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Biomedical subjects

S Goldmann

Publications and source records attributed to S Goldmann.

24 records · Page 2Linked to original sources
PubMed1983

HLA-DR-MT matching improves graft survival rate in cadaver kidney transplantation. A prospective multicenter analysis of the South German Cooperative Study Group for Kidney Transplantation.

The influence of prospective HLA-DR matching on the graft survival rate was investigated in a multicenter analysis of 85 transplants. Simultaneously in a retrospective analysis of graft outcome the importance of matching for MT-antigens MT1, MT2 and MT3 as a newly defined B-cell alloantigen system was evaluated. HLA-DR antigens and MT-specificities were determined on B-cells enriched by nylon-wool filtration using locally well characterised HLA-DR antisera and the antiserum set of the 8th International Histocompatibility Workshop ("disease set") which allowed the definition of the HLA-DR specificities HLA-DR 1-9 and of the MT-antigens MT1-3. HLA-DR matching showed a significantly improved graft outcome only in HLA-DR identical donor-recipient combinations. In 11 of 60 patients with one HLA-DR compatibility additional matching for two MT-antigens, however, improved the two year graft survival rate from 60% to 91%. Altogether 17 patients were matched for two MT-specificities with their kidney donor and showed a superior prognosis of 94% at two years compared to 53% or 17% of recipients with one or zero MT compatibility. Graft outcome in this patient group was also superior to that of HLA-DR identical or HLA-AB identical grafts. These data suggested that the MT-system rather than the HLA-DR antigens may be of critical importance in cadaver kidney transplantation. In addition a favorable influence of pretransplant blood transfusions on less HLA-DR matched grafts was confirmed.

B-Lymphocytes↗
PubMed1980

[Increased success rate of renal transplantation by HLA-DR-typing: a retrospective analysis of the South-German co-operative study group for renal transplantation (author's transl)].

Retrospective HLA-DR-typing and the influence of HLA-DR antigen on transplantation prognosis was studied in 90 kidney donor-recipient pairs. It was clearly demonstrated that HLA-DR compatible donor kidney provides a significantly better transplant prognosis than if there is HLA-DR incompatibility. Donor kidneys with only one identical HLA-DR antigen gave a six-month survival rate of 80%. Only HLA-AB identical cadaver kidneys ("full house identity") give similar survival times. Because of relatively lower polymorphism of the HLA-DR alloantigen system, HLA-DR identical donor organs are discovered more frequently than when HLA-AB antigens are taken into consideration. HLA-DR identical donor kidneys (identical for both HLA-DR antigens) have an even better transplant prognosis than "full house identical" kidneys, since the survival rate in the former is 87% after six months.

HLA Antigens↗
PubMed1979

[Performance dependence of the lysine requirement of fattening sows. 1. Effect of energy and amino acid consumption on fattening performance].

Seven variants with graduated energy and amino acid levels were tested at 105 growing sows in a live weight range between 30 and 120 kg. The weight increase and the energy expenditure showed a distinct dependence on the energy level of the ration and are mainly determined by the energy intake. Up to a live weight of 90 kg a 20% lysine over- or undersupply in comparison with the norm had no influence on the growth intensity of the animals. On the low and medium energy levels there was a tendency of superiority of the animals which received feeds rich in protein in the section between 90 and 120 kg. In the variant with a high energy level, however, a diminishing increase was detected in the last third of the fattening period in connection with the growing lysine level. The overall most suitable result was achieved in variant M 120 with a daily increase of 675 g and an energy expenditure of 2.04 kilo energetic feed units for pigs per kg increase.

Amino Acids↗
PubMed1977

[Epidemiology of chronic non-specific pulmonary diseases in Yugoslavia (author's transl)].

In Yugoslavia the diseases of the respiratory system (without tuberculosis) ranges with 23% in front of all other organ-localised diseases. 53--95% of all chronic non-specific lung diseases are registrated in the chest clinics of the different republics. 67% of all lung diseases registrated belong to the obstructive syndrom, 6% are bronchial carcinomas and 27% represent the group of other chronic pulmonary diseases. 31,5% of all patients with chronic obstructive bronchitis are younger than 50 years old, 34,7% are in the age-group between 50-65 years. Assuming the best registered incidence and prevalence rates of bronchial carcinoma, chronic bronchitis, asthma and emphysema in Slowenia as a basis, the expected morbidity of these diseases in each autonomic republic are compared.

Adolescent↗
PubMedDate not supplied

[Lysine requirement of fattening sows depending on their performance. 2. Relations between energy consumption and live weight increase].

105 growing sows in the live weight range were fed with 7 test rations with graduated energy and amino acid levels. The growth intensity was very much influenced by the daily energy consumption. On the basis of regression analysis the following linear relation between daily weight increase (y in g per kg live weight0,75) and the daily energy consumption (x in energetic feed units for pigs per kg live weight0,75) was calculated: y = -13,79 + 0,7037 x (r = 0,84, sb -0,0295). The interpolation with regard to live weight balance resulted in a maintenance requirement of 19,8 energetic feed units for pigs resp. 70 kcal net energy fat for pigs per kg live weight0,75. The methods of assessment chosen showed an increase of the energy requirement per 100 g additional live weight increase per day of a constant amount, independent of the live weight, of 142 energetic feed units for pigs resp. 497 kcal net energy fat for pigs.

Amino Acids↗