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Biomedical subjects

S Gupta

Publications and source records attributed to S Gupta.

At least 1,693 records · Page 94Linked to original sources
PubMed1981

Selective migration of T-cell subset in pleural fluid from non-Hodgkin's lymphoma.

Pleural fluid from a patient with non-Hodgkin's lymphoma was examined for lymphocyte subpopulations and their proliferative response to PHA, Con A, and PWM. T lymphocytes were present in a high proportion; in contrast only few B lymphocytes were present when compared to peripheral blood T and B lymphocytes. Among T-cell subsets, Tmu cells were present in high numbers. By contrast Tgamma cells were lacking. Proliferative response to PHA and Con A were normal; however, PWM-induced proliferation was subnormal. This study demonstrates selective migration of a subset of T cells in pleural fluid.

Adolescent↗
PubMed1981

Effect of mode of infection on the development and chemotherapeutic response of Hymenolepis nana in rats.

The susceptibility of rats to Hymenolepis nana (Cestoda) and the chemotherapeutic response of anti-cestode drugs was studied during egg-inducted and cysticercoid-induced infections. In cysticercoid-induced infection, the percentage of infected animals and the number of mature worms were significantly more than in egg-induced infection. The former mode of transmission required more drug to clear the parasites. These differences have been discussed on the basis of immunity engendered in the definitive host by the developing larvae.

Animals↗
PubMed1980

Immunotherapy with oral BCG and serial immune evaluation in childhood lymphoblastic leukemia following three years of chemotherapy.

Thirty-nine children with ALL who had completed three years of chemotherapy were randomized to receive oral BCG for immunotherapy or no treatment as controls. There was not a significant difference between the two groups in the relapse rate. Among the immune parameters, only in vitro blastogenic responses to PHA and PPD rose significantly in the BCG group compared with the controls. Skin testing also revealed evidence of tuberculin sensitization. The group as a whole was studied for the kinetic recovery of immune functions after the cessation of chemotherapy, which revealed a dissociation in both cellular and humoral systems. At three weeks after therapy, only peripheral blood lymphocyte count, non T-cells, and serum IgM showed a significant abnormality. There was a rise in these parameters in the subsequent weeks, and the non-T-cell count reached normal levels sooner than the other two parameters. Children who were less than 5 years of age at the time of diagnosis showed a lesser degree of immunosuppression after long-term chemotherapy compared with those who were greater than or equal to 5 years of age. The analysis of the data indicated a relationship between the low serum immunoglobulins (IgG, IgA) and disease status.

Administration, Oral↗
PubMed1980

Subpopulations of human T lymphocytes. VI. Analysis of cell markers in acute lymphoblastic leukemia with special reference to Fc receptor expression on E-rosette-forming blasts.

A variety of surface markers, terminal deoxynucleotidyl transferase (TdT) activity, morphologic appearance, and cytochemical composition were studied in a group of 16 patients (13 children, 3 adults) with acute lymphoblastic leukemia (ALL). In 9 children, no surface markers were detected on lymphoblasts (null-type ALL). Leukemic blasts of 4 children formed E-rosettes. These E-rosette-forming blasts from 3 adult patients with ALL, were studied for the presence of Fc receptors. Of the leukemic blasts from these 7 patients, 2--76% expressed receptors for IgG Fc. Only 3 of 7 patients showed 9--42% receptors for IgM Fc. In addition, complement receptors were investigated in 6 of those 7 patients with T-cell ALL. Complement receptors were detected on 9--70% of the E rosette forming blasts from all 6 patients. TdT activity was elevated in T-cell ALL and in children with null-type ALL. The heterogeneity of Fc receptor expression on leukemic blasts in these patients demonstrates a malignant proliferation of T cells in different stages of differentiation or maturation. This observation might be helpful in subclassifying T-cell leukemias with regard to prognosis and the response to therapy.

Adult↗
PubMed1980

Childhood CML in blastic stage: an analysis of cell markers and cell kinetics.

The clinical course of Ph+CML and their terminal blastic stage is described in the following case histories. During blastic phase, cell surface markers, terminal deoxynucleotidyl transferase (TdT) activity, and flow cytometric measurements were used or determination of the blast cell phenotype which was undifferentiated by morphological and cytochemical criteria. A high proportion of blast cells expressed Fc receptors for IgG, TdT activity was normal in both children and RNA measurements of single cells flow cytometry showed a high RNA content in the majority of blasts. These findings are compatible with the phenotype seen in the myelomonocytic leukemias. Flow cytometry appears to be a useful adjunct to immunological methods and TdT activity for the rapid characterization of CML in blastic phase.

Child↗
PubMed1980

Primary carcinoma of the gallbladder: a review of 328 cases.

A ten-year retrospective study of 328 histologically proven cases of primary carcinoma of the gallbladder between 1967 and 1976, with a two-year minimum follow-up was undertaken. The overall incidence was 2.9% of all cancer cases and 31.8% of all malignant tumours of the gastrointestinal tract. Male to female ratio was 1:2.64. The disease occurred on the average at a younger age in females (43 years) than in males (50 years). Pain and lump in the right upper abdomen were the commonest clinical features. Laboratory and radiological investigations most often confirmed the diagnosis of advanced disease. The majority (80.8%) were adenocarcinomas. In all the 42 cholecystectomized patients association of gallstones was noted, but as in the majority of cases laparotomy biopsy alone was done, no mention of gallstones was recorded. Five-year survival rate of only 1.8% suggests extensive use of prophylactic cholecystectomy.

Adenocarcinoma↗
PubMed1980

Fibrosarcoma of nose and paranasal sinuses.

Involvement of nose and maxilla by fibrosarcoma is extremely rare. Only a few cases of fibrosarcoma arising in this region are reported in the world literature. Two cases of fibrosarcoma are described, and the literature relating to this disease entity is briefly reviewed. Salient features helping in the diagnosis and management of fibrosarcoma also are highlighted.

Adult↗