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S Gandolfo

Publications and source records attributed to S Gandolfo.

At least 55 records · Page 3Linked to original sources
PubMed1995

[Recurrent aphthous stomatitis: current etiopathogenetic and therapeutic concepts].

The authors review the literature on aetiopathogenesis and therapeutic management of recurrent aphthous stomatitis. The data regarding the role of genetic, nutritional and microbiological factors in the genesis of recurrent aphthous stomatitis has been particularly examined. Despite significant associations with some antigens HLA have been reported in Southern Europe, there is no clear genetic predisposition in recurrent aphthous stomatitis. Several studies have analyzed the importance of iron, folic acid and vitamin B12 deficiencies, gluten intolerance and sensitivity to certain foods in the triggering of recurrent aphthous stomatitis however the results have been controversial. Recently, it has been suggested that recurrent aphthous stomatitis could be caused by reactivation of varicella-zoster virus and/or cytomegalovirus but these viruses may be reactivated by the immunodysregulation known to underlie recurrent aphthous stomatitis. Moreover, antiviral drugs appear to have only an equivocal effect on recurrent aphthous stomatitis. Recurrent aphthous stomatitis is probably determined by immunological mechanisms although there actually no unifying hypothesis which attempt to integrate the results of the many immunologic studies on recurrent aphotous stomatitis. Moreover, the target antigen and the cause of recurrences of recurrent aphthous stomatitis are still unknown. As far as the management of this disease it is important to recognize recurrent aphthous stomatitis secondary to systemic diseases like Behcet's syndrome, gluten enteropathy and haematinics deficiencies. Subsequently, the symptoms can be reduced with several drugs (mainly topical corticosteroids) but there are no effective therapies preventing recurrences.

Adjuvants, Immunologic↗
PubMed1994

Oral lichen planus and hepatitis C virus (HCV) infection: is there a relationship? A report of 10 cases.

Ten patients are reported suffering from oral lichen planus (OLP) associated with chronic liver diseases linked to HCV. All patients were affected by varieties of erosive oral lichen planus. In six of these 10 patients the diagnosis of HCV was made as a result of the OLP diagnosis and four of them had unknown, but severe, chronic liver disease. These preliminary data support the possible existence of a relationship between oral erosive lichen planus and HCV infection.

Aged↗
PubMed1994

Can Ki67 immunostaining predict response to radiotherapy in oral squamous cell carcinoma?

AIMS: To determine whether immunohistochemical evaluation of the abatement of proliferating cells after a first course of radiotherapy could predict the final response to treatment in oral squamous cell carcinoma (SCC). METHODS: Frozen sections from 31 cases of histologically confirmed oral SCC were stained with the monoclonal antibody Ki67 at diagnosis and after 10 Gy of radiotherapy. The percentage difference of Ki67 positive cells among the biopsy specimens taken at the beginning and after 10 Gy was correlated with the clinical response obtained at the end of the treatment and its significance determined. RESULTS: The percentage of Ki67 positive cells at diagnosis had no significant correlation with the final therapeutic result of radiotherapy. By contrast, the 32% difference of proliferating cells after 10 Gy of radiotherapy significantly differentiated responders from non-responders (p < 0.05). Furthermore, the abatement of the growth fraction after 10 Gy of radiotherapy was significantly correlated with the complete response (p < 0.01). CONCLUSIONS: These data show that the immunohistochemical evaluation of the abatement of Ki67 positive cells after 10 Gy of radiotherapy provides an independent variable of responsiveness to radiotherapy, allowing a reliable prediction of the final therapeutic result to be made.

Antigens, Neoplasm↗
PubMed1994

[Clinical nutrition in maxillofacial cancer surgery. A review of the literature].

The authors review the literature on problems of nutrition in patients with operable maxillofacial neoplasms. The causes of malnutrition in head-neck tumours will be particularly examined: metabolic alteration due to the presence of neoplasm; the tumour being situated in the first upper respiratory-digestive tracts; the side effects of chemotherapy and/or radiotherapy; the results of surgery and finally those of a late diagnosis. Once clinical nutrition has been indicated by both clinical and biochemical parameters, a plan for the most frequently used pre- postoperative treatments is drawn up. Reviewing the literature disagreement is found as the most effective method--enteral or parenteral--given that both solutions present advantages and disadvantages. The former is more physiological less expensive and simpler to carry out while the latter permits a more individualised form of treatment and the metabolic evaluation is simplified. The authors will go to present their own treatment plans: parenteral in the preoperative phase and in the postoperative patient a gradual weaning from parenteral to enteral treatment. The most important lines in both enteral and parenteral feeding are examined and the authors conclude by confirming that artificial nutritional therapy makes absolutely no difference to the prognosis but allows the patient to undergo the appropriate therapy.

