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S Goto

Publications and source records attributed to S Goto.

At least 757 records · Page 42Linked to original sources
PubMed1990

Steroid-binding peptides from dietary proteins.

The undigested high-molecular weight fraction (HMF) of soybean protein prepared after exhaustive digestion either by microbial proteases or by pepsin exerted a remarkable hypocholesterolemic activity compared to the parent protein in rats fed cholesterol-enriched diets. HMF bound in vitro with bile salts and stimulated fecal excretion of both neutral and acidic steroids far more than did soybean protein. Extraction of HMF with methanol slightly decreased the activity, but the methanol soluble fraction was not regarded as a principle determinant. Further degradation of the methanol-extracted HMF by various proteases resulted in loss of activity. Bile acid binding capacity of HMF from other vegetable proteins was lower than that form soybean protein.

Animals↗
PubMed1990

[A case of mycotic sphenoidal sinusitis with stone formation].

A 40-year-old white female was seen with the chief complaint of recurrent episodes of severe pulsating occipital headache. The headache was temporarily controlled with the treatment of antibiotics only to recur. Sinus X-ray revealed an increased radio-opacity in the left sphenoidal sinus. The sinus walls showed sclerotic reaction. X-Ray CT demonstrated a small piece of metallic density within the soft-tissue density. Intranasal sphenoidotomy was performed under general anesthesia. A small piece of stone, measuring 3 X 2 X 1.5mm, was found in the sphenoidal sinus, with purulent discharge and caseous concrements. Histopathologic examination of the caseous concrements demonstrated fungal hyphae with branching and septate suggesting Aspergillus sp. Chemical analysis of the stone (3mg dried weight) was done and it consisted of calcium phosphate (88%) and calcium carbonate (12%). Postoperative course for five years was uneventful, and postop. CT confirmed the aerated sphenoidal sinus.

Adult↗
PubMed1990

Action pattern of Aeromonas hydrophila chitinase on partially N-acetylated chitosan.

Oligosaccharides from the digestion of 34% N-acetylated chitosan by Aeromonas hydrophila chitinase were separated by CM-Sephadex C-25 column chromatography. Sugar compositions and the sequences of main oligosaccharides were identified through their N-acetylation, their cleavage with exo-glycosidases, and their degradation with nitrous acid. Hetero-chitooligosaccharides such as GlcN.GlcNAc, GlcN.GlcNAc.GlcNAc, GlcNAc.GlcN.GlcNAc, and GlcNAc.GlcN.GlcNAc.GlcNAc, together with GlcNAc and (GlcNAc)2, were detected. The structure of GlcN.GlcNAc was confirmed by the analysis with proton and carbon NMR spectroscopy. These studies indicate that Aeromonas hydrophila chitinase is more specific toward the N-acetyl-beta-D-glucosaminidic bonds in partially N-acetylated chitosan.

Acetylation↗
PubMed1990

[Two different spinal tumors (meningioma and schwannoma) with von Recklinghausen's disease in a case].

Von Recklinghausen's neurofibromatosis is a congenital anomaly due to maldevelopment of the neurectoderm and mesoderm. The disease is known to be commonly associated with other tumors of the neural system. We experienced a case in which two different types of spinal tumors (meningioma and schwannoma) appeared together with Von Recklinghausen's disease. The patient was a 54 year-old female. Her chief complaint was slowly progressive lumbar back pain of about a 10-year duration. She was admitted to our hospital after developing such clinical symptoms as paraparesis, bladder and rectal incontinence, and pain in the soles of her feet. The CT study demonstrated a massive tumor at the TH12-L2 levels accompanied with marked scalloping of the posterior vertebral body. The tumor removed was, histologically, meningioma. During surgery, another small bean-size tumor was incidentally found originating from the dorsal root, and it was identified by histological study as typical schwannoma. It has been reported that the incidence rate of spinal tumors in von Recklinghausen's disease is approximately 4%. Although a case has been reported in which different types of tumors developed in both the cranium and the spinal canal, our case as described above is considered extremely rare as far as we can find in reference literature. The pathogenic mechanism of vertebral scalloping as encountered in our case was thought to be based on interactions between hypoplasia of the supporting tissue and pressure generated by the tumor and CSF.

Female↗
PubMed1990

[A case of cleft lip and palate patient with basilar impression].

