Pregnancy with frozen-thawed and fresh testicular biopsy after motile and immotile sperm microinjection, using the mechanical touch technique to assess viability.
Explore the source record for details and available documents.
Biopsy↗
Biomedical subjects
S Glina
Publications and source records attributed to S Glina.
Anxiety and high plasma catecholamines do not impair pharmaco-induced erection of psychogenic erectile dysfunctional patients.
The aim of this study was to assess the influence of anxiety and plasma catecholamines on the pharmaco-induced erection of psychogenic erectile dysfunction (ED) patients. A total of 23 patients with psychogenic ED aged from 19 to 43 y were submitted to: (1) anxiety evaluation by the Spielberger's State and Trait Anxiety Inventory-STAI; (2) intracavernous injection of PGE1 10 microg+phentolamine 1 mg with the response monitored by Rigiscan; (3) blood sampling from cavernous bodies and cubital vein for adrenaline and noradrenaline levels determination by high performance liquid chromatography. The whole procedure was done in a single clinical setting at the same day. We found no significant correlation between the erection rigidity and the cavernous or peripheral catecholamines or between erection rigidity and anxiety scores. Some patients showed rigid erections despite high anxiety scores or penile catecholamine levels while others, with incomplete erections, had much smaller levels. These results are suggestive of a more complex mechanism controlling the penile sympathetic responsiveness in psychogenic ED patients.
Adrenergic alpha-Antagonists↗
Erectile dysfunction: prevalence and associated variables in patients with chronic renal failure.
Patients with chronic renal failure (CRF) experience a significant decrease in quality of life, due both to the limitations imposed by the disease as well as the demands of the treatment that they receive. Some side effects of both illness and treatment contribute to increase the morbidity of these patients. Among them, erectile dysfunction (ED) is notable. One hundred and nineteen patients received clinical and laboratory evaluation. The following clinical data were observed: age, education, income, race, period of dialysis, period of complaints of ED, etiology of ED, use of erythropoietin, presence of arterial hypertension and/or diabetes mellitus, use of antihypertensive drugs, use of cigarettes, and psycho-emotional state of the patients. Assessment of complaints of ED was achieved using the International Index of Erectile Function (IIEF). The following laboratory data were analyzed: hemoglobin, hematocrit, free testosterone, gonadotrophin levels (FSH and LH), HDL-cholesterol, total cholesterol, prolactin, and parathyroid hormone. Statistical analysis of the means of continuous variables was performed through use of the Student's t-test. Analysis of significance of category variables was performed using the chi(2) test. Descriptive analysis was obtained through use of the clinical and socio-demographic data. A multivariate model was created and the odds ratio calculated. The average age of the patients was 47.3+/-15.9 y. The mean duration of erectile dysfunction complaints was 4 y. The average duration of dialysis was 66.2+/-58.9 months. Prevalence of erectile dysfunction in this population was 57.9%. The main known etiology of chronic renal failure was glomerulonephritis. The main variables associated with erectile dysfunction were age, psycho-emotional state, and levels of HDL-cholesterol. This study showed a high prevalence of erectile dysfunction in the group of patients examined. Factors such as age, anxiety and depressive complaints, and dyslipidemy seem to play an important role in the origin of erectile dysfunction in such patients.
Adult↗
Erectile dysfunction in Latin America and treatment with sildenafil citrate (Viagra): introduction.
Explore the source record for details and available documents.
Erectile Dysfunction↗
Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men.
A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum etiology. Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P<0.0001) higher in the sildenafil group (n=109) than in the placebo group (n=105). These findings confirm the significant increases in frequency of penetration and frequency of maintained erections reported previously. Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men.
Administration, Oral↗
Vasculogenic impotence and cavernosal oxygen tension.
Explore the source record for details and available documents.
Arteries↗
The value of a second injection on the pharmaco-induced erection test.
In order to test the capability of a reinjection to improve an incomplete pharmaco-induced erection, we submitted 30 impotent patients, with incomplete erectile responses to 10 micrograms PGE1 + 1 mg phentolamine, to a second injection of 15 micrograms PGE1 + 1.5 mg phentolamine + 30 mg papaverine, fifteen minutes after the first injection. Twenty-one patients improved their erection including nine who achieved complete rigidity. We conclude that incomplete pharmaco-induced erections can frequently be improved by reinjection.
Adrenergic alpha-Antagonists↗
Veno-occlusive dysfunction of corpora cavernosa: comparison of diagnostic methods.
Pump cavernosometry, pharmaco-cavernosometry, gravity cavernosometry and the intracavernous pressure drop test are the most used tests for the diagnosis of venoocclusive dysfunction. To verify whether patients show equivalent results in each of these four tests, and to ascertain whether there is any influence of the sequence of the exams over the results, 123 male patients with erectile dysfunction, aged 21 to 82 years (mean 48), were evaluated. All were submitted to the four tests in randomized sequence. Two criteria were used to define the normal results of pump cavernosometry and pharmaco-cavernosometry, both based on patients with normal veno-occlusive function. The incidence of normal results varied from 6.5% in pump cavernosometry according to criterion I to 64.2% in pharmaco-cavernosometry according to criterion II. Results of the four tests agreed completely (all normal or all abnormal) in 43.9% of the patients when criteria I was used and 58.3% with criteria II. Incidence of normal results in each test did not vary according to the sequence in which the exams were done. Pump cavernosometry, pharmaco-cavernosometry, gravity cavernosometry and intracavernous pressure drop test did not show equivalent results for individual patients. Results were not influenced by the sequence of the tests.
