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Biomedical subjects

S Goren

Publications and source records attributed to S Goren.

At least 19 recordsLinked to original sources
PubMed1998

The dark side of nursing: impact of stigmatizing responses on patients.

The current emphasis in nursing is on caring, what it involves and why it is the profession's responsibility. This article focuses on the opposite behaviors--the "dark side of nursing" (Jameton, 1992). By developing a fuller understanding of nurse behaviors labeled the "dark side of nursing," the profession can better comprehend what caring involves and develop innovative ways to reduce dark-side behaviors. Although marginalizing, labeling and stereotyping, and stigmatizing are related, the focus will be on stigmatizing responses to patients. A number of investigators document nurse stereotyping of suicidal patients, persons with AIDS, racial/ethnic groups, and sex offenders and the impact on patients. Social psychological theories on stereotyping and deviant behavior provide some explanation for the nurse's behavior. The organizational perspective, however, has not been employed to enhance our understanding of nor to eliminate this phenomenon. Combining an organizational perspective with the social psychological theory of negative stereotyping (stigmatizing) and philosophical theory involving ethics provides a more comprehensive theory for understanding the "dark side of nursing" and designing interventions to reduce the occurrence of this damaging behavior.

Acquired Immunodeficiency Syndrome↗
PubMed1997

Pursuit of the ordinary: short-term inpatient treatment.

Short-term inpatient care creates tension between administrative mandates to reduce costs through shortened lengths of stay and staff members' commitment to the philosophy, treatment strategies, and milieu organization associated with extended inpatient care. The attempt to practice as usual within the shortened stay, that is, to do long-term treatment quickly, is bound to fail. Effective short-term care is possible, but only when the culture and treatment approach of the unit are radically altered from those of the traditional model. Short-term inpatient treatment can be understood as the pursuit of ordinary behavior during the inpatient stay. This article offers a set of norms and expectations appropriate for this pursuit.

Adolescent↗
PubMed1994

Meiotic arrest in incompetent rat oocytes is not regulated by cAMP.

Fully grown, but not growing, mammalian oocytes spontaneously resume meiosis in vitro. Resumption of meiosis, also known as oocyte maturation, is associated with a drop in intraoocyte concentrations of cAMP followed by activation of the maturation promoting factor (MPF). Microtubule-associated-protein (MAP) kinase has been suggested as a substrate for the active p34cdc2 kinase, the catalytic subunit of MPF. Our study was designed to explore the mechanism of regulation of meiotic arrest in growing rat oocytes. Confirming previous observations we showed that in our rat colony oocytes do not acquire the competence to spontaneously resume meiosis earlier than 22 days postpartum. We further demonstrated that follicle-enclosed oocytes from 20-day-old female rats fail to resume meiosis in response to luteinizing hormone, follicle-stimulating hormone, a gonadotropin-releasing hormone analog, or forskolin, all of which are known to induce maturation in competent oocytes. Immunoblot analysis using highly specific anti p34cdc2 antibodies revealed that incompetent oocytes express the catalytic subunit of MPF at amounts that are not different from that found in competent oocytes. In addition, highly specific anti MAP kinase antibodies detected the presence of similar quantities of two isoforms (42 and 44 kDa) of MAP kinase in competent and incompetent oocytes. Measurements of cAMP revealed that as compared to competent oocytes, incompetent oocytes contain somewhat lower levels of this nucleotide (1.42 +/- 0.3 and 1.17 +/- 0.07 fmole/oocyte, respectively). However, considering the difference in protein content, the calculated concentrations seem to be similar. Furthermore, similar to competent oocytes, intracellular concentrations of cAMP in incompetent oocytes dropped significantly (from 1.17 +/- 0.07 to 0.77 +/- 0.12 fmole/oocyte) 2 hr after isolation from the follicle. We hereby suggest that (a) in mammals, similar to amphibians, the term meiotic incompetence can be extended to include inability to resume meiosis in response to hormonal stimulation; (b) it is not the lack of p34cdc2 or downstream regulatory elements, such as MAP kinase, that prevents growing oocytes from resuming meiosis; and (c) unlike fully grown oocytes, resumption of meiosis in growing oocytes is not subjected to negative regulation by cAMP.

Aging↗
PubMed1994

Space and sanity.

