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Biomedical subjects

S Gomi

Publications and source records attributed to S Gomi.

121 records · Page 7Linked to original sources
PubMed1984

Cinematographic studies on the A-band length changes during Ca-activated contraction in horseshoe crab muscle myofibrils.

Cinematographic recordings of sarcomere shortening were performed on glycerinated horseshoe crab muscle myofibrils during Ca-activated contraction. When the preparations at slack length (sarcomere length, 7-9 microns) were locally activated with iontophoretically applied Ca ions, the A-band length did not change appreciably while the activated sarcomeres shortened linearly with a velocity similar to the maximum shortening velocity measured on intact muscle fibers. If, on the other hand, previously stretched preparations (sarcomere length, 11-14 microns) were locally activated, the A-band length first increased by 40-50% and then shortened to the initial length, while the activated sarcomeres continued to shorten. These results indicate that the thick filament shortening may not be associated with the physiological sarcomere shortening; the transient A-band lengthening with long initial sarcomere lengths may result from the transient misalignment of the thick filaments followed by their realignment, implying that the force exerted by the cross-bridge is not constant but may vary according to its past history.

Animals↗
PubMed1983

[Neoplastic cardiac tamponade].

Pericardial metastases are frequently found and often cause cardiac tamponade which requires emergency treatment. Pericardiocentesis or subxiphoid pericardiotomy and pericardial drainage can be performed; the latter is a safe and effective method for the management of continuous pericardial effusion since it can be done under direct visualization and local anesthesia. We had four patients with neoplastic cardiac tamponade who were treated successfully with subxiphoid pericardiotomy and pericardial drainage. In three of them neoplasms had not been found until cytology of pericardial fluid proved to be malignant when they were attacked by cardiac tamponade. If the patient with malignancy is attacked by cardiac tamponade, subxiphoid pericardiotomy and pericardial drainage should be performed considering neoplastic cardiac tamponade. We have described pathophysiology, diagnosis and treatment of neoplastic cardiac tamponade.

Adult↗
PubMedDate not supplied

Induction of human leukocyte antigen-A26-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SART1 antigen in patients with cancer with different A26 subtypes.

Peptide antigens available for use in specific immunotherapy of patients with cancer have not been fully determined. Although the authors have reported the SART1 gene encoding epitopes recognized by HLA-A2601-restricted and tumor-specific cytotoxic T lymphocytes (CTLs), the HLA-A26 allele is mainly subdivided into A2601, A2602, and A2603 subtypes. In this study, the authors attempted to determine whether the SART1-derived peptide at position 736-744 (KGSGKMKTE) is suitable to induce HLA-A26-restricted and tumor-specific CTLs in patients with cancer who have these subtypes. This peptide induced the HLA-A26 subtype-restricted and tumor-specific CTLs in HLA-A2601+ or HLA-A2603+ peripheral blood mononuclear cells, respectively. It also induced the HLA-A26-restricted CTL activity in HLA-A2602+ peripheral blood mononuclear cells. Therefore, this peptide could be useful for specific immunotherapy of patients with cancer who have any of the three HLA-A26 subtypes.

Antigens, Neoplasm↗