Enteral Nutrition↗
PubMed1993

[Biopsy technics in oral oncology: excisional or incisional biopsy? A critical review of the literature and the authors' personal contribution].

The authors review the literature regarding bioptic techniques which are used in oral oncology, particularly referring to the dispute about incisional and excisional biopsy in cases of neoplastic or suspected lesions. As a matter of fact, though incisional biopsy at the oral cavity level is an easily executed technique, some clinicians found that an incision of a neoplasia could help its spreading or could help its spreading or could even increase its malignancy. Nevertheless, analyzing the literature, it can't be found, at present, the existence of data based on real clinical survey, which could prove a worse prognosis subsequent to a certain bioptic approach, even if some experimental studies on animal models, pointed out the potential danger caused by a neoplasia's incision. But, according to the authors, the oncological risk of metastasis' formation or of a local insemination is irrelevant if the operator follows the general rules of oncological surgery. To conclude, the authors present their diagnostic operative protocol, based on the principle that the diagnosis must always precede the treatment of the pathology. Therefore, when the size and site of the lesions allow it, incisional biopsy (simple or multiple) must always be chosen and, if necessary, must be preceded by the tolonium chloride stain.

Artifacts↗
PubMed1992

[Oral lichen planus and liver pathology. I. The prevalence of liver damage in a case load of 96 patients with oral lichen planus].

In order to evaluate if oral lichen planus (OLP) may be regarded as a marker of even unknown liver disease, 96 incident OLP cases were screened through anamnestic, laboratory, instrumental investigations and gastroenterology consultation. The frequency of hepatopathies was 23/96 (24%): 7 had cirrhosis, 3 had chronic active hepatitis, 2 had chronic persistent hepatitis, 10 steatosis and 1 had undetermined liver disease. Eleven of these 23 patients (48%) had unknown hepatopathies, although five of them had severe liver disorders (cirrhosis, chronic hepatitis). Forty-four of 73 patients without definite liver disorders (60%) had at least one abnormal liver parameter. This results confirm frequent association of OLP with hepatic damage and moreover it shown that OLP may be an important clinical sign of symptomless hepatopathies.

Adult↗
PubMed1992

[Oral lichen planus and liver pathology. II. The clinico-statistical correlations between oral manifestations and liver damage].

To characterize with more precision the association between oral lichen planus (OLP) and hepatopathies, 96 patients with OLP were separated in two groups ordered by presence or absence of liver diseases comparing some variables (age, sex, presence of pain, clinical variety, presence of skin lesions, alcohol consumption and exposure to drugs inducing hepatic injury) and evaluating the statistical significance. Factors associated with increased frequency of liver diseases were erosive variety of OLP (p = 0.024) and presence of pain (p = 0.026) (chi square test with Yates correction). It's confirmed that OLP patients with higher risk of liver disease are those that have erosive lesions with severe symptoms and often diffused in the entire oral cavity; furthermore, it's highlighted that the probability to find liver disease associated with reticular and plaque-like form of OLP is low, but not negligible.

Adult↗
PubMed1992

[Oral candidiasis as the first manifestation of HIV (human immunodeficiency virus) infection. An analysis of 2 cases].

The authors report two cases in which unexplained oral candidiasis led to the diagnosis of HIV infection with clinical form of AIDS-related complex (ARC). It is highlighted that the dentist showed investigate the causes of every unexplained oral candidiasis in adult because this opportunist infection may be the first sign of immunosuppression associated with AIDS and AIDS-related syndromes.

AIDS Serodiagnosis↗
PubMed1990

[Prevalence of cancer of the oral cavity and oropharynx].

A study was made to determine how prevalent oral and oropharyngeal cancer proved to be in 600 E.N.T. out-patients upon their initial examination. The aim was to ascertain which population was at high risk for thys type cancer through the use of computerized analysis of the risk factors. By scoring risk factors for oral and oropharyngeal cancer, subjects were classified into 3 risk classes: low, medium and high. Endoscopy proved positive in 22 cases only in the high risk class. Further diagnostic procedures, performed for all subjects, revealed 16 cases of squamous cell carcinoma, 1 'in situ' carcinoma, and 5 precancerous lesions of the oral cavity and oropharynx. This data is then discussed and the suggestion made that scoring such risk factors as tobacco and alcohol consumption could also be effective in identifying the high risk groups for this disease in a selective screening program.