Basilar impression is one of bony deformities occurred in the region of the foramen magnum, in which deformity, rim of the foramen magnum or a part of the vertebra impresses into the posterior cranial fossa. Major symptoms of this deformity are short neck, low hair line, torticollis, webbing of neck, pain and limitation of neck movement and various nerve symptoms, when nervous tissue is impressed by rim of the foramen magnum or dens of the second vertebra. This deformity has a characteristic to be found later as a congenital deformity, because nerve symptoms usually do not occur in earlier than 10 years old. The patient was 7 years and 8 months old at his initial visit, whose chief complaint was rotation of upper central incisors which created chewing disorder. When he became 12 years old, because he was taken palsy, walking disturbance, and neck pain in movement, neurosurgery was planned immediately. Edgewise appliance was, then, removed, and orthodontic treatment had to be discontinued until he left hospital. A case was reported of the problems in orthodontic treatment and characteristic of this deformity through our experience for this cleft lip and palate patient with basilar impression in addition to other reports about this deformity.

Child↗
PubMed1990

[Long term results of skeletal profile changes occurring from chin cap therapy of Japanese female skeletal Class III cases].

UNLABELLED: This cephalometric study was made to investigate the effects of chin cap therapy. The subjects were 21 Japanese females of skeletal class III who were treated without tooth extraction. The periods before treatment, during improvement of anterior teeth and after treatment were compared to see where and how effective the therapy had been. RESULTS: 1. Characteristics before the treatment period: These cases had backward position of the maxilla and forward position of the mandible with over growth. In the denture pattern there was a remarkable labioaxiversion of U-1. 2. Characteristics after the treatment period: There was improvement in the backward position of the maxilla. In the forward mandible, once these cases improved their position by improving the overjet, there was a regression followed by gradual forward growth as treatment continued. The denture pattern showed labioaxiversion of U-1 as before. 3. Before the treatment period, these cases showed large Go-Po and Ar-Go in the dimensional linear analysis. After treatment, these analysis showed normal sizes.

Cephalometry↗
PubMed1990

[Morphological characteristics of the cranio-facial structure of Chinese (Taiwanese) young adults].

In this study 26 males (average age: 16 y 9 m) and 23 females (average age: 16 y 7 m) were selected from Chungtai Medical Junior College in Taichung, Taiwan. Head films of these students were traced and analysed. Mean values of the Chinese young adults in Taiwan were calculated and the conclusions were as follows: 1) Linear measurements of this present study were compared to Lin's in both males and females. A significant difference was noticed in the skeletal pattern. 2) Angular measurements of this present study were compared to Lin's data of stage IIIC. The gonial angle of this present study was smaller than Lin's data. However, no significant differences were noticed in the positional relationship of upper and lower jaws. 3) Regarding the axes of the anterior teeth, a lingual tipping tendency of the upper anterior teeth and a labial tipping tendency of the lower anterior teeth were observed. 4) The linear measurements in the present study were compared to the Japanese data of stage V. The anterio-posterior dimension of the chinese maxilla was larger than the Japanese. However, there are no significant differences in the position of the upper and lower jaws in females. 5) The measurements of the mandible in this study were smaller than those of the Japanese data. The gonial and mandibular plane angles, especially, were significantly smaller than those of Japanese. 6) The axes of upper and lower anterior teeth of Taiwanese showed more labial tipping than those of Japanese in this study.

Adolescent↗
PubMed1990

[Two case reports of maxillary prognathism. Some considerations of treatment for different facial type cases].

Generally, prognathism has been just identified as a large overjet. However, for the purposes of treatment, it should be noticed that different facial types are included in this malocclution. Facial pattern is classified into 2 groups; dolico and brachio facial types. The dolico facial type is generally a high angle case. It has a weaker natural anchorage than the brachio facial type. Consequently, it has a downward component in its mandibular growth. The classification of the two different facial types of maxillary prognathism would influence orthodontic treatment. When deciding on the treatment, the differences between the two facial types--in type of anchorage, growth direction, and control of toothaxis--should be taken into account.

Cephalometry↗
PubMed1990

Establishment of hybridomas secreting monoclonal antibodies to placental alkaline phosphatase and development of an enzyme immunoassay for its determination.

We established seven hybridomas secreting murine IgG monoclonal antibodies (MoAbs) to placental alkaline phosphatase (PLAP). The seven hybridomas were designated (1) 7C6, (2) 6G10, (3) 5B9, (4) 6D5, (5) 6B5, (6) 11G6 and (7) 3E10, respectively. The characteristics of these hybridomas were evaluated by radioimmunoassay (RIA) with 125I-PLAP. Their reactivity with the intestinal alkaline phosphatase, one of the alkaline phosphatase isozymes, was (1) 0.04, (2) 0.2, (3) 1.4, (4) 1.8, (5) 0, (6) 4.0 and (7) 6.2(%), respectively. None of them showed signs of cross-reactivity with the liver-type alkaline phosphatase, also one of the alkaline phosphatase isozymes, within a PLAP concentration of 2,000 IU/l. The subtype of 5B9 was IgG1, and that of the others was IgG2a. We then used 7C6, to develop a sensitive, specific and convenient enzyme immunoassay (EIA) for the determination of PLAP, and assayed sera from patients with various gynecologic diseases. The incidence of increased PLAP was 6.4% in patients with benign diseases, 21.5% in cervical cancer, 36.4% in endometrial carcinoma, and 39.5% in malignant ovarian tumors. The specificity for malignant diseases seemed to be higher than that of CA125. Among endometrial carcinomas, well-differentiated adenocarcinoma had the highest incidence of an increased concentration. Among malignant ovarian tumors, serous cystadenocarcinoma, endometrioid carcinoma, dysgerminoma and Krukenberg's tumor showed a higher incidence than the other types.

