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Biomedical subjects

S Gaspar

Publications and source records attributed to S Gaspar.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

The role of the spectral sensitivity curve in the selection of relevant biological dosimeters for solar UV monitoring.

To estimate the risk of enhanced UV-B radiation due to stratospheric ozone depletion, phage T7 and uracil thin-layer biological dosimeters have been developed, which weight the UV irradiance according to induced DNA damage. To study the molecular basis of the biological effects observed after UV irradiation, the spectral sensitivity curves of the two dosimeters and induction of the two major DNA photoproducts, cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts ((6-4)PDs), in phage T7 have been determined for polychromatic UV sources. CPDs and (6-4)PDs are determined by lesion-specific monoclonal antibodies in an immunodotblot assay. Phage T7 and uracil biological dosimeters together with a Robertson-Berger (RB) meter have been used for monitoring environmental radiation from the polar region to the equator. The biologically effective dose (BED) established with the three different dosimeters increases according to the changes in the solar angle and ozone column, but the degree of the change differs significantly. The results can be explained based on the different spectral sensitivities of the dosimeters. A possible method for determining the trend of the increase in the biological risk due to ozone depletion is suggested.

Atmosphere↗
PubMedDate not supplied

Electroclinical correlations in temporal lobe epilepsy.

2,698 epileptic patients were studied, 2,019 cases (64.3%) presenting temporal lobe epileptic attacks. Besides the routine EEG recordings and the corroboration of the clinical data with the meticulous observations by video monitoring on a closed circuit TV-screen (the patients being observe in a specially arranged room, provided with infra-red cameras), the diagnostic procedure was supported in all cases by several computerized EEG mappings, according to a model achieved by us, transcribing the primary data obtained by Hjorth's NSD parameters from the Siemens-Elema Mingograph to a Romanian M-118 microprocessor. In many cases we utilized an interface--built by us--for analog-digital conversion which allowed the direct introduction and conversion of amplitudes and frequencies from the Mingograph to the micro-computer. These were isolated to analyse the following electroclinical forms: 1. temporal absences: 360 cases (17.8%); 2. psychomotor attacks: 439 cases (21.7%) 3. psychosensory attacks: 77 cases (3.8%); 4. attacks with cognitive symptomatology: 260 cases (12.8%); 5. crises with ideative-affective symptomatology: 76 cases (3.8%); 6. vegetative attacks: 51 cases (2.5%); 7. akinetic attacks: 89 cases (4.4%); 8. focal temporal attacks secondarily generalized: 667 cases (33.0%). In 112 patients with nocturnal attacks, polysomnographic recordings were performed with sequential computerized EEG mappings during the various stages of sleep (concomitantly with the infrared video-TV monitoring).

Adult↗
PubMedDate not supplied

[Variations in parathormone serum levels during treatment of Paget's disease with calcitonin of human or salmon origin (author's transl)].

Biological effects of increasing doses of human and salmon calcitonin (CT) have been studied in 17 patients suffering from Paget's disease of bone. Results show a dose response relationship on indirect indices of bone turn-over. The plateau phenomenon occurs with both CT and more rapidly with the lower dosage. There is also a transient increase in parathyroid activity during the period of time when bone turn-over is decreasing. Calciuretic effect was more pronounced with salmon than with human CT.

Alkaline Phosphatase↗