Looking at diploid interphase chromosomes.
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Animals↗
Biomedical subjects
S Gunawardena
Publications and source records attributed to S Gunawardena.
Left ventricular volume calculation with integrated backscatter from echocardiography.
Integrated backscatter analysis (IB) is a new echocardiographic method for automatically differentiating tissue from blood on the basis of differences in the amplitude of reflected ultrasound. Left ventricular volume was estimated with IB by use of a modification of Pappus' theorem and a summated ellipsoid method. IB measurements correlated well with a standard biplane area-length method derived off-line from endocardial borders drawn by hand from the same echocardiographic data (y = 1.09 x - 35, r = 0.95). Integrated backscatter measurement of ventricular volume derived from six imaging planes with both the Pappus' rule and the summated ellipsoid methods correlated well with magnetic resonance imaging volume estimates (r = 0.91 and r = 0.90, respectively), whereas use of one imaging plane correlated less well (r = 0.75). Automated analysis of integrated backscatter differentiates tissue from blood sufficiently to allow accurate volume calculations compared with magnetic resonance imaging and to standard hand-drawn echo techniques. This method provides accurate measurement of left ventricular volumes that should be useful in clinical hemodynamic assessments.
Adolescent↗
Multifocal osteosarcoma: an unusual presentation.
PURPOSE: Report the unusual presentation, clinical course, and cytogenetic abnormalities in a child with multifocal osteosarcoma. PATIENTS AND METHODS: A 10-year-old boy had multifocal osteosarcoma involving the entire skeleton, pleura, bone marrow, and lungs. He had marked anemia, thrombocytopenia, and severe hypocalcemia at diagnosis. RESULTS: Despite aggressive chemotherapy, he died from progressive disease 1 month after diagnosis. Cytogenetic analysis of tumor cells within the pleural fluid showed multiple chromosomal abnormalities with amplification of the c-myc oncogene. CONCLUSION: Multifocal osteosarcoma should be considered in the differential diagnosis of a child with pancytopenia and multiple bone lesions. Amplification of the c-myc oncogene may have had a significant role in the pathogenesis, etiology, and rapid progression of this patient's multifocal disease. Additional studies will be needed to determine the biologic significance of c-myc amplification in multifocal osteosarcoma.
Child↗