Alkaline Phosphatase↗
PubMed1990

[Penicillins].

Explore the source record for details and available documents.

Bacterial Infections↗
PubMed1990

Receptor binding of epidermal growth factor in cultured human choriocarcinoma cell lines: effects of actinomycin-D and methotrexate.

Binding of epidermal growth factor (EGF) to its receptor was evaluated in the four cultured choriocarcinoma cell lines BeWo, NaUCC-1, NaUCC-2, and NaUCC-3. Also, the effect of the anti-tumor drugs actinomycin-D (Act-D) and methotrexate (MTX) on the EGF receptor binding was investigated in these cell lines. Incubation of these cells with [125I]EGF at 37 degrees C resulted in a higher binding than that at 22 degrees C or at 4 degrees C. These bindings were saturable during 30- to 60-min incubation, and were specific and reversible. Scatchard analysis showed that the maximal number of receptor binding sites was 2.89 X 10(3)/cell in BeWo cells, 2.04 X 10(3)/cell in NaUCC-1 cells, 1.84 X 10(3)/cell in NaUCC-2 cells, and 1.01 X 10(3)/cell in NaUCC-3 cells. Preincubation with Act-D or MTX for 24 hr decreased the number of receptor binding sites (26%-53%) and slightly increased the receptor binding affinities. Combination of the two drugs resulted in a further diminution of EGF receptor binding sites in BeWo, NaUCC-1, and NaUCC-3 cells, respectively, but reversed the Act-D effect in NaUCC-2 cells. These results indicated that choriocarcinoma tissue is rich in EGF receptors, that the anti-tumor drugs Act-D and MTX diminish the receptor binding sites in the tissue, and suggest that MTX might induce a drug resistance to Act-D in some choriocarcinoma tissue.

Choriocarcinoma↗
PubMed1989

Brain-specific expression of transthyretin mRNA as revealed by cDNA cloning from brain.

cDNAs for rat transthyretin mRNA were cloned from a brain cDNA library. Sequencing analyses showed the presence of an additional 5' sequence that had not been reported for the liver mRNA corresponding to the flanking promoter region of the gene. This additional sequence was expressed only in the brain, suggesting the presence of a brain-specific promoter.

Animals↗
PubMed1989

Regional distribution of metabotropic glutamate response in the rat brain using Xenopus oocytes.

The regional distribution of metabotropic L-glutamate responses was investigated in Xenopus oocytes injected with poly(A)+-RNA from a rat brain which was separated into 3 parts: cerebrum, cerebellum and brainstem. Under voltage-clamp, oscillatory current responses were induced more in cerebellum or brainstem poly (A)+-RNA-injected oocytes, and less in cerebrum poly(A)+-RNA-injected oocytes. These results suggest that the metabotropic glutamate receptor is distributed mostly in cerebellum and brainstem.

Animals↗
PubMed1989

Increased furosemide-sensitive sodium influx into erythrocytes in non-insulin-dependent diabetes mellitus associated with hypertension.

Our previous study demonstrated increased sodium (Na+) influx into ouabain-treated erythrocytes in diabetic patients with hypertension. The present study was designed to estimate the effect of furosemide on the Na+ influx in non-insulin-dependent diabetes mellitus (NIDDM) with hypertension. Both Na+ influx in the absence of furosemide (total Na+ influx; TNaI) and furosemide-sensitive Na+ influx (FSNaI) were increased in patients with essential hypertension (group 1, n = 22) than those in non-diabetic, normotensive control subjects without family history of hypertension (control group, n = 26, P less than 0.001 and P less than 0.001, respectively). TNaI and FSNaI in diabetic patients without hypertension (group 2, n = 28) were also higher than those in the control group (P less than 0.02 and P less than 0.001, respectively), but no significant differences were found in TNaI or FSNaI between groups 1 and 2. TNaI and FSNaI in diabetic patients with hypertension (group 3, n = 19) were elevated than those in control group (P less than 0.001 and P less than 0.001, respectively), in group 1 (P less than 0.05 and P less than 0.02, respectively) and in group 2 (P less than 0.001 and P less than 0.001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