The political and ideological basis for the organization of space within psychiatric institutions is rarely made explicit, yet space shapes the behavior of both inmates and staff. This article describes the traditional 19th century English asylum and its counterpart in Jacksonian America, as madness-maintaining institutions designed to incarcerate social undesirables. In contrast, nontraditional 20th century institutional architecture based on the Dutch concept of "dwelling," and designed to promote normalcy, is described. A modification of the Dutch model, built in Israel, is illustrated.

Attitude to Health↗
PubMed1994

Maintenance of meiotic arrest by a phosphorylated p34cdc2 is independent of cyclic adenosine 3',5'-monophosphate.

The meiotic division in oocytes is arrested in the G2 phase of the cell cycle. Resumption of meiosis, also known as oocyte maturation, entails a G2 to M transition and is associated with a drop in intraoocyte concentrations of cAMP. Recent studies imply that tyrosine dephosphorylation of p34cdc2 is a prerequisite for entry into the M-phase of the cell cycle. Our study was designed to test the involvement of protein tyrosine phosphatase (PTPase)-regulated dephosphorylation of p34cdc2 in resumption of meiosis in rat oocytes and to explore the possible control of this event by the intraoocyte concentrations of cAMP. Isolated rat oocytes undergoing meiotic maturation spontaneously in vitro served as our experimental model. We found that sodium metavanadate, an inhibitor of PTPase, reversibly blocked the spontaneous maturation in vitro of rat oocytes (ED50 = 0.26 mM). We further demonstrated that the vanadate-sensitive event is completed by 2 h after reinitiation of meiosis. Immunoblot analysis using specific antiphosphotyrosine antibodies revealed that vanadate caused accumulation of phosphotyrosine on a 34-kDa protein, also recognized by anti-p34cdc2 antibodies. The phosphorylated form of p34cdc2 was also detected in oocytes arrested in the G2 phase by the phosphodiesterase inhibitor isobutyl methylxanthine (IBMX). Intraoocyte concentrations of cAMP in vanadate-inhibited oocytes were similar to those in oocytes that resumed meiosis spontaneously in vitro and lower than those in oocytes maintained in meiotic arrest by IBMX (0.73 +/- 0.08, 0.84 +/- 0.09, and 1.42 +/- 0.3 fmol/oocyte, respectively) [corrected]. We conclude that a PTPase that regulates the phosphorylation state of p34cdc2 participates in the control of meiosis in rat oocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

1-Methyl-3-isobutylxanthine↗
PubMed1993

A survey of food service managers of washington state boarding homes for the elderly.

Menus provided by food service managers of boarding homes for the elderly in Washington State were analyzed for nutrient content and frequency with which disease preventive foods were offered. Nutrition knowledge and flexibility of attitudes were measured among the food service managers. Forty-three homes responded. More than half of menus provided by homes exceeded Recommended Dietary Goals for saturated fat, sodium and cholesterol by 33%. Over 60% of menus were deficient (less than 67%) compared to the RDA for zinc, copper and magnesium. Nutrition knowledge and attitude scores of food service managers were not significantly correlated to the frequency with which disease preventive foods were served. Future opportunities for nutrition education should aim at increasing the ability of food service managers to transfer nutrition knowledge into menu planning skills.

Administrative Personnel↗
PubMed1990

Rat oocyte maturation: role of calcium in hormone action.

We studied the role of extracellular calcium (Ca0) in oocyte maturation and oocyte-cumulus cells interaction in rat follicles in vitro. Luteinizing hormone (LH) or a gonadotropin-releasing hormone analog (GnRHa) induced full maturation at [Ca0] = 1.3 mM. At [Ca0] = 0.6 mM, maturation induced by LH or GnRHa was inhibited by 65%. Chelatin of [Ca0] resulted in 45% maturation and neither hormone caused a further increase of maturation. [Ca0] = 20 mM enhanced the response to suboptimal concentrations of GnRHa but inhibited that to LH. Divalent cation ionophores caused [Ca0]-dependent maturation, which was fully inhibited by dibutyryl cAMP. Changes in [Ca0] also affected oocyte-cumulus interaction. At [Ca0] = 1.3 mM, either LH or GnRHa caused partial dispersion of the cumulus. Chelation of [Ca0] also resulted in an almost complete dispersion of the cumulus. The ionophores, however, caused maturation with the oocyte-cumulus complex preserved intact. Our data suggest that GnRHa may induce maturation via cAMP-sensitive calcium mobilization into the oocyte-cumulus-granulosa complex.

Animals↗