of one cell to another. As the external potassium concentration was increased from 1.3 mM to 6 mM, cells became hyperpolarized while the afterhyperpolarization was reduced. At higher potassium levels, the afterhyperpolarization disappeared, the slope of the slow diastolic depolarization decreased, and resting potential fell along a linear curve with a slope of 61 mv per 10-fold increase in potassium. In pacemaker cells the diastolic depolarization consists of two phases: (a) recovery from the afterpotential of the previous action potential and (b) the pacemaker potential. These phases are separated by a point of inflection, and represent manifestations of different mechanisms. Evidence is presented that it is the point of inflection (PBA) rather than the point of maximal diastolic potential, that should be taken as the resting potential.

Action Potentials↗
PubMedDate not supplied

Physical fitness, physical activity, and fatness in relation to blood pressure and lipids in preadolescent children. Results from the FRESH Study.

PURPOSE: The cross-sectional gender patterns of fitness, activity, and fatness were examined in relation to blood pressure and lipids in 9- to 10-year-old children. METHODS: Subjects were fourth graders (26 boys and 27 girls) participating in FRESH, a school-based heart health program. The main variables of interest were fitness determined on a treadmill, habitual physical activity by self-report, fatness by skinfolds and body mass index, blood pressure, and lipoprotein lipids. RESULTS: Physical fitness and activity were higher in boys, whereas fatness and triglycerides were higher in girls. Systolic blood pressure correlated positively with fatness in girls, and there was a trend for this relationship in boys. In boys, total LDL cholesterol correlated positively with fatness and negatively with fitness. By multivariate analysis, fitness was the primary correlate of total and LDL cholesterol. In girls, fitness correlated positively with total and LDL cholesterol. This finding was opposite in boys. Fatness correlated negatively with HDL cholesterol in boys. CONCLUSION: Boys are more fit and active and less fat than girls. Fatness in young children already shows a relationship with heart disease risk factors. In boys, fitness shows a favorable relation to lipids. These data along with other studies suggest that more consistent relationships among fitness, activity, fatness, blood pressure, and lipids are likely to emerge as children approach adolescence. The findings also underscore the complexity of defining these relationships in young children.

Blood Pressure↗