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Biomedical subjects

S G Thomas

Publications and source records attributed to S G Thomas.

46 records · Page 3Linked to original sources
PubMed1985

Exercise training and "ventilation threshold" in elderly.

Dynamic exercise training of the elderly increases maximal O2 uptake (VO2max); however, the effects of training on the ventilation threshold (VET) have not been studied. VET was identified as the final point before the ventilatory equivalent for O2 (VE/VO2) increased, without an increase in the ventilatory equivalent for CO2 (VE/VCO2). Inactive elderly males (mean age, 62 yr) were randomly assigned to a control (C, n = 44) or activity (A, n = 45) group. VO2max and VET were determined from an incremental treadmill test. Initial VO2max was not different between the C (2.34 +/- 0.42 l X min-1) and A (2.28 +/- 0.44 l X min-1) groups, nor was there a significant difference in the VO2 at the VET (C = 1.39 +/- 0.26 l X min-1; A = 1.31 +/- 0.23 l X min-1). The activity group trained for 30 min/day, 3 days/wk at an intensity of approximately 65-80% of VO2max. After 1 yr of training the activity group exhibited an 18% increase in VO2max (A = 2.70 +/- 0.54 l X min-1), but the change in VET was not significant (A = 1.39 +/- 0.28 l X min-1). There was no significant change in VO2max (C = 2.45 +/- 0.68 l X min-1) or VET (C = 1.38 +/- 0.31 l X min-1) in the control group. VET/VO2max declined significantly in the activity group (from 58 to 52% of VO2max). Change in VET/VO2max with training was not correlated with the initial VO2max value. We conclude that increases in aerobic capacity are more readily effected than alterations of the VET in elderly subjects.

Humans↗
PubMed1985

Determinants of the training response in elderly men.

As part of a prospective randomized trial of the effect of regular exercise in older men, factors determining the magnitude of VO2max increase observed with endurance training were examined in 88 elderly [age 62.9 +/- 3.0 (SD) yr] males. VO2max before and after training was recorded as the highest VO2 observed during two incremental treadmill tests. One year of thrice weekly training sessions increased VO2max (12%, P less than 0.05) in the training group relative to baseline and to a control group (n = 100). The association between the post-training VO2max (VO2max, T2) and the following explanatory variables was assessed using multiple regression analysis: the initial VO2max (VO2max, T1); the reason for stopping the initial treadmill test: leisure time activity during the year previous to the study: the training intensity (speed of walking or running, pulse rate during training, and percentage of heart rate reserve); pulmonary function (forced expiratory volume in 1 s); adiposity (skinfold thickness at 8 sites) and frequency of training. VO2max T1, speed of walking or running during training, reason for stopping the treadmill test, and skinfold thickness were significantly related to post-training VO2max. The intensity and frequency of the training stimulus explained over 10% of the variance in the training effect. Subjects whose test was halted because of fatigue increased VO2max more than those whose test was discontinued for medical or other reasons, even when speed of running was held constant. Previous activity had only a weak effect on training response. The total variance explained by these independent variables was 62%.

Aged↗
PubMedDate not supplied

A statistical view of FMRFamide neuropeptide diversity.

FMRFamide-like peptide (FLP) amino acid sequences have been collected and statistically analyzed. FLP amino acid composition as a function of position in the peptide is graphically presented for several major phyla. Results of total amino acid composition and frequencies of pairs of FLP amino acids have been computed and compared with corresponding values from the entire GenBank protein sequence database. The data for pairwise distributions of amino acids should help in future structure-function studies of FLPs. To aid in future peptide discovery, a computer program and search protocol was developed to identify FLPs from the GenBank protein database without the use of keywords.

Amino Acid Sequence↗
PubMedDate not supplied

A study to validate the Canadian Aerobic Fitness Test.

Our purpose was to assess the validity of VO2 max values predicted from The Canadian Aerobic Fitness Test (CAFT) by comparing them with peak VO2 values measured during a maximal treadmill protocol. Male and female subjects, 15-69 yr (n = 129), performed two submaximal exercise tests (CAFT protocol), and one maximal treadmill test. There was no significant heart rate habituation between the first two CAFT protocols. Peak VO2 values measured during the treadmill test (TM) were significantly higher than those predicted from the CAFT whether the sample was analyzed overall or categorized by sex. When the sample was categorized by age group, all but groups 1 (15-19) and 6 (60-69) had treadmill peak VO2 values significantly higher than those predicted using Jetté's equation. Using treadmill measured peak VO2 scores as the gold standard, VO2 max predictions using the CAFT protocol and Jetté equation placed individuals of lower fitness levels more accurately than highly fit individuals, into one of five fitness categories.

Adolescent↗