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Biomedical subjects

S Goldman

Publications and source records attributed to S Goldman.

458 records · Page 26Linked to original sources
PubMedDate not supplied

Freezing of the esophagus: histological changes and immunological response.

Experimental freezing of the esophagus was accomplished in canines. The temperature used was from -10 degrees C. to -20 degrees C., for from two to ten minutes. Histological studies revealed cryonecrosis, limited to the cells immediately in contact with the probe surface, edema and cryothrombosis, as the most outstanding and significant histological lesions. Preliminary evaluation of the effects of in situ freezing of the esophagus is suggestive of the development of a cellular response. This response appeared to be directed to antigens present in extracts of esophageal mucosa and muscularis. Repeated in situ freezing of the esophagus resulted in the development of an increased (i.e., anamnestic), immunologic response to mucosa and muscularis antigens. The results of this experiment suggest the use of freezing techniques as an alternative to total esophageal resection for early carcinoma of the esophagus. The 98% cure rate of freezing techniques in the squamous cell carcinoma of the skin encourages us to emphasize the possibility of using this technique with a similar degree of success in early carcinoma of the esophagus.

Adenocarcinoma↗
PubMedDate not supplied

[Clinical applications of positron emission tomography].

Positron emission tomography (PET) is a non invasive method of medical investigation which allows visualization and quantification of functional and metabolic data at the level of target organs. PET gives access to biological data on regional blood flow, energetic metabolism, synthesis and binding processes. In the brain, PET allows the study of different processes related to neurotransmission. PET provides data on cellular changes related to injuries, dysfunctions or abnormal proliferation. Diagnostic value of PET informations has been documented in several diseases, mainly in neurology, cardiology and oncology. The expected development of PET is related to advances in new radiotracers chemistry.

Adult↗
PubMedDate not supplied

[Decrease in the frontal-superobasal metabolic ratio in unipolar depression].

Cerebral frontal glucose metabolism was investigated in 12 unipolar depressed patients and compared to these of 12 healthy volunteers using Positron Emission Tomography (PET) and (F18) fluorodeoxyglucose. The PET investigation was made in a quiet room with a dimly light and each subject remained in a resting state with closed eyes. Results show a decreased in a frontal superobasal calculated ratio in depressed patients compared to control subjects for left and for right values. This reduction indicates an imbalance between the frontal and the superobasal region. This imbalance could relate to some particular depressive symptom profile.

Adult↗