Adult↗
PubMed1989

Appearance, site of occurrence, and physical and clinical characteristics of oral carcinoma in Torino, Italy.

The appearance, site of occurrence, and selected physical and clinical characteristics are reported for 102 symptomatic carcinomas diagnosed during a 30-month period in Torino, Italy. Erythroplasia was a more significant visual component than leukoplakia, confirming the results of a previous study on asymptomatic cancer in a US population. Floor of the mouth, oral tongue, and soft palate complex accounted for 75% of all sites and 84% of sites if posterior pillar is excluded. Seventeen percent of the lesions were T1, 60% T2, and 23% larger than T2. Size of the lesion was associated with anterior or posterior position and the mobility of the structure, as well as with ulceration, bleeding, and lymphadenopathy (55% of cancers had no nodal involvement). Tumefaction, burning, and pain were the most frequently reported symptoms. About 50% of patients experienced a time lapse between onset of symptoms and final diagnosis of less than 3 months, and this proportion was higher among patients with T1 cancers.

Adult↗
PubMed1989

[Keratotic lesions of the oral cavity. Notes on histopathologic differential diagnosis in leukoplakia, lichen planus, lupus erythematosus. Cases investigation].

A series of 24 white mouth lesions variously diagnosed as leukoplakia, lichen planus and discord lupus erythematosus is examined. A number of histological parameters were investigated using samples stained with haematoxylin-eosin and orcein and by Wohlgemulh's test. The 24 cases were also assessed by direct immunofluorescence (DIF) using the standard techniques. The aim of the study was to discover which of the histological and DIF findings were most helpful for diagnosis. The results confirm the view that histological diagnosis is only possible in some cases and that DIF helps to clarify histologically uncertain ones. Even so, clinical examination of the patient remains essential in order to eliminate the uncertainty created by the histological findings. It therefore follows that close collaboration between clinician and pathologist is essential.

Adult↗
PubMed1989

[Role of direct immunofluorescence in the diagnosis of oral lichen planus].

A series of 25 cases with clinical signs indicative of oral lichen planus was examined. Samples stained with haematoxylin-eosin as for traditional histology and others for DIF were taken in each case. The results obtained by both techniques were then compared with the clinical picture. It is concluded that DIF is a valuable diagnostic aid in doubtful cases.

Adult↗
PubMed1989

[Clinical and statistical study on the value of the sugar cube test in the measurement of the degree of radio-induced xerostomia].

Personal experience with the sugar cube test for evaluating the degree of xerostomy induced by radiation therapy carried out by means of 60Co photons on volumes including the parotid glands is reported. The execution technique is described and the processing of data deriving from a series of 480 tests carried out in 60 patients suffering from head-neck cancers reported. On the basis of experience it is maintained that the test presents the following advantages: simple execution, maximum tolerance, easy evaluation, possibility of numerically quantifying and graphically evidencing the course of xerostomy; in conclusion, it is considered that this can be advantageously adopted for both research and practical clinico-therapeutic purposes.

Adult↗
PubMed1986

Gastrointestinal cancer-associated antigen (GICA) in oral carcinoma.

Gastrointestinal cancer-associated antigen (GICA) is detected by means of a monoclonal antibody in the serum and pathologic tissues of patients with gastrointestinal tumors. This article compares serum and salivary GICA and carcinoembryonic antigen (CEA) levels in 19 healthy control subjects, 17 patients with benign oral cavity lesions, and 11 patients with squamous cell carcinoma of the oral cavity. Serum CEA levels were similar in all three groups, whereas salivary CEA levels were higher in patients with squamous cell carcinoma than in the control subjects (p less than 0.001) and the patients with benign lesions (p less than 0.025). Serum GICA levels gave the opposite result and were significantly lower in squamous cell cancer when compared with control subjects (p less than 0.0001) and patients with benign lesions (p less than 0.02). Values of GICA in saliva of patients with oral cancer were also lower than in the control subjects (p less than 0.02). The possible significance of this difference between the two antigens is discussed.

Adult↗