Biomedical subjects

S Glaser

Publications and source records attributed to S Glaser.

57 records · Page 4Linked to original sources

PubMedDate not supplied

[Anamnestic factors in at-risk SID children with peculiar breathing pattern].

436 out of about 9000 infants who were born between April 1987 and November 1990 in Jena were selected by means of a risk score for a polygraphy monitoring. This score contains anamnestic factors of the mother and the infant which are characteristic of an enhanced risk for the sudden infant death syndrome (SIDS). We performed a day-time polysomnography (ECG, heart rate, respiration, EEG, EOG, EMG) with a sleep duration of at least one hour. 23 of the infants investigated demonstrated abnormal breathing patterns (increased mean apnea duration, apneas longer than 15 s, apneas with bradycardia) and were treated with aminophylline to prevent a possible SIDS event. Now we investigated the statistical relation between 26 anamnestic factors of our risk score and the need for treatment. In univariate statistical comparisons treated infants differed from untreated infants concerning the occurrence of intraventricular haemorrhages (IVH), the gestational age (GA) (preterm of fullterm) and the occurrence of hyperbilirubinemia (HB) in their anamnesis. In a multivariate analysis with all 26 factors the birth weight was the third important factor beside IVH and GA, but only factor IVH was statistically significant. A cluster analysis of the variables with respect to the separation of the two groups of infants indicates that the variables IVH, GA and HB strongly correlate. In the light of these results we can underline that abnormal breathing patterns can be expected especially in infants with IVH, short GA and low birth weight.

Aminophylline↗

PubMedDate not supplied

[The diagnosis of sleep apnea--possibility for the prevention of SID?].

Groups of children with a statistically enhanced risk for SIDS: siblings of SIDS-victims and other full-term and preterm infants with anamnestic signs for an enhanced risk of SIDS and a control group of healthy infants without anamnestic signs of risk were polysomnographically investigated in the first year of life. The mean apnoea duration (MA-value estimated by frequency and length of apnoeas greater than or equal to 3s) in the sleep states active and quiet sleep was calculated. During active sleep there is a significant inverse correlation between MA and postnatal age in the full-term and preterm SIDS-risk infants but not in the controls and siblings of SIDS-victims. In all age groups there are some children in the full-term and preterm infants with extremely enhanced MA-values. For 6 age groups of the first year of life the 90% percentile of the MA-value was calculated separately in the sleep states active and quiet sleep to select infants with an abnormal breathing pattern. This limit could be a help for the decision on therapy.

Electrodiagnosis↗

PubMedDate not supplied

[A screening program for detecting children with an increased SIDS risk (sudden and unexpected infant death)].

The prospective study presented conducted to prevent SIDS (sudden infant death syndrome). One of the proposed hypotheses on SIDS postulates a brainstem abnormality in the neuroregulation of cardiorespiratory processes. Therefore we characterized cardiorespiratory control mechanisms by examining the neurotransmitter substance P in plasma and polysomnographic investigations. With respect to the probable multifactorial origin of SIDS we selected children firstly anamnestically by means of an epidemiologically evaluated pre-, peri- and postnatal risk score. We reported the results of 208 polysomnographically and biochemically examined children anamnestically selected from a group of 2500 neonates. Examinations were performed on infants aged 2-4 weeks up to 1 year. To characterize respiratory control, length and frequency of apnoeas were separately estimated by means of polysomnography in the sleep states active and quiet sleep. If there were polygraphic risk factors representing a disturbance of respiratory control, the children were prophylactically treated with aminophylline 3 x 3 mg/kg b.w. for 4 weeks. We found a significant age dependence both of the mean apnoea duration in active sleep and the substance P level in plasma in the SIDS-risk group but not in the controls. High mean apnoea duration was correlated with low substance P level in the first months of age in SIDS risk infants selected anamnestically. This may reflect a delayed maturation of respiratory control mechanisms. In this way the polysomnography and the investigation of the neuropeptide substance P may be useful for a screening method indicating wether the respiratory control mechanisms are mature or not.

Aminophylline↗