Adult↗
Penile prosthesis surgery with the patient under local regional anesthesia.
A total of 20 patients underwent penile prosthesis implantation while under local regional anesthesia with a pudendal nerve blockade at the perineum. The method is safe, performed as an outpatient procedure and showed no complication. It avoids the need to inject a local anesthetic intracorporeally, which is risky in elderly patients.
Ambulatory Surgical Procedures↗
Gravity cavernosometry--a simple diagnostic test for cavernosal incompetence.
The papaverine test has been widely used as a diagnostic procedure in erectile impotence. However, when patients do not achieve full erection on the test, it is necessary to differentiate between insufficient inflow and excessive outflow. Gravity cavernosometry is a method designed to evaluate the pressure responses in the corpora when they are subjected to a constant infusion pressure. The infusion flow is of minor significance. The intracavernous pressure (ICP) was measured in cadavers, in psychogenically impotent patients and in patients with arteriogenic impotence, following administration of papaverine and gravity perfusion. During perfusion in cadavers and in psychogenic patients, the ICP showed values above 110 cm H2O, while in arteriogenic patients the values ranged from 30 to 141 cm H2O. In the arteriogenic group, 11/20 patients had an ICP lower than 110 during perfusion. There was no correlation between the pre-perfusion pressure and the final pressure with perfusion. Gravity cavernosometry is a simple, cost-effective and reliable method for the assessment of corporeal competence.
Adult↗
Surgical exclusion of the crural ending of the corpora cavernosa: late results.
Twenty-three patients with corpora cavernosa incompetence responsive to perineal compression were submitted to surgical exclusion of the crural ending of the corpora cavernosa. There were two mild complications: perineal hematoma and incisional pain for 10 days. At the end of the first month, 65% of the patients claimed better erections, and the late good results were 47.7%, with an average follow-up period of 18.9 months. Three of the failed cases were later submitted to a penile prosthesis implantation.
Erectile Dysfunction↗
[Correction of distal hypospadias by urethral meatal advancement neo-urethroplasty-glandoplasty].
Distal hypospadias are the most frequently observed, and represent about 70% of all forms of this condition. In recent years, due to the introduction of simpler procedures which produces better results, the surgical correction of this small defect has been universally accepted. It offers a normal penile appearance and prevents associated psycological effects. In this work we evaluated the surgical correction of distal hypospadias by means of meatal advancement-neouretroplasty-glanuloplasty in two hundred patients. Good cosmetic and functional results were obtained in 86,5 and 97,0% of the cases, respectively. All patients had their urinary stream directed forward. The more important complications verified were neomeatal retraction, urethrocutaneous fistula and neomeatal stenosis in 13.5, 3.0 and 0.5%, respectively. The complications observed did not represent a worsening of the initial condition, and in almost all such cases it was corrected with a complementary procedure on an ambulatory basis or in one day of stay at the hospital, as the previous surgery.
Adolescent↗
Impact of cigarette smoking on papaverine-induced erection.
Owing to the vasoconstrictive effect of nicotine, smoking may potentially interfere in the results of the drug-induced erection test for papaverine hydrochloride. To investigate the effect of smoking on this test, 12 patients between 22 and 65 years old underwent the following protocol: phase 1--intracavernous injection of 100 mg. papaverine hydrochloride with measurement of intracavernous pressure by puncture with a 19 caliber butterfly needle attached to an aneroid manometer and phase 2--1 week after the initial test the procedure was repeated after the patient smoked 2 cigarettes. In phase 1 all men obtained a full erection, compared to only 4 in phase 2. The average intracavernous pressures were 85.83 and 53.50 mm. Hg, respectively, in phases 1 and 2 (p less than 0.01). We conclude that cigarette smoking, probably through nicotine, interferes with the drug-induced erection test, which might explain some false negative results.
Adult↗
Urethral prolapse in girls: familial case.
Explore the source record for details and available documents.
Child, Preschool↗
Leakage through the crural edge of corpus cavernosum. Diagnosis and treatment.
Blood drainage of the corpora cavernosa is made by the deep dorsal vein and by the deep crural veins. The root of the corpora can be compressed against the ischium during papaverine test or cavernometry. In a series of patients with cavernosal leakage, this maneuver demonstrated that the crural edge of the corpora is the point of leakage in many of them. Exclusion of the crural edge by ligation of the corpora proximal to the entrance of the arterial supply caused improvement of erections in 7 of 8 patients.
Erectile Dysfunction↗
Segmental priapism.
A case report of a 27-year-old male with segmental priapism of the left proximal corpus cavernosum is presented. Treatment consisted in evacuation and irrigation of the corpus.
Adult↗
[Stenosis of the renal artery as a cause of acute renal insufficiency after transplantation].
Eight cases of kidney transplant recipients that developed acute renal failure are described. Arterial renal stenosis was responsabilised for the ARF. One patient was submitted to transluminar angioplasty without success and then operated. This technique was the successful treatment in another patient. Four patient were submitted to surgical correction as first therapeutic approach. Two patients received no specific treatment. From the six treated patients five had good evolution.
Acute Kidney Injury↗
Vesical haemangioma. Report of two cases.
Two cases of vesical haemangioma and a review of the literature are presented. In one of the cases association with cutaneous "Blue Rubber Bleb Nevus" has been found. Vesical haemangioma is a benign tumour, probably of congenital origin, that occurs in young patients. The first symptom is generally haematuria, and diagnosis is confirmed by cystoscopy. The treatment of choice is partial cystectomy, and the most common histologic form is cavernous haemangioma.
Adult↗