Relationships among clinical response, extrapyramidal syndrome and plasma chlorpromazine and metabolite ratios.
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Biomedical subjects
Publications and source records attributed to S Goldberg.
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Two cases of intrathoracic meningocele are reported: their association with neurofibromatosis is stressed. The likelihood of a posterior mediastinal mass occurring in a patient with neurofibromatosis being a meningocele is emphasised. A review of the literature is presented. In view of the relatively few cases of intrathoracic meningocele with neurofibromatosis documented since 1933, we feel justified in reporting these 2 cases.
A patient with a sarcoma of the tibia associated with multiple bone infarcts and a history of alcoholism, is presented. This is a rare association. The possible aetiological role of bone infarcts in relation to the development of a sarcoma is discussed.
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The optic fiber layer of the avian retina, as seen in flat mounts, contains morphological markers of vertical and horizontal polarity. Optic vesicles were rotated in chick embryos prior to the appearance of the optic fiber layer. Later, the optic fiber pattern was examined to determin if its polarity was inverted, or upright or if its right-left asymmetry changed. Large grafts showed no tendency toward axial realignment, regardless of the stage of operation. Moderate size grafts became realigned mainly by derotation. In this process the vertical axis of the graft showed a greater tendency to derotate than the horizontal axis. Thus, left-to-right transplants, when performed prior to embryonic stage 12, developed as left retinas with normally aligned vertical axes, regardless of the degree of operative rotation. Small grafts mainly showed cross-axial regulation, as opposed to derotation; the polarity of the horizontal axis became fixed prior to the vertical axis. The equatorial zone of the optic vesicle, which lies about midway between the distal tip of the vesicle and the midline of the embryo, was included in moderate size, but not in small grafts. This zone appears critical in the transfer of morphological information to the developing retina.
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In HeLa cells, about half the hnRNA is synthesized from transcription units which are less than 5000 bases in length, although over 80% is larger than the average mRNA. This conclusion was derived from a quantitative analysis of the nascent chain sedimentation profile.
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This publication describes a relatively simple transnasal and trans-septal surgical approach to the sphenoid sinus, that assists in the diagnosis of pathology in this region and in some circumstances permits the correct treatment. Eight patients on whom this technique was used, are briefly reported. The importance of adequate radiological assessment of this area is illustrated.
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